Hypotensors
Hypotensors
Ability to drive, antihypertensives
It should be taken into account that occasionally dizziness or asthenia may occur during treatment with hypotensive medicinal products
ACE inhibitors, antihypertensives
The co-administration may enhance the hypotensive effect
Acebutolol, antihypertensives
Concomitant administration may increase the blood pressure lowering effect of beta-blockers.
Aceclofenac [1], antihypertensives ---> SmPC of [1] of eMC
NSAID's may reduce the effect of antihypertensives.
Acetazolamide, antihypertensives
Acetazolamide can enhance the effect of the antihypertensive agent
Acetylsalicylic acid, antihypertensives ---> SmPC of [parecoxib] of EMA
NSAIDs may reduce the effect of antihypertensive medicinal products.
AIIRA, antihypertensives
Additive hypotensive effect
Alcohol, antihypertensives ---> SmPC of [lercanidipine] of eMC
Alcohol should be avoided since it may potentiate the effect of vasodilating antihypertensive drugs.
Aldesleukin [1], antihypertensives ---> SmPC of [1] of eMC
The co-administration may enhance the hypotension caused by aldesleukin.
Alfuzosin [1], antihypertensives ---> SmPC of [1] of eMC
The concomitant use can cause profound hypotension.
Alimemazine [1], antihypertensives ---> SmPC of [1] of eMC
The co-administration may increase the hypotensive effect
Aliskiren/amlodipine [1], antihypertensives ---> SmPC of [1] of EMA
The blood pressure lowering effects of amlodipine adds to the blood pressure-lowering effects of other antihypertensive medicinal products.
Aliskiren/amlodipine/hydrochlorothiazide [1], antihypertensives ---> SmPC of [1] of EMA
The blood pressure lowering effects of amlodipine add to the blood pressure lowering effects of other antihypertensive medicinal products.
Aliskiren/hydrochlorothiazide [1], antihypertensives ---> SmPC of [1] of EMA
The antihypertensive effect of aliskiren/hydrochlorothiazide may be increased with the concomitant use of other antihypertensive agents.
Alizapride, antihypertensives
The coadministration enhances the hypotensive effect and increases the risk of orthostatic hypotension
Alprostadil [1], antihypertensives ---> SmPC of [1] of eMC
Alprostadil may enhance the effects of antihypertensives
Amfepramone, antihypertensives
Weakening of the hypotensive effect
Amifostine, antihypertensives ---> SmPC of [telmisartan] of EMA
Based on its pharmacological properties it can be expected that amifostine may potentiate the hypotensive effects of all antihypertensives
Amiloride, antihypertensives
Increased hypotensive effect
Amiloride/hydrochlorothiazide, antihypertensives
The hypotensive effect of amiloride/hydrochlorothiazide can be enhanced by other hypotensive agents
Amisulpride [1], antihypertensives ---> SmPC of [1] of eMC
Caution is advised when coadministering amisulpride with antihypertensive drugs and other hypotensive medications
Amitriptyline [1], antihypertensives ---> SmPC of [1] of eMC
In general, the hypotensive effect is enhanced, but the effect of adrenergic neurone blockers (eg guanethidine) and clonidine may be antagonized.
Amlodipine, antihypertensives ---> SmPC of [aliskiren/amlodipine] of EMA
The blood pressure lowering effects of amlodipine adds to the blood pressure-lowering effects of other antihypertensive medicinal products.
Amlodipine/valsartan [1], antihypertensives ---> SmPC of [1] of EMA
The blood pressure lowering effect can be increased by concomitant use
Amlodipine/valsartan/hydrochlorothiazide [1], antihypertensives ---> SmPC of [1] of EMA
Dafiro HCT may increase the hypotensive effect of other antihypertensive agents.
Amphetamine, antihypertensives
Amfetamines may decrease the effectiveness of antihypertensive medications.
Antidepressants, antihypertensives
Orthostatic hypotension may be aggravated
Antihypertensives [1], bromocriptine ---> SmPC of [1] of eMC
Caution is required in patients who are on concomitant therapy with, or have recently been treated with drugs that can alter blood pressure.
Antihypertensives [1], celiprolol ---> SmPC of [1] of eMC
Concomitant use may potentiate the orthostatic hypotensive effects of beta blockers.
Antihypertensives [1], codeine ---> SmPC of [1] of eMC
Enhanced hypotensive effect.
Antihypertensives [1], diazepam ---> SmPC of [1] of eMC
Enhanced hypotensive effect
Antihypertensives [1], oxazepam ---> SmPC of [1] of eMC
Antihypertensives enhance hypotensive effects.
Antihypertensives [1], phenelzine ---> SmPC of [1] of eMC
Phenelzine may potentiate the action of antihypertensives
Antihypertensives [1], phentolamine ---> SmPC of [1] of eMC
Phentolamine may augment the hypotensive effect of other antihypertensive agents.
Antihypertensives [1], procarbazine ---> SmPC of [1] of eMC
Procarbazine may enhance the effect of anti-hypertensive agents
Antihypertensives [1], vasodilators ---> SmPC of [1] of eMC
Diuretics potentiate the action of antihypertensive drugs
Antihypertensives, antihypertensives
Additive hypotensive effect
Antihypertensives, apomorphine [2] ---> SmPC of [2] of eMC
Apomorphine may potentiate the antihypertensive effects of antihypertensive products
Antihypertensives, apraclonidine [2] ---> SmPC of [2] of eMC
Since apraclonidine may reduce pulse and blood pressure, caution in using drugs such as antihypertensives
Antihypertensives, aripiprazole [2] ---> SmPC of [2] of EMA
Due to its alfa1 -adrenergic receptor antagonism, aripiprazole has the potential to enhance the effect of certain antihypertensive medicinal products.
