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Essential Idea: The structure of DNA is ideally suited to its function
Essential Idea: The structure of DNA is ideally suited to its function
Understandings:
- Nucleosomes help to supercoil the DNA
- DNA structure suggested a mechanism for DNA replication
- DNA polymerases can only add nucleotides to the 3' end of a primer
- DNA replication is continuous on the leading strand and discontinuous on the lagging strand
- DNA replication is carried out by a complex system of enzymes
- Some regions of DNA do not code for proteins but have other important functions
Applications:
- Rosalind Franklin's and Maurice Wilkins' investigation of DNA structure by X-ray diffraction
- Use of nucleotides containing dideoxyribonucleic acid to stop DNA replication in preparation of samples for base sequencing
- Tandem repeats are used in DNA profiling
Skills:
- Skill: Analysis of results in Hershey and Chase experiment providing evidence that DNA is the genetic material
- Skill: Utilization of molecular visualisation software to analyse the association between protein and DNA within a nucleosome
Nature of science:
Making careful observations—Rosalind Franklin’s X-ray diffraction provided crucial evidence that DNA is a double helix.
Introductory video:
Introductory video:
Powerpoint
Powerpoint
7.1 DNA Structure & Replication.pptxUseful Videos
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