April 2025
Our review about the role of R-loops in neurodegeneration has been published in Current Opinions in Genetics and Development.
R-loops in neurodegeneration. Beghѐ C, Harpham H, Barberic Y, Gromak N.
Curr Opin Genet Dev. 2025 Jun;92:102345. doi: 10.1016/j.gde.2025.102345. Epub 2025 Apr 8. [REVIEW]
January 2025
We have Post-Doctoral and Research assistant positions available in the lab. Please apply here
Postdoctoral Research Assistant in R-loop biology - Dunn School
Research Assistant in Huntington’s disease - Dunn School
Deadline: 20th of January 2025
September 2024
Ela Tabbouche, a Part II (Masters) student in Biochemistry has joined the lab.
Welcome Ela!
September 2024
Our review about the role of RNA modifications in the DNA damage response has been accepted by Molecular Cell. This was a collaborative project between our lab, the lab of Blerta Xhemalce (University of Texas at Austin) and Kyle Miller (University of Texas at Austin).
Epitranscriptome in action: RNA modifications in the DNA damage response. Xhemalce B*, Miller KM*, Gromak N* (*-joint comm authors)
Molecular Cell. 2024 Oct 3;84(19):3610-3626. doi: 10.1016/j.molcel.2024.09.003. [ARTICLE]
September 2024
After completing her Biochemistry Degree in Oxford and her Part II (Master's project) in the lab, Yasmine Barberic has returned to Gromak lab as a Research Assistant. Welcome back, Yasmine!
July 2024
We have multiple Post-Doctoral positions available in the lab. Please apply here
Deadline: 22th of July 2024
July 2024
Gromak lab was awarded Gold LEAF award for environmental sustainability. Congratulations, everybody!!
October 2023
Martha Buhmann, a new PhD student, has joined the lab.
Welcome Martha!
September 2023
Our paper on the role of APOBEC3B in R-loop biology and cancer mutagenesis has been published by Nature Genetics. This was an epic collaborative project between our lab, the lab of Reuben Harris (UT Health San Antonio) and Kyle Miller (University of Texas). Fantastic effort from all 3 labs and perfect outcome!!!
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer. McCann JL**, Cristini A**, Law EK, Lee SY, Tellier M, Carpenter MA, Beghè C, Kim JJ, Sanchez A, Jarvis MC, Stefanovska B, Temiz NA, Bergstrom EN, Salamango DJ, Brown MR, Murphy S, Alexandrov LB, Miller KM*, Gromak N*, Harris RS*. (*-joint comm authors; **-joint first authors)
Nature Genetics. 2023 Sep 21. doi: 10.1038/s41588-023-01504-w [ARTICLE]
September 2023
Martine Palma, a new Post-Doctoral Fellow, has joined the lab.
Yasmine Barberic, a Part II (Masters) student in Biochemistry has joined the lab.
Welcome Martine and Yasmine!
July 2023
Gromak lab was awarded Gold LEAF award for environmental sustainability. Congratulations, everybody!!
February 2023
Alongside with other experts in the field, Natalia was invited by the Molecular Cell journal to share her opinion about research in the field of expansion repeat diseases. (Eric T Wang, Catherine H Freudenreich, Natalia Gromak, Ankur Jain, Peter K Todd, Yoshitaka Nagai. What repeat expansion disorders can teach us about the Central Dogma). [INVITED OPINION]
October 2022
We have a new Post-Doctoral position available in the lab. Please apply here https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10&p_internal_external=E&p_display_in_irish=N&p_process_type=&p_applicant_no=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y&p_recruitment_id=160964
September 2022
Helena Harpham, a new PhD student, has joined the lab.
Ella Wilszyc, a Part II (Masters) student in Biochemistry has joined the lab.
Welcome Ella and Helena!
July 2022
Gromak lab was awarded Gold LEAF award for environmental sustainability. Congratulations, everybody!!
May 2022
Our paper on the role of RNase H2 in transcription has been accepted for publication in Nature Communications (Cristini et al, RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation). Fantastic effort from all contributing authors! [ARTICLE]
January 2022
We are starting 2022 on a high note. Our collaborative paper with Kajaste-Rudnitski lab has been accepted for publication in Journal of Experimental Medicine (Giordano AMS et al, DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes)! Great effort from all the contributing authors. Congratulations, Maria Sole Giordano and Chiara Beghè! [ARTICLE]
The lab is attending RNA UK 2022 in the Lake District to present our most recent work on R-loops in diseases.
October 2021
After graduating with a 1st class degree from the Biochemistry course at the University of Oxford, Holly Roach has joined the lab as a Research Assistant. Welcome Holly!
June 2021
Lucas Cronin from the Universität Duisburg-Essen has joined the lab for a 3-months DAAD RISE internship. Welcome Lucas!
Our collaborative paper with the Hammond lab on R-loops in hypoxia has been accepted for publication in Nature Communications journal (Ramachandran S et al, Hypoxia-induced SETX links replication stress with the unfolded protein response). [ARTICLE]
April 2021
Elena Becker from the Freie Universität Berlin has joined the lab for a 4-months DAAD RISE internship. Welcome!
Dr. Maria Sole Giordano has joined our lab as a Post-Doctoral research fellow. Welcome!