Antihypertensives, asenapine [2] ---> SmPC of [2] of EMA
Because of its alfa1-adrenergic antagonism with potential for inducing orthostatic hypotension, asenapine may enhance the effects of certain antihypertensive agents.
Antihypertensives, atenolol
Concomitant use of atenolol with antihypertensive agents as well as other drugs with blood pressure lowering potential may increase the risk of hypotension.
Antihypertensives, atenolol/chlortalidone
Enhanced antihypertensive effect
Antihypertensives, atomoxetine
Atomoxetine may decrease the hypotensive effect and increase the blood pressure. Monitor closely the blood pressure.
Antihypertensives, atypical neuroleptics
The atypical neuroleptic may increase or decrease the effect of antihypertensive agent
Antihypertensives, avanafil [2] ---> SmPC of [2] of EMA
If avanafil is used in combination with another medicinal product which reduces systemic blood pressure, the additive effects may result in symptomatic hypotension (e.g. dizziness, light-headedness, syncope or near-syncope)
Antihypertensives, axitinib [2] ---> SmPC of [2] of EMA
Patients receiving antihypertensive medicinal products should be monitored for hypotension
Antihypertensives, baclofen [2] ---> SmPC of [2] of eMC
Concomitant use of baclofen with antihypertensives is likely to increase the fall in blood pressure, therefore the dosage of the antihypertensive medication should be adjusted accordingly.
Antihypertensives, barbiturates
Orthostatic hypotension may be aggravated
Antihypertensives, barnidipine
The co-administration of barnidipine with other antihypertensive may enhance the antihypertensive effect
Antihypertensives, benazepril
Benazepril may enhance the hypotensive effect of other antihypertensive drugs
Antihypertensives, bendroflumethiazide [2] ---> SmPC of [2] of eMC
Thiazides may enhance the effects of antihypertensive agents
Antihypertensives, benperidol
The risk of hypotension with antihypertensive drugs may be increased when benperidol is given concomitantly.
Antihypertensives, benzodiazepines
Enhanced hypotensive effects may occur when benzodiazepines is given to patients treated with antihypertensive agents.
Antihypertensives, betablockers
When combined with beta-blockers, drugs that decrease arterial pressure can cause or increase hypotension, notably orthostatic.
Antihypertensives, betaxolol
The combination may cause strong hypotension
Antihypertensives, bisoprolol [2] ---> SmPC of [2] of eMC
Concomitant use of bisoprolol with antihypertensive agents as well as with other medicinal products with blood pressure lowering potential may increase the risk of hypotension.
Antihypertensives, brexpiprazole [2] ---> SmPC of [2] of EMA
RXULTI may increase the effect of medicines used to lower the blood pressure.
Antihypertensives, brimonidine [2] ---> SmPC of [2] of EMA
Caution is advised when using medicinal products such as anti-hypertensives and/or cardiac glycosides concomitantly with brimonidine.
Antihypertensives, brinzolamide/brimonidine [2] ---> SmPC of [2] of EMA
Caution is advised when using medicinal products such as antihypertensives concomitantly with brinzolamide/brimonidine.
Antihypertensives, bromperidol
The co-administration may enhance the hypotensive effect
Antihypertensives, buflomedil
The co-administration may increase the hypotensive effect
Antihypertensives, bumetanide
Bumetanide may potentiate the effects of antihypertensive drugs.
Antihypertensives, bunazosin
Increased hypotensive effect
Antihypertensives, butyrophenones
Increased hypotensive effect
Antihypertensives, cabergoline
Hypotension
Antihypertensives, calcium antagonists
Diuretics potentiate the action of antihypertensive drugs
Antihypertensives, candesartan
Increased hypotensive effect
Antihypertensives, candesartan cilexetil [2] ---> SmPC of [2] of eMC
The antihypertensive effect of candesartan may be enhanced by other medicinal products with blood pressure lowering properties, whether prescribed as an antihypertensive or prescribed for other indications.
Antihypertensives, captopril [2] ---> SmPC of [2] of eMC
Concomitant use of other antihypertensive agents and captopril may increase the hypotensive effects of captopril.
Antihypertensives, carbetocin
Increased hypotensive effect
Antihypertensives, carbidopa
Symptomatic postural hypotension
Antihypertensives, carteolol
Enhanced hypotensive effect
Antihypertensives, carvedilol [2] ---> SmPC of [2] of eMC
Carvedilol may potentiate the effects of other concomitantly administered antihypertensives
Antihypertensives, cathine
Weakening of the hypotensive effect
Antihypertensives, celecoxib [2] ---> SmPC of [2] of EMA
NSAIDs may reduce the effect of antihypertensive medicinal products.
Antihypertensives, chlorpromazine [2] ---> SmPC of [2] of eMC
Potentiation of the antihypertensive effect and risk of orthostatic hypotension (additive effects).
Antihypertensives, chlorprothixene
The effect of antihypertensive drugs may be enhanced with the co-administration of chlorprothixene
Antihypertensives, chlortalidone
Diuretics potentiate the action of antihypertensive drugs
Antihypertensives, cilazapril [2] ---> SmPC of [2] of eMC
An additive effect may be observed when cilazapril is administered in combination with other antihypertensive agents.
Antihypertensives, cilostazol [2] ---> SmPC of [2] of EMA
Caution is needed when co-administering cilostazol with any other agent which has the potential to reduce blood pressure due to the possibility that there may be an additive hypotensive effect with a reflex tachycardia.
Antihypertensives, clofarabine [2] ---> SmPC of [2] of EMA
Patients taking medicinal products known to affect blood pressure should be closely monitored during treatment with clofarabine
Antihypertensives, clonidine [2] ---> SmPC of [2] of eMC
Concurrent administration of antihypertensive agents may lead to an increased hypotensive effect.
