Xipamide
Ability to drive, xipamide [2] ---> SmPC of [2] of eMC
None known.
ACE inhibitors, xipamide
Risk of significant decrease of blood pressure and/or acute renal failure, particularly in patients with hyponatremia
Acetylsalicylic acid, xipamide
Possible decrease of the antihypertensive and diuretic effect of xipamide
ACTH, xipamide [2] ---> SmPC of [2] of eMC
Concomitant use with xipamide may provoke hypokalaemia.
Adrenaline, xipamide
The co-administration may weaken the adrenaline effect
Alcohol, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Alfa-adrenergic receptor blockers, xipamide
Increased hypotensive effect. Risk of orthostatic hypotension
Alfuzosin, xipamide
Increased hypotensive effect. Risk of orthostatic hypotension
Amiloride, xipamide
The co-administration may cause hypokaliemia or hyperkaliemia
Aminoglycoside antibiotics, xipamide
Increased risk of ototoxicity and nephrotoxicity
Amiodarone, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Amisulpride, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Amphotericin, xipamide [2] ---> SmPC of [2] of eMC
Concomitant use with xipamide may provoke hypokalaemia.
Antidiabetics, xipamide [2] ---> SmPC of [2] of eMC
Diabetic patients may require an increase in their dose of insulin or oral hypoglycaemic drug.
Antigout preparations, xipamide
The co-administration may weaken the uric acid lowering effect
Antihypertensives, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Baclofen, xipamide
The co-administration may potentiate the hypotensive effect
Barbiturates, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Benzamides, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Bepridil, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Betablockers, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Breast-feeding, xipamide [2] ---> SmPC of [2] of eMC
No information is available on the excretion of xipamide in breast milk. Treatment should be avoided in breast feeding mothers.
Butyrophenones, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Calcium, xipamide
Risk of hypercalcemia due to decreased calcium elimination
Carbamazepine, xipamide
Risk of symptomatic hyponatremia
Carbenoxolone, xipamide [2] ---> SmPC of [2] of eMC
Concomitant use with xipamide may provoke hypokalaemia.
Chlorpromazine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Cholestyramine, xipamide
Decreased absorption of xipamide
Cisapride, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Class IA antiarrhythmic agents, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Class III antiarrhythmic agents, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Colestipol, xipamide
Decreased absorption of xipamide
Corticosteroids, xipamide
Increased risk of hypokaliemia (additive effect). Decreased hypotensive effect (water and sodium retention by corticosteroid)
Coxibs, xipamide
Possible decrease of the antihypertensive and diuretic effect of xipamide
Curare-type muscle relaxants, xipamide
Decreased elimination of curare-type muscle relaxant with potentiation or prolongation of its effect
Cyamemazine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Cyclophosphamide, xipamide
Risk of enhanced bone marrow toxicity
Cyclosporine, xipamide
Risk of increased creatinine plasma levels without modification of circulating cyclosporine levels, even with normal water and sodium balance
Cytostatics, xipamide
Risk of enhanced bone marrow toxicity
Digital glycosides, xipamide [2] ---> SmPC of [2] of eMC
The dosage of cardiac glycosides may require adjustment when used in conjunction with xipamide
Diphemanil, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Disopyramide, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Diuretics, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Dofetilide, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Doxazosin, xipamide
Increased hypotensive effect. Risk of orthostatic hypotension
Droperidol, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Erythromycin, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Fluorouracil, xipamide
Risk of enhanced bone marrow toxicity
Fosphenytoin, xipamide
Decreased diuretic effect
Furosemide, xipamide
Increased risk of hypokaliemia (additive effect)
Halofantrine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Haloperidol, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Hydroquinidine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Hypokalemia, xipamide [2] ---> SmPC of [2] of eMC
Concomitant use with xipamide may provoke hypokalaemia.
Ibutilide, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Imipramine, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Indapamide [1], xipamide ---> SmPC of [1] of eMC
The co-administration of indapamide with diuretics which may cause hypokalaemia is not recommended.
Indometacin, xipamide
Possible decrease of the antihypertensive and diuretic effect of xipamide
Insulin, xipamide [2] ---> SmPC of [2] of eMC
Diabetic patients may require an increase in their dose of insulin or oral hypoglycaemic drug.
Iodinated contrast media, xipamide [2] ---> SmPC of [2] of eMC
In case of diuretic-induced dehydration, there is an increased risk of acute renal failure, especially with high doses of the iodine product.
Kaliuretic medicines, xipamide [2] ---> SmPC of [2] of eMC
Concomitant use with xipamide may provoke hypokalaemia.
Ketanserin, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Levomepromazine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Lithium, xipamide [2] ---> SmPC of [2] of eMC
Increased serum lithium levels may occur due to diminished urinary excretion.
