Muscle relaxants

Acetazolamide, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with diuretics

Aliskiren/amlodipine/hydrochlorothiazide [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of EMA

Thiazides potentiate the action of skeletal muscle relaxants such as curare derivatives.

Aliskiren/hydrochlorothiazide [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of EMA

Thiazides, including hydrochlorothiazide, potentiate the action of skeletal muscle relaxants such as curare derivatives.

Alprazolam, muscle relaxants

Enhanced muscle relaxant effect

Amifampridine [1], depolarizing muscle relaxants ---> SmPC of [1] of EMA

The concomitant use of amifampridine and medicinal products with depolarising muscle relaxant effects may lead to a decreased effect of both products and should be taken into consideration.

Amifampridine [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of EMA

The concomitant use of amifampridine and medicinal products with non-depolarising muscle relaxant effects may lead to a decreased effect of both products and should be taken into consideration.

Amikacine [1], muscle relaxants ---> SmPC of [1] of eMC

The use of amikacin is not recommended in patients under the influence of anaesthetics or muscle-relaxing drugs as neuromuscular blockade and consequent respiratory depression may occur.

Aminoglycoside antibiotics, depolarizing muscle relaxants

Concurrent administration of aminoglycoside antibiotics with neuromuscular blockers may enhance the neuromuscular blockade

Aminoglycoside antibiotics, muscle relaxants

Concurrent administration of aminoglycoside antibiotics with neuromuscular blockers may enhance the neuromuscular blockade

Aminoglycoside antibiotics, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antibiotics

Amlodipine/valsartan/hydrochlorothiazide [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of EMA

Thiazides potentiate the action of curare derivatives.

Amphotericin, muscle relaxants

The hypokalaemia following amphotericin therapy may enhance the curariform actions of skeletal muscle relaxants.

Anaesthetics, muscle relaxants (non-depolarizing) ---> SmPC of [cisatracurium] of eMC

Anaesthetics increase the magnitude and/or duration of action of non-depolarising neuromuscular blocking agents

Antiarrhythmics, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antiarrhythmic medicinal products

Anticholinesterase, depolarizing muscle relaxants

The drug with anticholinesterase activity may prolong the neuromuscular blocking effects of depolarizing muscle relaxant

Anticholinesterase, muscle relaxants (non-depolarizing)

The drug with anticholinesterase activity may antagonize the neuromuscular blockade of non-depolarising drugs

Atenolol, peripheral muscle relaxants

Enhancement and prolongation of the muscle relaxant effect

Atenolol/nifedipine, peripheral muscle relaxants

Enhancement and prolongation of the muscle relaxant effect

Atracurium [1], depolarizing muscle relaxants ---> SmPC of [1] of eMC

A depolarising muscle relaxant should not be administered to prolong the neuromuscular blocking effects of non-depolarising blocking agents, as this may result in a prolonged and complex block

Atracurium [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

The combination of non-depolarising neuromuscular blocking agents with atracurium may produce a degree of neuromuscular blockade in excess of that which might be expected were an equipotent total dose of atracurium besilate administered.

Azathioprine [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

Azathioprine can reduce the blockade produced by non-depolarising agents such as tubocurarine.

Baclofen, muscle relaxants

The co-administration of baclofen with other muscle relaxants may cause mutual enhancement of effects

Bendroflumethiazide, muscle relaxants (non-depolarizing)

Thiazides may enhance and/or prolong the neuromuscular block of non-depolarizing muscle relaxants

Benzodiazepines, muscle relaxants ---> SmPC of [dipotassium clorazepate] of eMC

The co-administration may have an additive muscle relaxant effect

Betablockers, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with beta-blockers

Betablockers, peripheral muscle relaxants

The neuromuscular blockade by peripheral muscle relaxants may be potentiate by betablockers

Betaxolol, peripheral muscle relaxants

The co-administration may enhance or prolong the neuromuscular blocking effects

Botulinum toxin type A [1], muscle relaxants ---> SmPC of [1] of EMA

Theoretically, the effect of botulinum toxin may be potentiated by aminoglycoside antibiotics, spectinomycin, or other medicinal products that interfere with neuromuscular transmission (e.g. neuromuscular blocking medicinal products).