Antihypertensives, clopamide
Increased hypotensive effect
Antihypertensives, clozapine [2] ---> SmPC of [2] of eMC
Because of the possibility of additive effects, caution is essential in the concomitant administration of clozapine with substances possessing hypotensive effects
Antihypertensives, codergocrin
The co-administration may enhance the hypotensive effect
Antihypertensives, corticosteroids
The desired effects of antihypertensives are antagonized by corticosteroids
Antihypertensives, danazol [2] ---> SmPC of [2] of eMC
Possibly through promotion of fluid retention, danazol can oppose the action of anti-hypertensive agents.
Antihypertensives, deflazacort
The desired effects of antihypertensives are antagonized by corticosteroids
Antihypertensives, delapril [2] ---> SmPC of [2] of EMA
The co-administration may enhance the hypotensive effect
Antihypertensives, desflurane
Desflurane may potentiate the hypotensive effect when is administered with other antihypertensive drugs
Antihypertensives, desmopressin
Desmopressin may weaken the hypotensive effect
Antihypertensives, dexmedetomidine [2] ---> SmPC of [2] of EMA
The possibility of enhanced hypotensive and bradycardic effects should be considered in patients receiving other medicinal products causing these effects, for example beta blockers
Antihypertensives, diazoxide
Diazoxide may potentiate the effect of hypotensive drugs, what cause a further hypotension
Antihypertensives, diclofenac [2] ---> SmPC of [2] of eMC
Reduced antihypertensive effect
Antihypertensives, dihydralazine
The co-administration may increase the hypotensive effect
Antihypertensives, dihydrocodeine
The co-administration may enhance the sedative and respiratory depressor effect
Antihypertensives, dihydroergotoxine
The co-administration may enhance the hypotensive effect
Antihypertensives, diltiazem
Diltiazem may enhance the effect of co-administered antihypertensive agents
Antihypertensives, dimenhydrinate
The co-administration may enhance the hypotensive effect
Antihypertensives, dipyridamole [2] ---> SmPC of [2] of eMC
Dipyridamole may increase the hypotensive effect of drugs which reduce blood pressure
Antihypertensives, diuretics
Additive hypotensive effect
Antihypertensives, dixyrazine
Dixyrazine may enhance the hypotensive effect
Antihypertensives, doubutamine [2] ---> SmPC of [2] of eMC
Special care is advisable in patients receiving antihypertensive therapy in whom dobutamine may increase blood pressure.
Antihypertensives, doxazosin [2] ---> SmPC of [2] of eMC
Doxazosin potentiates the blood pressure lowering activity of other antihypertensives.
Antihypertensives, doxepin
The co-administration may enhance the hypotensive effect
Antihypertensives, droperidol [2] ---> SmPC of [2] of eMC
Droperidol may potentiate the action of antihypertensive agents, so that orthostatic hypotension may ensue.
Antihypertensives, dropropizine
The co-administration may enhance the hypotensive effect
Antihypertensives, empagliflozin/metformin [2] ---> SmPC of [2] of EMA
Based on the mode of action of SGLT-2 inhibitors, osmotic diuresis accompanying therapeutic glucosuria may lead to a modest decrease in blood pressure.
Antihypertensives, enalapril [2] ---> SmPC of [2] of eMC
Concomitant use of enalapril with other antihypertensive drugs may increase the hypotensive effects of enalapril.
Antihypertensives, enalapril/hydrochlorothiazide [2] ---> SmPC of [2] of eMC
Concomitant use of antihypertensive agents may increase the hypotensive effects of enalapril and hydrochlorothiazide.
Antihypertensives, eplerenone [2] ---> SmPC of [2] of eMC
Potassium-sparing diuretics may potentiate the effect of anti-hypertensive agents
Antihypertensives, eprosartan [2] ---> SmPC of [2] of eMC
The anti-hypertensive action of guanethidine may be enhanced by other anti-hypertensive agents.
Antihypertensives, esmolol [2] ---> SmPC of [2] of eMC
Concomitant administration of esmolol and other antihypertensive agents may increase the blood pressure lowering effect.
Antihypertensives, etomidate [2] ---> SmPC of [2] of eMC
Induction with etomidate may be accompanied by a slight and transient reduction in peripheral resistance which may enhance the effect of other drugs reducing blood pressure.
Antihypertensives, etoricoxib [2] ---> SmPC of [2] of eMC
NSAIDs may reduce the effect of antihypertensive drugs.
Antihypertensives, felodipine
Enhancement of the hypotensive effect of felodipine
Antihypertensives, felodipine/ramipril [2] ---> SmPC of [2] of eMC
Potentiation of the antihypertensive effect is to be anticipated.
Antihypertensives, fludrocortisone
Corticosteroids antagonise the effects of antihypertensives
Antihypertensives, flupentixol
Increased hypotensive effect
Antihypertensives, fluphenazine
Increased hypotensive effect
Antihypertensives, flurazepam [2] ---> SmPC of [2] of eMC
Enhancement of the central depressive effect may occur if benzodiazepines are combined with centrally-acting drugs
Antihypertensives, flurbiprofen [2] ---> SmPC of [2] of eMC
NSAIDs may reduce the effect of antihypertensive drugs
Antihypertensives, fluspirilene
The neuroleptic may enhance the hypotensive effect
Antihypertensives, fosinopril [2] ---> SmPC of [2] of eMC
Combination with of fosinopril with other anti-hypertensive agents may increase the anti-hypertensive effect.
Antihypertensives, furosemide [2] ---> SmPC of [2] of eMC
The co-administration may enhance the hypotensive effect
Antihypertensives, gallopamil
Enhancement of hypotensive effect
Antihypertensives, glucocorticoids
The mineralocorticoid effect of glucocorticoid antagonizes the antihypertensive effect, what can cause hypertension
Antihypertensives, glycerol trinitrate [2] ---> SmPC of [2] of eMC
Treatment with other agents with hypotensive effects may potentiate the hypotensive effect of glyceryl trinitrate.
