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The focus of the 2nd and 3rd year of our fellowship program is for our fellows to engage in hypothesis-driven research. Although 2 years can move quickly, the goal is to generate primary data to help support grant applications that will allow our fellows to develop into superb physician-scientists. While funding is provided for fellows throughout their 3 years of training, it is strongly encouraged to participate in the grant writing process early on to help facilitate future success.
By far, the message that we want to say is that the time of 2nd and 3rd Years is HIGHLY PROTECTED to make sure you can use those years to develop the foundation of your future career.
The first year fellows meet with the program director in the fall to discuss their research interests. After that meeting, MGH supports a vast array of potential research mentors that the fellows meet with to explore their research interests.
Mucosal Immunology and Biology Research Center- The major mission of the Mucosal Immunology and Developmental Gastroenterology Laboratories remains a multidisciplinary approach to characterize the role of the enterocyte in mucosal barrier function at the interface between microbial luminal stimuli and lymphoid effector responses.
Laboratory of Alessio Fasano, MD - We are currently investigating the composition and changes in the gastrointestinal microbiota to help determine why some individuals with an inherited predisposition to celiac disease develop clinical disease, while others do not. We are also working to uncover a biomarker and diagnostic tool for non-celiac gluten sensitivity. We are also investigating the role of the timing of gluten introduction to infants in the development of celiac disease, and working to uncover a biomarker and to develop a diagnostic tool for gluten sensitivity.
Laboratory of Maria Rosaria Fiorentino, PhD - The Fiorentino lab is interested in elucidating the molecular mechanisms of host-microbial interaction and understanding the impact of changes in the gut environment on brain function and behavior.
Laboratory of Bryan Hurley, PhD - Our overall research objective is to gain a better understanding of how injury, infection, and/or genetics drive mucosal inflammation and damage, manifesting as disease. More specifically, our team explores how bacterial pathogens and other noxious agents impact barrier integrity at the respiratory and digestive surface and elicit inflammatory processes.
Laboratory of Nitya Jain, PhD - The Jain Lab is dedicated to understanding how the immune system develops and operates in newborns, and in identifying the environmental host factors that dictate plasticity in neonatal immune function.
Laboratory of Marcia Kingsbury, PhD - A main focus of Marcy Kingsbury, PhD, Laboratory at Massachusetts General Hospital is how perinatal immune challenges and stressors impact neuroimmune function and gut-brain-immune interactions. We are particularly interested in how changes in immune cell function within the brain and gut early in development may give rise to cognitive and social behavior deficits and contribute to neurodevelopmental disorders such as autism spectrum disorder.
Laboratory of Hongmei Mou, PhD - The Mou Laboratory applies stem cell technologies to investigate personalized medicine approaches for lung and airway diseases including cystic fibrosis, asthma, bronchopulmonary dysplasia (BPD) and chronic obstructive pulmonary disorder (COPD).
Laboratory of Hai Ning Shi, DVM , PhD - Research in the Shi lab is focused on the effects of chronic intestinal helminth infection on concurrent infection with bacterial enteropathogens, the influence of early intestinal colonization with probiotic organisms on subsequent mucosal immune responses, and the effect of maternal gestational factors on the development of allergies in offspring.
Laboratory of Ali Zomorrodi, PhD - The Zomorrodi Lab strives to advance precision medicine through developing computational and systems biology approaches. The current focus of the lab is to construct computational mechanistic models of the microbiome and metabolism to better understand the pathogenesis of human diseases and to streamline the design of personalized treatments.
Pediatric Liver and Biliary Disease Center - The Pediatric Hepatobiliary & Pancreatic Program at MassGeneral Hospital for Children diagnoses and treats infants, children and adolescents with diverse hepatic, biliary and pancreatic disorders.
Pediatric Inflammatory Bowel Disease Center – The Pediatric IBD center at MGHfC studies the microbiome and genetic drivers of disease through a number of collaborations within Boston and beyond.
Adolescent and Pediatric Weight Center - The pediatric weight program at the Massachusetts General Hospital Weight Center provides comprehensive evaluation and care for children and adolescents who are overweight or obese.
Laboratory of Wayne Shreffler, MD PhD - The Shreffler Laboratory is interested in the mechanisms regulating both primary sensitization and the subsequent balance between immune progression or regulation that determines either clinical sensitivity or tolerance to mucosal allergens.
Laboratory of Allan Goldstein, MD - My laboratory is interested in the development of the enteric nervous system (ENS), a complex neuronal network whose principal function is to maintain normal intestinal motility.
Quality Improvement Research
Quality Improvement Research
In addition to their primary scholarly work, our Pediatric GI fellows are required to complete a longitudinal project in Quality Improvement.
Each pair of fellows per year work to develop a project during their first year in the program and carry out the project during their 2nd and 3rd years. With the mentoring of Dr. Kriston Ganguli (Medical Director of Ambulatory Quality and Safety at MGfC) and Dr. Esther Israel (Quality and Safety Chair at MGfC), fellows brainstorm on the idea and present it to the Division during their first year. They utilize multiple PDSA cycles during their 2nd and 3rd years and then complete the project during their 3rd year.
Fellows are expected to present their Quality Improvement Projects at MGHfC Research Day and have a publishable work product from their QI project by the end of fellowship.
Partners Clinical Process Improvement Leadership Program (CPIP)
Partners Clinical Process Improvement Leadership Program (CPIP)
The Mass General Brigham Clinical Process Improvement Leadership Program (CPIP) was launched across Mass General Brigham in 2010 with the purpose of engaging clinical teams in the use of process improvement tools to reduce variation in care and improve outcomes for patients. CPIP is a fast-paced, immersion program that gives participants from across the Mass General Brigham network the tools they need to evaluate and improve processes, within the span of four months.
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