Botulinus toxin, muscle relaxants

Increased effects of the botulinus toxin

Botulinus toxin, muscle relaxants (non-depolarizing)

Increased effects of the botulinus toxin

Bromazepam, muscle relaxants

The co-administration of bromazepam with muscle relaxants may enhance the muscle-relaxant effect

Brotizolam, muscle relaxants

The co-administration of brotizolam and muscle relaxant drugs may enhance the muscle relaxant effect

Bumetanide, muscle relaxants (non-depolarizing)

A hypokaliemia can increase the sensitivity of the myocardium to nondepolarizing muscle relaxants

Bupivacaine, muscle relaxants (non-depolarizing)

Prolongation of the muscle relaxant effect

Calcium antagonists, muscle relaxants

The duration and intensity of action of muscle relaxants may be enhanced.

Calcium antagonists, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with calcium antagonists

Calcium gluconate, muscle relaxants (non-depolarizing)

The co-administration may cause arrythmias

Carbachol, depolarizing muscle relaxants

Carbachol may prolong the effect of depolarizing muscle relaxants

Carbachol, muscle relaxants (non-depolarizing)

Carbachol may decrease the effect of nondepolarizing muscle relaxants

Carbamazepine [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

Carbamazepine may antagonise the effects of non-depolarising muscle relaxants

Carvedilol [1], muscle relaxants ---> SmPC of [1] of eMC

Increased neuromuscular block.

Celiprolol, peripheral muscle relaxants

Increased neuromuscular blockade

Chlordiazepoxide, muscle relaxants

Increased effect of muscle relaxant

Chloroquine, muscle relaxants (non-depolarizing)

The co-administration may aggravate/unmask/induce a myasthenia or may increase the sensitivity to non-depolarising blocker

Chlorpromazine, muscle relaxants (non-depolarizing)

The co-administration may aggravate/unmask/induce a myasthenia or may increase the sensitivity to non-depolarising blocker

Chlortetracycline, muscle relaxants

Chlortetracycline increases the neuromuscular blockade

Cisatracurium [1], depolarizing muscle relaxants ---> SmPC of [1] of eMC

A depolarising muscle relaxant should not be administered to prolong the neuromuscular blocking effects of non-depolarising blocking agents, as this may result in a prolonged and complex block

Cisatracurium [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

Non-depolarising neuromuscular blocking agents increase the magnitude and/or duration of action of cisatracurium

Clindamycin [1], muscle relaxants ---> SmPC of [1] of eMC

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. It should be used with caution

Clindamycin, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antibiotics

Clobazam [1], muscle relaxants ---> SmPC of [1] of eMC

The co-administration may enhance the effect of the muscle relaxant

Cloprednol, muscle relaxants (non-depolarizing)

The combination can result in prolonged muscle relaxation and acute myopathy.

Codeine, muscle relaxants

The co-administration may cause additive depression of CNS and additive respiratory depression

Colistimethate [1], muscle relaxants ---> SmPC of [1] of EMA

Concomitant use of inhaled colistimethate sodium with neuromuscular blocking products should be undertaken with caution.

Colistin, muscle relaxants

Enhancement of the adverse effects

Corticosteroids, muscle relaxants (non-depolarizing) ---> SmPC of [deflazacort] of eMC

In patients treated with systemic corticosteroids, use of non-depolarising muscle relaxants can result in prolonged relaxation and acute myopathy.

Cyclophosphamide, depolarizing muscle relaxants

The co-administration may cause a long-lasting apnea

Dantrolene, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with dantrolene

Deflazacort [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

In patients treated with systemic corticosteroids, use of non-depolarising muscle relaxants can result in prolonged relaxation and acute myopathy.

Depolarizing muscle relaxants, distigmine

Distigmine may prolong the effect of depolarising muscle relaxant and should not be combined

Depolarizing muscle relaxants, edrophonium [2] ---> SmPC of [2] of eMC

Edrophonium should not be used in conjunction with depolarising muscle relaxants such as suxamethonium as neuromuscular blockade may be potentiated and prolonged apnoea may result.

Depolarizing muscle relaxants, esketamine

Prolonged duration of myorelaxant effect

Depolarizing muscle relaxants, galantamine [2] ---> SmPC of [2] of eMC

Galantamine, as a cholinomimetic, is likely to exaggerate succinylcholine-type muscle relaxation during anaesthesia, especially in cases of pseudocholinesterase deficiency.

Depolarizing muscle relaxants, isoflurane [2] ---> SmPC of [2] of eMC

Muscle relaxants are markedly potentiated by isoflurane.