Antihypertensives, glycerol trinitrate [2] ---> SmPC of [2] of eMC
Treatment with other agents with hypotensive effects may potentiate the hypotensive effect of glyceryl trinitrate.
Antihypertensives, guanethidine [2] ---> SmPC of [2] of eMC
The anti-hypertensive action of guanethidine may be enhanced by other anti-hypertensive agents.
Antihypertensives, guanfacin [2] ---> SmPC of [2] of EMA
Caution should be used when Intuniv is administered concomitantly with antihypertensive medicinal products, due to the potential for additive pharmacodynamic effects such as hypotension and syncope.
Antihypertensives, haloperidol
The co-administration may enhance the hypotensive effect
Antihypertensives, histamine dihydrochloride [2] ---> SmPC of [2] of EMA
Anti-hypertensive agents should be used with caution during treatment with histamine dihydrochloride. They may increase the toxicity of histamine dihydrochloride
Antihypertensives, hydralazine
The co-administration may increase the hypotensive effect
Antihypertensives, hydrochlorothiazide ---> SmPC of [amlodipine/valsartan/hydrochlorothiazide] of EMA
Thiazides potentiate the antihypertensive action of other antihypertensive drugs
Antihypertensives, hydrocodone
The co-administration of hydrocodone and other CNS depressants may enhance the sedative and respiratory depressor effects
Antihypertensives, hydroxyzine
The co-administration of antihypertensive agents with hydroxyzine may cause enhanced sedation
Antihypertensives, ibuprofen [2] ---> SmPC of [2] of EMA
NSAIDs may reduce the effect of antihypertensive medicinal products.
Antihypertensives, iloprost [2] ---> SmPC of [2] of EMA
Iloprost may increase the effects of vasodilatators and antihypertensive agents and then favour the risk of hypotension
Antihypertensives, imidapril [2] ---> SmPC of [2] of eMC
Concomitant use of antihypertensive agents and vasodilators with imidapril may increase the hypotensive effects of imidapril
Antihypertensives, indometacin
The co-administration may weaken the hypotensive effect
Antihypertensives, interleukin-2 [2] ---> SmPC of [2] of eMC
The co-administration may enhance the hypotension caused by aldesleukin.
Antihypertensives, irbesartan [2] ---> SmPC of [2] of EMA
Other antihypertensive agents may increase the hypotensive effects of irbesartan; however Aprovel has been safely administered with other antihypertensive agents, such as beta-blockers, long-acting calcium channel blockers, and thiazide diuretics.
Antihypertensives, irbesartan/hydrochlorothiazide [2] ---> SmPC of [2] of EMA
The antihypertensive effect may be increased with the concomitant use of other antihypertensive agents.
Antihypertensives, isocarboxazid
Concurrent administration of isocarboxazid with hypotensives agents may lead to potentiation of their effects.
Antihypertensives, isosorbide dinitrate [2] ---> SmPC of [2] of eMC
Concurrent intake of drugs with blood pressure lowering properties may potentiate the hypotensive effect
Antihypertensives, isosorbide mononitrate
The co-administration may potentiate the antihypertensive effect of isosorbide mononitrate
Antihypertensives, isradipine
The co-administration may enhance the hypotensive effect
Antihypertensives, ivabradine [2] ---> SmPC of [2] of EMA
Limited data are available in patients with mild to moderate hypotension, and ivabradine should therefore be used with caution in these patients. Ivabradine is contra-indicated in patients with severe hypotension (blood pressure < 90/50 mmHg)
Antihypertensives, kebuzone
The co-administration may weaken the hypotensive effect
Antihypertensives, ketamine [2] ---> SmPC of [2] of eMC
Concomitant use of antihypertensive agents and ketamine increases the risk of developing hypotension.
Antihypertensives, ketoprofen [2] ---> SmPC of [2] of eMC
Risk of decreased antihypertensive potency (inhibition of vasodilator prostaglandins by NSAIDs).
Antihypertensives, ketorolac [2] ---> SmPC of [2] of eMC
NSAIDs may reduce the effect of anti-hypertensive medicinal products.
Antihypertensives, labetalol
The co-administration may enhance the hypotensive effect
Antihypertensives, lacidipine [2] ---> SmPC of [2] of eMC
Co-administration of lacidipine with other agents recognised to have a hypotensive effect may have an additive hypotensive effect.
Antihypertensives, laropiprant/nicotinic acid [2] ---> SmPC of [2] of EMA
Nicotinic acid may potentiate the effects of ganglionic blocking agents and vasoactive medicinal products such as nitrates, calcium channel blockers, and adrenergic receptor blocking agents, resulting in postural hypotension.
Antihypertensives, levobunolol
The co-administration may potentiate the hypotensive effects of the beta blocker
Antihypertensives, levodopa ---> SmPC of [levodopa/carbidopa/entacapone] of EMA
Symptomatic postural hypotension may occur when levodopa is added to the treatment of patients already receiving antihypertensives. Dose adjustment of the antihypertensive agent may be required.
Antihypertensives, levodopa/benserazide ---> SmPC of [levodopa/carbidopa] of eMC
Postural hypotension can occur when levodopa is added to the treatment of patients already receiving antihypertensive drugs. Dosage adjustment of the antihypertensive agent may be required.
Antihypertensives, levodopa/carbidopa [2] ---> SmPC of [2] of EMA
Symptomatic postural hypotension has occurred when combinations of levodopa and a decarboxylase inhibitor are added to the treatment of patients already receiving certain antihypertensives.