Loop diuretics, xipamide
The co-administration increases the risk of fluid and electrolyte imbalance disorders
Metformin, xipamide
Increased risk of metformin-induced lactate acidosis due to the possibility of functional renal failure associated with a diuretic treatment
Methotrexate, xipamide
Risk of enhanced bone marrow toxicity
Mineralocorticoids, xipamide
Increased risk of hypokaliemia (additive effect). Decreased hypotensive effect (water and sodium retention by corticosteroid)
Mizolastine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Moxifloxacin, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Neuroleptics, xipamide
Hypotensive effect and increased risk of orthostatic hypotension (additive effect)
Noradrenaline, xipamide
The co-administration may weaken the noradrenaline effect
NSAID, xipamide
Possible decrease of the antihypertensive and diuretic effect of xipamide
Organic nitrates, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Penicillin G, xipamide [2] ---> SmPC of [2] of eMC
Concomitant use with xipamide may provoke hypokalaemia.
Pentamidine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Phenothiazines, xipamide [2] ---> SmPC of [2] of eMC
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Phenytoin, xipamide
Decreased diuretic effect
Platinum compound, xipamide
Risk of additive ototoxic and nephrotoxic effects
Potassium-sparing diuretics, xipamide
The co-administration may cause hypokaliemia or hyperkaliemia
Pregnancy, xipamide [2] ---> SmPC of [2] of eMC
Care should be taken when treating hypertension or oedema in pregnancy as excessive use may result in hypovolaemia and reduced placental perfusion. As with all drugs, treatment should be avoided in the first trimester of pregnancy.
Quinidine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Salicylates, xipamide
Possible decrease of the antihypertensive and diuretic effect of xipamide
Sotalol, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Sparfloxacin, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Spironolactone, xipamide
The co-administration may cause hypokaliemia or hyperkaliemia
Stimulant laxatives, xipamide [2] ---> SmPC of [2] of eMC
Concomitant use with xipamide may provoke hypokalaemia.
Sulpiride, xipamide [2] ---> SmPC of [2] of eMC
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Sultopride, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Tacrolimus, xipamide
Risk of increased creatinine plasma levels without modification of circulating cyclosporine levels, even with normal water and sodium balance
Tamsulosin, xipamide
Increased hypotensive effect. Risk of orthostatic hypotension
Terazosine, xipamide
Increased hypotensive effect. Risk of orthostatic hypotension
Terfenadine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Tetracosactide, xipamide
Increased risk of hypokaliemia (additive effect). Decreased hypotensive effect (water and sodium retention by corticosteroid)
Thiazides, xipamide
The co-administration increases the risk of fluid and electrolyte imbalance disorders
Thioridazine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Tiapride, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Torsades de pointes inducing drugs, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Triamterene, xipamide
The co-administration may cause hypokaliemia or hyperkaliemia
Tricyclic antidepressant, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Trifluoperazine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
Vasodilators, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Vincamine, xipamide
The combination increases the risk of ventricular arrhythmias, particularly torsades de pointes (favored by hypokaliemia). It is recommended a special caution
CONTRAINDICATIONS of Xipamide
Xipamide is contra-indicated in
- severe electrolyte deficiency,
- precomatose states associated with liver cirrhosis,
- severe renal insufficiency,
- hypersensitivity to xipamide and
- untreated Addison's disease.
http://www.medicines.org.uk/emc/
Xylometazoline
Ability to drive, xylometazoline [2] ---> SmPC of [2] of eMC
None.
Adrenergic bronchodilators, xylometazoline
Xylometazoline should not be used, when the patient is treated with adrenergic bronchodilators
Breast-feeding, xylometazoline [2] ---> SmPC of [2] of eMC
Caution should be exercised and xylometazoline should be used only on prescription whilst breastfeeding.
Hypertensive drugs, xylometazoline
As for all sympathomimetics, a reinforcement of the systemic effects of xylometazoline by concomitant use of hypertensive drugs cannot be excluded
IMAOs, xylometazoline [2] ---> SmPC of [2] of eMC
As for all sympathomimetics, a reinforcement of the systemic effects of xylometazoline by concomitant use of monoamine oxidase inhibitors cannot be excluded, especially in case of overdose.
Phenothiazines, xylometazoline
Xylometazoline should not be used, when the patient is treated with phenothiazines
Pregnancy, xylometazoline [2] ---> SmPC of [2] of eMC
It is advisable to take the precaution of not using xylometazoline during pregnancy.
Sibutramine [1], xylometazoline ---> SmPC of [1] of eMC
Concomitant use of Sibutramine with other drugs which may raise the blood pressure or heart rate has not been systematically evaluated. Caution should be used when prescribing sibutramine to patients who use these medicines.
Tetracyclic antidepressant, xylometazoline [2] ---> SmPC of [2] of eMC
As for all sympathomimetics, a reinforcement of the systemic effects of xylometazoline by concomitant use of tetracyclic antidepressants cannot be excluded, especially in case of overdose.
Tricyclic antidepressant, xylometazoline [2] ---> SmPC of [2] of eMC
As for all sympathomimetics, a reinforcement of the systemic effects of xylometazoline by concomitant use of tricyclic antidepressants cannot be excluded, especially in case of overdose.
CONTRAINDICATIONS of Xylometazoline
- Known hypersensitivity to xylometazoline.
- Patients with transĀ-sphenoidal hypophysectomy or surgery exposing the dura mater.
http://www.medicines.org.uk/emc/