Depolarizing muscle relaxants, mivacurium [2] ---> SmPC of [2] of eMC

A depolarising muscle relaxant should not be administered to prolong the neuromuscular blocking effects of non-depolarising blocking agents, as this may result in a prolonged and complex block

Depolarizing muscle relaxants, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

A depolarising muscle relaxant should not be administered to prolong the neuromuscular blocking effects of non-depolarising blocking agents, as this may result in a prolonged and complex block

Depolarizing muscle relaxants, neostigmine

The co-administration (contraindicated) may potentiate the effect of depolarising muscle relaxant

Depolarizing muscle relaxants, parasympathomimetics

The co-administration may prolong the muscle relaxant effect

Depolarizing muscle relaxants, pyridostigmine

Pyridostigmine may prolong the effect of depolarising muscle relaxants (e.g. suxamethonium).

Depolarizing muscle relaxants, rivastigmine [2] ---> SmPC of [2] of EMA

As a cholinesterase inhibitor, rivastigmine may exaggerate the effects of succinylcholine-type muscle relaxants during anaesthesia.

Desflurane, muscle relaxants

Commonly used muscle relaxants are potentiated by desflurane.

Diamorphine, muscle relaxants

Diamorphine may enhance the effect of muscle relaxants

Diazepam, muscle relaxants

Possible pharmacodynamic antagonism. Modified intensity of neuromuscular blockage. Special caution is recommended.

Digitoxin, peripheral muscle relaxants

The co-administration may increase the digitoxin effect and promote heart rhythm disorders

Dihydrocodeine, muscle relaxants

The co-administration may cause additive depression of CNS and additive respiratory depression

Dipotassium clorazepate, muscle relaxants

The co-administration may have an additive muscle relaxant effect

Diuretics, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with diuretics

Donepezil [1], muscle relaxants ---> SmPC of [1] of eMC

There is the potential for synergistic activity of donepezil with concomitant treatment involving medications such as other neuro-muscular blocking agents

Enflurane, muscle relaxants (non-depolarizing)

The co-administration may enhance and/or prolong the neuromuscular block

Esketamine, muscle relaxants (non-depolarizing)

Prolonged duration of myorelaxant effect

Ethyl loflazepate, muscle relaxants

The co-administration may cause a mutual potentiation of the depressor effect on the CNS

Fentanyl [1], muscle relaxants ---> SmPC of [1] of EMA

The concomitant use of fentanyl with other central nervous system depressants may produce additive depressant effects.

Fludrocortisone, muscle relaxants (non-depolarizing)

Corticosteroids may decrease or enhance the neuromuscular blocking action.

Flunitrazepam, muscle relaxants

The co-administration may enhance the muscle relaxant effect

Fluocortolone, muscle relaxants (non-depolarizing)

The combination can result in prolonged muscle relaxation and acute myopathy.

Fluphenazine [1], muscle relaxants ---> SmPC of [1] of eMC

Phenothiazines may enhance the absorption of neuromuscular blocking agents.

Flupirtine, muscle relaxants

Flupirtine may potentiate the effect of skeletal muscle relaxant drugs.

Flurazepam, muscle relaxants

Enhancement of the muscle relaxant effect

Furosemide, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with diuretics

Gallopamil, muscle relaxants

Enhanced muscle relaxant effect

Ganglionic blockers, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with ganglion blocking agents

Gentamicin, muscle relaxants

Concurrent administration of gentamicin with neuromuscular blockers may enhance the neuromuscular blockade

Glucocorticoids, muscle relaxants (non-depolarizing)

The combination can cause prolonged muscle relaxation and acute myopathy.

Guaifenesin, muscle relaxants

Increased effect of muscle relaxant

Halothane, muscle relaxants (non-depolarizing)

The co-administration may enhance and/or prolong the neuromuscular block

Hexametonium, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with ganglion blocking agents

Histamine dihydrochloride [1], muscle relaxants ---> SmPC of [1] of EMA

It has been noted that neuromuscular blocking agents, narcotic analgesics, and various contrast media can induce the release of endogenous histamine; therefore the additive effect should be considered

Hydantoins, muscle relaxants (non-depolarizing)

Decreased muscle relaxant effect after chronic administration of phenytoin

Hydralazine [1], muscle relaxants ---> SmPC of [1] of eMC

Concurrent treatment of hydralazine with other antihypertensives may potentate the effects

Hydrochlorothiazide, muscle relaxants (non-depolarizing) ---> SmPC of [aliskiren/hydrochlorothiazide] of EMA

Thiazides potentiate the action of curare derivatives.