Antihypertensives, levodopa/carbidopa/entacapone [2] ---> SmPC of [2] of EMA
Symptomatic postural hypotension may occur when levodopa is added to the treatment of patients already receiving antihypertensives. Dose adjustment of the antihypertensive agent may be required.
Antihypertensives, levodopa/DOPA decarboxylase inhibitors ---> SmPC of [levodopa/carbidopa] of eMC
Postural hypotension can occur when levodopa/carbidopa is added to the treatment of patients already receiving antihypertensive drugs. Dosage adjustment of the antihypertensive agent may be required.
Antihypertensives, levomepromazine
The co-administration may enhance the effect of antihypertensive agent
Antihypertensives, lisdexamfetamine [2] ---> SmPC of [2] of eMC
Amfetamines may decrease the effectiveness of antihypertensive medications.
Antihypertensives, lisinopril [2] ---> SmPC of [2] of eMC
Concomitant use of other antihypertensive agents may increase the hypotensive effects of lisinopril.
Antihypertensives, lisuride
Special caution should be exercised when prescribing lisuride for women who have taken or are taking drugs for blood pressure control.
Antihypertensives, loop diuretics
Enhancement of hypotensive effect
Antihypertensives, lorazepam [2] ---> SmPC of [2] of eMC
Enhanced hypotensive effect
Antihypertensives, lormetazepam
Enhanced hypotensive effects may occur when lormetazepam is given to patients treated with antihypertensive agents.
Antihypertensives, losartan [2] ---> SmPC of [2] of eMC
Other antihypertensive agents may increase the hypotensive effects of losartan.
Antihypertensives, losartan/hydrochlorothiazide [2] ---> SmPC of [2] of eMC
Concomitant use of losartan with drugs that lower blood pressure, as main or side-effect, may increase the risk of hypotension.
Antihypertensives, loxapine [2] ---> SmPC of [2] of EMA
Loxapine is not recommended in patient populations with conditions which would predispose patients to hypotension (dehydration, hypovolaemia, and treatment with antihypertensive medicinal products)
Antihypertensives, lumiracoxib
Reduced diuretic and antihypertensive effect of diuretic. Diuretic can increase the risk of nephrotoxicity of the NSAID
Antihypertensives, manidipine
The antihypertensive effect of manidipine can be enhanced by the co-administration of other antihypertensive drugs
Antihypertensives, mefruside
The co-administration may increase the antihypertensive effects
Antihypertensives, meloxicam
The co-administration may weaken the hypotensive effect
Antihypertensives, melperone
The co-administration of melperone and hypotensive drugs may enhance the hypotensive effect
Antihypertensives, methadone
Enhancement of methadone effect
Antihypertensives, methyldopa
The use of other antihypertensives may enhance the hypotensive effect.
Antihypertensives, methylphenidate [2] ---> SmPC of [2] of eMC
Methylphenidate may decrease the effectiveness of drugs used to treat hypertension.
Antihypertensives, methylprednisolone
The mineralocorticoid effect of glucocorticoid antagonizes the antihypertensive effect, what can cause hypertension
Antihypertensives, metipranolol
The co-administration may potentiate the hypotensive effects of the beta blocker
Antihypertensives, metolazone
The co-administration may cause an excessive decrease of the blood pressure
Antihypertensives, metoprolol [2] ---> SmPC of [2] of eMC
The effects of metoprolol and other antihypertensive drugs on blood pressure are usually additive, and care should be taken to avoid hypotension.
Antihypertensives, mianserin
It is recommended to monitor blood pressure
Antihypertensives, midazolam
Enhanced hypotensive effect
Antihypertensives, minoxidil [2] ---> SmPC of [2] of eMC
The effect of minoxidil may be additive to concurrent antihypertensive agents and other agents with blood pressure lowering effects.
Antihypertensives, moexipril
The co-administration of antihypertensive agents with moexipril gives rise to an enhanced antihypertensive
Antihypertensives, molsidomine
The co-administration may potentiate the hypotensive effect
Antihypertensives, moxonidine [2] ---> SmPC of [2] of eMC
Concurrent administration of other antihypertensive agents enhances the hypotensive effect of moxonidine
Antihypertensives, nabumetone [2] ---> SmPC of [2] of eMC
Diuretics and other antihypertensives drugs may present with decreased effect when concomitantly administered with NSAID
Antihypertensives, nadolol [2] ---> SmPC of [2] of eMC
Nadolol with antihypertensives may cause an additive hypotensive effect.
Antihypertensives, naftidrofuryl
Naftidrofuryl may potentiate the hypotensive effect
Antihypertensives, nalbuphine
The co-administration may cause symptoms of an orthostatic hypotension
Antihypertensives, narcotics
Orthostatic hypotension may be aggravated
Antihypertensives, neuroleptics
The hypotensive effect of most antihypertensive drugs especially alpha adrenoceptor blocking agents may be exaggerated by neuroleptics.
Antihypertensives, nicardipine [2] ---> SmPC of [2] of eMC
Nicardipine may be used in combination with beta-blocking and other anti-hypertensive drugs but the possibility of an additive effect resulting in postural hypotension should be considered.
Antihypertensives, nicergoline
Nicergoline may enhance the hypotensive effect of the coadministered hypotensive agents
Antihypertensives, nicomorphine
The co-administration may potentiate the hypotensive effect
Antihypertensives, nicorandil [2] ---> SmPC of [2] of eMC
If nicorandil is used concomitantly with antihypertensive agents or other medicinal products with blood-pressure-lowering effect the blood-pressure-lowering effect may be increased.
Antihypertensives, nifedipine [2] ---> SmPC of [2] of eMC
Nifedipine may be used in combined therapy with other antihypertensive agents including beta-blocker drugs, but the possibility of an additive effect resulting in postural hypotension should be borne in mind.
Antihypertensives, nilvadipine
Enhancement of hypotensive effect
Antihypertensives, nimesulide
The co-administration may weaken the hypotensive effect
Antihypertensives, nimodipine [2] ---> SmPC of [2] of eMC
Nimodipine may increase the blood pressure lowering effect of concomitant antihypertensives
Antihypertensives, nisoldipine
The co-administration may potentiate the hypotensive effect
Antihypertensives, nitrendipine
The co-administration may potentiate the hypotensive effect
Antihypertensives, nitroglycerine [2] ---> SmPC of [2] of eMC
Treatment with other agents with hypotensive effects may potentiate the hypotensive effect of glyceryl trinitrate.
Antihypertensives, nitroprussiate
Concomitant use of sodium nitroprusside with other antihypertensive agents may increase the antihypertensive effect
Antihypertensives, noradrenaline ---> SmPC of [norepinephrine] of eMC
Decreased antihypertensive effect
Antihypertensives, norepinephrine
Decreased antihypertensive effect
Antihypertensives, norpseudoephedrine
Weakening of the hypotensive effect
Antihypertensives, NSAID ---> SmPC of [parecoxib] of EMA
NSAIDs may reduce the effect antihypertensive medicinal products.
Antihypertensives, ofloxacin
The co-administration of ofloxacin i.v. with hypotensive agents may cause a sudden fall in blood pressure
Antihypertensives, olmesartan
The blood pressure lowering effect of olmesartan medoxomil can be increased by concomitant use of other antihypertensive medications.
Antihypertensives, olmesartan medoxomil [2] ---> SmPC of [2] of eMC
The blood pressure lowering effect of olmesartan medoxomil can be increased by concomitant use of other antihypertensive medications.
Antihypertensives, olmesartan medoxomil/amlodipine [2] ---> SmPC of [2] of eMC
The blood pressure lowering effects of amlodipine adds to the blood pressure-lowering effects of other antihypertensive agents.
Antihypertensives, oxaprozin
The co-administration may weaken the hypotensive effect
Antihypertensives, oxprenolol
The co-administration may enhance the hypotensive effect
Antihypertensives, oxytocin
Increased hypotensive effect
Antihypertensives, parecoxib [2] ---> SmPC of [2] of EMA
NSAIDs may reduce the effect antihypertensive medicinal products.
Antihypertensives, PDE5 inhibitors
The co-administration may cause symptomatic hypotension
Antihypertensives, penbutolol
The co-administration may potentiate the hypotensive effect
Antihypertensives, pentaerythritol tetranitrate
The co-administration may potentiate the hypotensive effect
Antihypertensives, pentoxifylline [2] ---> SmPC of [2] of eMC
Pentoxifylline may potentiate the effect of anti-hypertensive agents
Antihypertensives, perazine
The co-administration may enhance the hypotensive effect
Antihypertensives, pergolide
Because of the risk of postural and/or sustained hypotension in patients taking pergolide, caution should be exercised if it is co-administered with antihypertensive agents.
Antihypertensives, periciazine
The co-administration may enhance the hypotensive effect
Antihypertensives, perindopril [2] ---> SmPC of [2] of eMC
Concomitant use of antihypertensive may increase the hypotensive effects of perindopril.
Antihypertensives, perphenazine
Perphenazine may enhance the hypotensive effect of other antihypertensive medication.
Antihypertensives, phenothiazines
The hypotensive effect of most antihypertensive drugs especially alpha adrenoceptor blocking agents may be exaggerated by neuroleptics.
Antihypertensives, phenoxybenzamine
Phenoxybenzamine may potentiate the hypotensive effect
Antihypertensives, phenylbutazone
Phenylbutazone may weaken the hypotensive effect
Antihypertensives, phenylephrine [2] ---> SmPC of [2] of eMC
Phenylephrine may increase blood pressure and consequently reverse the action of many antihypertensive agents.
Antihypertensives, pholcodine [2] ---> SmPC of [2] of eMC
The reduction of blood pressure caused by antihypertensives may accentuate the hypotensive effects of pholcodine.
Antihypertensives, pimozide
The co-administration may enhance the hypotensive effect
Antihypertensives, pindolol
Concomitant use of beta-blockers with other anti-hypertensive agents may increase the blood pressure lowering effect.
Antihypertensives, pindolol/clopamide
Concomitant use of pindolol/clopamide and antihypertensive agents may increase the blood pressure lowering effect.
Antihypertensives, pipamperone
The co-administration may enhance the hypotensive effect
Antihypertensives, pipotiazine [2] ---> SmPC of [2] of eMC
The hypotensive effect of most antihypertensive drugs especially alpha adrenoceptor blocking agents may be exaggerated by neuroleptics.
Antihypertensives, piretanide
The hypotensor effect of piretanide may be potentiated
Antihypertensives, piroxicam [2] ---> SmPC of [2] of eMC
Antagonism of the hypotensive effect
Antihypertensives, potassium canrenoate
Increased hypotensive effect
Antihypertensives, potassium-sparing diuretics ---> SmPC of [eplerenone] of eMC
Potassium-sparing diuretics may potentiate the effect of anti-hypertensive agents
Antihypertensives, prazosin
The co-administration may enhance the hypotensive effect
Antihypertensives, prednisolone
The mineralocorticoid effect of glucocorticoid antagonizes the antihypertensive effect, what can cause hypertension
Antihypertensives, prednisone
Decreased antihypertensive effect (water and sodium retention of corticosteroids)
Antihypertensives, procainamide
The administration of high procainamide doses may cause additive hypotensive effects
Antihypertensives, proglumetacine
NSAIDs may reduce the effect of antihypertensive medicinal products.