Hydrocortisone, muscle relaxants (non-depolarizing)

The combination can result in prolonged muscle relaxation

Hydromorphone, muscle relaxants

Increased effect of muscle relaxant and of respiratory depression

Hydroxyzine [1], muscle relaxants ---> SmPC of [1] of eMC

Patients should be warned that hydroxyzine may enhance their response to skeletal muscle relaxants

Irinotecan [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

Since irinotecan has anticholinesterase activity, drugs with anticholinesterase activity may prolong the neuromuscular blocking effects of suxamethonium and the neuromuscular blockade of non-depolarising drugs may be antagonised.

Isoflurane [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

Muscle relaxants are markedly potentiated by isoflurane.

Ketamine [1], muscle relaxants ---> SmPC of [1] of eMC

The use of ketamine with other central nervous system (CNS) depressants can potentiate CNS depression and/or increase risk of developing respiratory depression.

Ketamine, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with ketamine

Labetalol, muscle relaxants (non-depolarizing)

The co-administration may enhance and/or prolong the neuromuscular block of non-depolarising blocker

Lidocaine [1], muscle relaxants ---> SmPC of [1] of eMC

There may be an increased risk of enhanced and prolonged neuromuscular blockade in patients treated concurrently with muscle relaxants (e.g. suxamethonium)

Lignocaine, muscle relaxants (non-depolarizing)

The co-administration may enhance and/or prolong the neuromuscular block

Lincomycin, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antibiotics

Lisinopril/hydrochlorothiazide [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

The effect of non-depolarising muscle relaxants may be potentiated by hydrochlorothiazide.

Lithium carbonate, muscle relaxants

The co-administration may enhance and/or prolong the neuromuscular block

Lithium, muscle relaxants

The co-administration may enhance and/or prolong the neuromuscular block

Lithium, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with lithium salts

Loprazolam [1], muscle relaxants ---> SmPC of [1] of eMC

Additive synergy has been observed with neuromuscular depressants (curare-like drugs and muscle relaxants).

Lorazepam, muscle relaxants

The co-administration of lorazepam with muscle relaxants may enhance the muscle-relaxant effect

Lormetazepam, muscle relaxants

The co-administration of lormetazepam with muscle relaxants may enhance the muscle-relaxant effect

Losartan/hydrochlorothiazide [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

Possible increased responsiveness to the muscle relaxant.

Lymecycline, muscle relaxants (non-depolarizing)

The co-administration may enhance and/or prolong the neuromuscular block

Magnesium sulfate, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with magnesium sulfate

Magnesium, muscle relaxants (non-depolarizing) ---> SmPC of [cisatracurium] of eMC

Magnesium salts increase the magnitude and/or duration of action of non-depolarising neuromuscular blocking agents

Mannitol, muscle relaxants (non-depolarizing) ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with diuretics

Medazepam, muscle relaxants

The effect of muscle relaxants may be enhanced

Mepivacaine, muscle relaxants (non-depolarizing)

Mepivacaine prolongs the effect of the non-depolarizing muscle relaxant

Methylprednisolone [1], muscle relaxants (non-depolarizing) ---> SmPC of [1] of eMC

Antagonism of the neuromuscular blocking effects of pancuronium and vecuronium has been reported in patients taking corticosteroids.

Metoclopramide, muscle relaxants

Metoclopramide may prolong the effect of muscle relaxants

Metolazone, muscle relaxants (non-depolarizing)

The co-administration may enhance and/or prolong the neuromuscular block

Metoprolol, peripheral muscle relaxants

The neuromuscular blockade by peripheral muscle relaxants may be potentiate by betablockers

Midazolam [1], muscle relaxants ---> SmPC of [1] of EMA

Midazolam may cause potentiation of muscle relaxants, with increased CNS depressant effects.

Mivacurium, muscle relaxants (non-depolarizing) [2] ---> SmPC of [2] of eMC

The combination of non-depolarising neuromuscular blocking agents with mivacurium may produce a degree of neuromuscular blockade in excess of that which might be expected were an equipotent total dose of mivacurium besilate administered.

Muscle relaxants (non-depolarizing) [1], protamine ---> SmPC of [1] of eMC

Protamine sulphate may increase the magnitude and/or duration of action of non-depolarising neuromuscular blocking agents.