Antihypertensives, promazine
The concomitant administration of promazine with antihypertensives may result in accentuation of their effects
Antihypertensives, promethazine
Possible effect enhancement of hypotensor
Antihypertensives, propofol
The co-administration of propofol with hypotensor medicines may have an additive effect
Antihypertensives, propranolol [2] ---> SmPC of [2] of EMA
When combined with beta-blockers, drugs that decrease arterial pressure can cause or increase hypotension, notably orthostatic.
Antihypertensives, prothipendyl
The combination of prothipendyl and antihypertensive agents may mutually enhance the effects
Antihypertensives, pseudoephedrine [2] ---> SmPC of [2] of eMC
Pseudoephedrine may antagonise the effects of antihypertensive agents
Antihypertensives, pyrazolones
The co-administration may change the effect of hypotensive agent
Antihypertensives, quinapril [2] ---> SmPC of [2] of eMC
There may be an additive effect or potentiation.
Antihypertensives, ramipril [2] ---> SmPC of [2] of eMC
Potentiation of the risk of hypotension is to be anticipated. Caution is recommended
Antihypertensives, risperidone [2] ---> SmPC of [2] of eMC
Clinically significant hypotension has been observed postmarketing with concomitant use of risperidone and antihypertensive treatment.
Antihypertensives, salicylates
Salicylate may reduce the effect of antihypertensive drugs.
Antihypertensives, silodosin [2] ---> SmPC of [2] of EMA
Caution should be exercised when starting concomitant use of silodosin with antihypertensives and patients should be monitored for possible adverse reactions.
Antihypertensives, sodium nitroprusside
Concomitant use of sodium nitroprusside with other antihypertensive agents may increase the antihypertensive effect
Antihypertensives, sotalol
The combination may enhance the hypotensive effect
Antihypertensives, spirapril
Additive hypotensive effect.
Antihypertensives, spironolactone [2] ---> SmPC of [2] of eMC
Potentiation of the effect of antihypertensive drugs occurs and their dosage may need to be reduced when spironolactone is added to the treatment regime
Antihypertensives, sulpiride [2] ---> SmPC of [2] of eMC
Antihypertensive effect and possibility of enhanced postural hypotension (additive effect).
Antihypertensives, tadalafil [2] ---> SmPC of [2] of EMA
Tadalafil (10 mg except for studies with angiotensin II receptor blockers and amlodipine in which a 20 mg dose was applied) had no clinically significant interaction
Antihypertensives, talinolol
The co-administration may cause a pronounced hypotension
Antihypertensives, tamsulosin
Possible enhanced hypotensive effects
Antihypertensives, tasonermin [2] ---> SmPC of [2] of EMA
Concurrent administration of agents likely to cause significant hypotension is not recommended
Antihypertensives, telmisartan [2] ---> SmPC of [2] of EMA
The blood pressure lowering effect of telmisartan can be increased by concomitant use of other antihypertensive medicinal products.
Antihypertensives, telmisartan/amlodipine [2] ---> SmPC of [2] of EMA
The blood pressure lowering effect of telmisartan/amlodipine can be increased by concomitant use of other antihypertensive medicinal products.
Antihypertensives, telmisartan/hydrochlorothiazide [2] ---> SmPC of [2] of EMA
Telmisartan may increase the hypotensive effect of other antihypertensive agents.
Antihypertensives, temazepam
Concomitant use of antihypertensive drugs and other CNS depressant drugs can mutually enhance the CNS depressant effects
Antihypertensives, tenoxicam ---> SmPC of [celecoxib] of EMA
Tenoxicam and other NSAIDs can reduce the effects of anti-hypertensive drugs.
Antihypertensives, terazosine [2] ---> SmPC of [2] of eMC
Caution is required when prescribing terazosin with other antihypertensive agents as significant hypotension has been observed.
Antihypertensives, terlipressin
The co-administration weakens the hypotensive effect
Antihypertensives, tetrabenazine
The co-administration of tetrabenazine with antihypertensive drugs may increase the risk of orthostatic hypotension
Antihypertensives, theodrenaline
Decrease of hypotensive effect
Antihypertensives, thiazides ---> SmPC of [amlodipine/valsartan/hydrochlorothiazide] of EMA
Thiazides potentiate the antihypertensive action of other antihypertensive drugs
Antihypertensives, thioridazine
The combination of antihypertensive and phenothiazines may inhibit the metabolism and increase the plasma levels of both active substances, what may cause severe hypotension, heart rhythm disorders and adverse reactions on the CNS
Antihypertensives, thioxanthenes
Increased hypotensive effect
Antihypertensives, tiapride
Antihypertensive effect and increased risk of orthostatic hypotension (additive effect)
Antihypertensives, timolol [2] ---> SmPC of [2] of eMC
Concomitant administration of timolol with antihypertensive agents may increase the blood pressure lowering effect.
Antihypertensives, tizanidine [2] ---> SmPC of [2] of eMC
As tizanidine may induce hypotension it may potentiate the effect of antihypertensive products, including diuretics, and caution should therefore be exercised in patients receiving blood pressure lowering products.
Antihypertensives, torasemid [2] ---> SmPC of [2] of eMC
As with other diuretics, the effect of antihypertensive drugs given concomitantly may be potentiated.
Antihypertensives, trandolapril [2] ---> SmPC of [2] of eMC
Combination of trandolapril with other antihypertensive agents may potentiate the antihypertensive response to trandolapril
Antihypertensives, trandolapril/verapamil [2] ---> SmPC of [2] of eMC
Antihypertensive medicinal products increase the hypotensive effect of trandolapril/verapamil
Antihypertensives, tranylcypromine
Tranylcypromine may potentiate the effects of antihypertensives
Antihypertensives, trapidil
Possible increase of hypotensive effect
Antihypertensives, trazodone [2] ---> SmPC of [2] of eMC
Hypotension, including orthostatic hypotension and syncope, has been reported to occur in patients receiving trazodone. Co-administration of hypotensor therapy with trazodone may require a reduction in the dose of the hypotensor drug
Antihypertensives, treprostinil
Concomitant administration of treprostinil with diuretics, antihypertensive agents or other vasodilators increases the risk of systemic hypotension.
Antihypertensives, triamcinolone acetonide [2] ---> SmPC of [2] of eMC
Corticosteroids antagonise the effects of antihypertensives and diuretics. The hypokalaemic effect of diuretics, including acetazolamide, is enhanced.
Antihypertensives, triamcinolone [2] ---> SmPC of [2] of eMC
Corticosteroids antagonise the effects of antihypertensives and diuretics. The hypokalaemic effect of diuretics, including acetazolamide, is enhanced.
Antihypertensives, triamterene
The combination likely enhances the hypotensive effect
Antihypertensives, triamterene/hydrochlorothiazide
Triamterene/hydrochlorothiazide may enhance the effect of other antihypertensive drugs.
Antihypertensives, tricyclic antidepressant
The co-administration may enhance the risk of orthostatic hypotension
Antihypertensives, trimipramine
Concomitant use of trimipramine and antihypertensive (except clonidine and related compounds) can increase the risk of orthostatic hypotension
Antihypertensives, urapidil
The antihypertensive effect of urapidil may be enhanced with the concomitant use of other antihypertensive drugs
Antihypertensives, valdecoxib
Decreased hypotensive effect.
Antihypertensives, valsartan
The blood pressure lowering effect can be increased
Antihypertensives, verapamil [2] ---> SmPC of [2] of eMC
Potentiation of the hypotensive effect
Antihypertensives, xipamide [2] ---> SmPC of [2] of eMC
The dosage of other hypotensive drugs may require adjustment when used in conjunction with xipamide
Antihypertensives, yohimbine
Antagonism of effects
Antihypertensives, zofenopril
Additive or enhanced hypotension may occur
Antihypertensives, zotepine
The co-administration may enhance the hypotensive effect
Antihypertensives, zuclopenthixol
Zuclopenthixol may increase or decrease the effect of antihypertensive agent
Betablockers, centrally-acting antihypertensives
When combined with beta-blockers, drugs that decrease arterial pressure can cause or increase hypotension, notably orthostatic.
Bisoprolol [1], centrally-acting antihypertensives ---> SmPC of [1] of eMC
Concomitant use of centrally-acting antihypertensive and bisoprolol may worsen heart failure by a decrease in the central sympathetic tonus (reduction of heart rate and cardiac output, vasodilation)
Carteolol, centrally-acting antihypertensives
Sudden withdrawal of central antihypertensive should be avoided if possible.
Celiprolol, centrally-acting antihypertensives
The co-administration may increase the hypotensive effect and the negative chronotropic and dromotropic effect
Centrally-acting antihypertensives, chlorpromazine [2] ---> SmPC of [2] of eMC
The co-administration may increase the CNS depressant effect
Centrally-acting antihypertensives, diphenhydramine
Concomitant use of diphenhydramine with central antihypertensive drugs may potentiate the fatigue
Centrally-acting antihypertensives, doxylamine
Enhanced sedation
Centrally-acting antihypertensives, flupentixol
Decreased antihypertensive effect
Centrally-acting antihypertensives, levobunolol
Enhanced hypotensive effect and additional bradycardia
Centrally-acting antihypertensives, melitracen
Melitracen may decrease the antihypertensive effect
Centrally-acting antihypertensives, metipranolol
Enhanced hypotensive effect and additional bradycardia
Centrally-acting antihypertensives, midazolam [2] ---> SmPC of [2] of EMA
The co-administration of midazolam with other sedative/hypnotic agents and CNS depressants, including alcohol, is likely to result in enhanced sedation and respiratory depression.
Centrally-acting antihypertensives, nebivolol [2] ---> SmPC of [2] of eMC
Concomitant use of nebivolol with centrally acting antihypertensive drugs may worsen heart failure by a decrease in the central sympathetic tonus (reduction of heart rate and cardiac output, vasodilation)
Centrally-acting antihypertensives, nortriptyline
Nortriptyline may decrease the antihypertensive effect
Centrally-acting antihypertensives, penbutolol
The combination may enhance the hypotensive effect and decrease the central sympathetic tonus (reduction of heart rate and cardiac output, vasodilation)
Centrally-acting antihypertensives, perphenazine
Possible weakening of the hypotensive effect
Centrally-acting antihypertensives, phenobarbital [2] ---> SmPC of [2] of eMC
Concurrent administration of phenobarbital with other CNS depressants may lead to additive CNS depressant effects
Centrally-acting antihypertensives, propranolol [2] ---> SmPC of [2] of EMA
When combined with beta-blockers, drugs that decrease arterial pressure can cause or increase hypotension, notably orthostatic.
Centrally-acting antihypertensives, sotalol
Bradycardia-inducing medicinal products enhance the risk of torsades de pointes
Centrally-acting antihypertensives, tiapride
Enhancement of CNS depressant effect
Centrally-acting antihypertensives, timolol
Enhancement of hypotensive effect and additional bradycardia
Centrally-acting antihypertensives, tramadol [2] ---> SmPC of [2] of eMC
Concomitant administration of tramadol with other centrally acting drugs may potentiate CNS depressant effects.
Centrally-acting antihypertensives, tricyclic antidepressant
The combination may potentiate the effect of tricyclic antidepressant and antidepressant may decrease the central hypotensive effect. The combination should be avoided
Centrally-acting antihypertensives, trimipramine
The co-administration of trimipramine with other CNS depressants may increase the CNS depressant effect.