Muscle relaxants (non-depolarizing), muscle relaxants (non-depolarizing)

The co-administration may have a synergistic effect

Muscle relaxants (non-depolarizing), neomycin ---> SmPC of [atracurium] of eMC

The effect of non-depolarising muscle relaxants may be enhanced by aminoglycosides.

Muscle relaxants (non-depolarizing), neostigmine

Neostigmine antagonizes the neuromuscular blockade of nondepolarizing muscle relaxant

Muscle relaxants (non-depolarizing), pancuronium [2] ---> SmPC of [2] of eMC

Enhancement of pancuronium effect

Muscle relaxants (non-depolarizing), penicillamine

The co-administration may aggravate/unmask/induce a myasthenia or may increase the sensitivity to non-depolarising blocker

Muscle relaxants (non-depolarizing), phenytoin ---> SmPC of [cisatracurium] of eMC

Decreased muscle relaxant effect after chronic administration of phenytoin

Muscle relaxants (non-depolarizing), piperacillin

It is expected that the neuromuscular blockade produced by any of the non-depolarising muscle relaxants could be prolonged in the presence of piperacillin.

Muscle relaxants (non-depolarizing), piperacillin/tazobactam [2] ---> SmPC of [2] of eMC

It is expected that the neuromuscular blockade produced by any of the non-depolarising muscle relaxants could be prolonged in the presence of piperacillin.

Muscle relaxants (non-depolarizing), polymyxin ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antibiotics

Muscle relaxants (non-depolarizing), prednisolone

Prednisolone may prolong the muscle relaxant effect of nondepolarizing muscle relaxants

Muscle relaxants (non-depolarizing), prednisone [2] ---> SmPC of [2] of eMC

Muscle relaxation may be prolonged.

Muscle relaxants (non-depolarizing), procainamide ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antiarrhythmic medicinal products

Muscle relaxants (non-depolarizing), procaine

Effect prolongation of procain

Muscle relaxants (non-depolarizing), propranolol ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with beta-blockers

Muscle relaxants (non-depolarizing), pyridostigmine [2] ---> SmPC of [2] of eMC

Pyridostigmine antagonises the effect of non-depolarising muscle relaxants (e.g. pancuronium and vecuronium).

Muscle relaxants (non-depolarizing), quinidine ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antiarrhythmic medicinal products

Muscle relaxants (non-depolarizing), rocuronium [2] ---> SmPC of [2] of eMC

Administration of other non-depolarising neuromuscular blocking agents in combination with rocuronium may produce attenuation or potentiation of the neuromuscular

Muscle relaxants (non-depolarizing), sevoflurane [2] ---> SmPC of [2] of eMC

As with other inhalational anaesthetic agents, sevoflurane affects both the intensity and duration of neuromuscular blockade by non-depolarising muscle relaxants.

Muscle relaxants (non-depolarizing), sotalol [2] ---> SmPC of [2] of eMC

The neuromuscular blockade is prolonged by beta-blocking agents.

Muscle relaxants (non-depolarizing), spectinomycin ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antibiotics

Muscle relaxants (non-depolarizing), steroids

The co-administration may aggravate/unmask/induce a myasthenia or may increase the sensitivity to non-depolarising blocker

Muscle relaxants (non-depolarizing), succinylcholine ---> SmPC of [atracurium] of eMC

A depolarising muscle relaxant should not be administered to prolong the neuromuscular blocking effects of non-depolarising blocking agents, as this may result in a prolonged and complex block

Muscle relaxants (non-depolarizing), suxamethonium ---> SmPC of [atracurium] of eMC

A depolarising muscle relaxant should not be administered to prolong the neuromuscular blocking effects of non-depolarising blocking agents, as this may result in a prolonged and complex block

Muscle relaxants (non-depolarizing), telmisartan/hydrochlorothiazide [2] ---> SmPC of [2] of EMA

The effect of nondepolarizing skeletal muscle relaxants may be potentiated by hydrochlorothiazide.

Muscle relaxants (non-depolarizing), tetracyclines ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antibiotics

Muscle relaxants (non-depolarizing), thiazides ---> SmPC of [aliskiren/hydrochlorothiazide] of EMA

Thiazides potentiate the action of curare derivatives.

Muscle relaxants (non-depolarizing), triamcinolone acetonide

Corticosteroids may decrease or enhance the neuromuscular blocking action.

Muscle relaxants (non-depolarizing), triamcinolone [2] ---> SmPC of [2] of eMC

Corticosteroids may decrease or enhance the neuromuscular blocking action.

Muscle relaxants (non-depolarizing), trimetaphan ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with ganglion blocking agents

Muscle relaxants (non-depolarizing), vancomycin ---> SmPC of [atracurium] of eMC

As with all non-depolarising neuromuscular blocking agents the magnitude and/or duration of a non-depolarising neuromuscular block may be increased as a result of interaction with antibiotics

Muscle relaxants (non-depolarizing), vecuronium [2] ---> SmPC of [2] of eMC

Administration of other non-depolarising neuromuscular blocking agents in combination with vecuronium may produce attenuation or potentiation of the neuromuscular

Muscle relaxants, netilmicin

Possible increase of neuromuscular blockade

Muscle relaxants, nicomorphine

The co-administration may enhance the muscle relaxant effect

Muscle relaxants, nicotinic acid

Nicotinic acid may potentiate the blood-pressure lowering effect

Muscle relaxants, nitrazepam

The co-administration of nitrazepam with muscle relaxants may potentiate the muscle relaxant effect

Muscle relaxants, opioid analgesics

Increased effect of muscle relaxant and of respiratory depression

Muscle relaxants, oxazepam

The co-administration of oxazepam and muscle relaxants may enhance the muscle relaxant effect

Muscle relaxants, oxycodone [2] ---> SmPC of [2] of eMC

Central nervous system depressants can enhance the adverse reactions of oxycodone, in particular respiratory depression.

Muscle relaxants, paromomycin

The aminoglycoside antibiotic may enhance the effect of muscle relaxant agent

Muscle relaxants, phenothiazines ---> SmPC of [fluphenazine] of eMC

Phenothiazines may enhance the absorption of neuromuscular blocking agents.

Muscle relaxants, phenylalkylamines

Enhanced muscle relaxant effect

Muscle relaxants, prazepam

Enhancement of neuromuscular blockade.

Muscle relaxants, pregnancy

Should be used during pregnancy only if the potential benefit to the mother outweighs any potential risk to the foetus.

Muscle relaxants, propafenone

Enhancement of muscle relaxant effect

Muscle relaxants, quinine

Increased effect of muscle relaxant

Muscle relaxants, temazepam

The co-administration of temazepam and muscle relaxants may enhance the muscle relaxant effect

Muscle relaxants, tetrazepam

The co-administration may enhance the muscle relaxant effect

Muscle relaxants, tizanidine

The combination of tizanidine with other muscle relaxants may cause mutual enhancement of effect

Muscle relaxants, tobramycin

The aminoglycoside antibiotic may enhance the effect of muscle relaxant agent

Muscle relaxants, trandolapril/verapamil [2] ---> SmPC of [2] of eMC

The effect of muscle relaxants (such as neuromuscular blockers) may be enhanced.

Muscle relaxants, trazodone [2] ---> SmPC of [2] of eMC

Trazodone may enhance the effects of muscle relaxants, and caution should be exercised in such instances.

Muscle relaxants, triazolam

The co-administration of triazolam and muscle relaxants may enhance the muscle relaxant effect

Muscle relaxants, vancomycin [2] ---> SmPC of [2] of eMC

There is an increased potential of neuromuscular blockade with concomitant administration of vancomycin and neuromuscular blocking agents.

Muscle relaxants, verapamil [2] ---> SmPC of [2] of eMC

The effects of neuromuscular blocking agents employed in anaesthesia may be potentiated.

Muscle relaxants, zolpidem

The co-administration of zolpidem with muscle relaxants may potentiate the muscle-relaxant effect

Muscle relaxants, zopiclone

The co-administration may enhance the muscle-relaxant effect

Muscle relaxants, zuclopenthixol [2] ---> SmPC of [2] of eMC

Zuclopenthixol may prolong the action of neuromuscular blocking agents.

Oxprenolol, peripheral muscle relaxants

The neuromuscular blockade by peripheral muscle relaxants may be potentiate by betablockers

Peripheral muscle relaxants, pindolol

The neuromuscular blockade by peripheral muscle relaxants may be potentiate by betablockers

Peripheral muscle relaxants, propranolol

Enhancement of neuromuscular blockade

Peripheral muscle relaxants, talinolol

The neuromuscular blockade by peripheral muscle relaxants may be potentiate by betablockers