Publications

What repeat expansion disorders can teach us about the Central Dogma.

Wang ET, Freudenreich CH, Gromak N, Jain A, Todd PK, Nagai Y.

Molecular Cell. 2023 Feb 2;83(3):324-329 . [Invited opinion] 

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation 

Cristini A, Tellier M, Constantinescu F, Accalai C, Albulescu LO, Heiringhoff R, Bery N, Sordet O, Murphy S, Gromak N

Nature Communications, 13, 2961 (2022). DOI : 10.1038/s41467-022-30604-0 [ARTICLE]

DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières Syndrome astrocytes

Giordano, A.M.S., Luciani, M., Gatto, F., Alezz, M.A., Beghè, C., Volpe, L.D., Migliara, A., Valsoni, S., Genua, M., Dzieciatkowska, M., Frati, G., Tahraoui-Bories, J., Giliani, S., Orcesi, S., Fazzi, E., Ostuni, R., D'Alessandro, A., Di Micco, R., Merelli, I., Lombardo, A., Reijns, M., Gromak, N., Gritti, A., and Kajaste-Rudnitski, A.

Journal of Experimental Medicine, 2022 Apr 4;219(4):e20211121. [ARTICLE]

R-loop immunoprecipitation - method to identify R-loop interactions in vivo

Beghè, C. and Gromak, N.

Methods in Molecular Biology, 022;2528:215-237. [ARTICLE] 

R-loop homeostasis and cancer mutagenesis promoted by DNA cytosine deaminase APOBEC3B

McCann**, J.L., Cristini**, A., Law, E.K., Lee, S.Y., Tellier, M., Carpenter, M.A., Beghè, C., Kim, J.J., Jarvis, M.C., Stefanovska, B., Temiz, N.A., Bergstrom, E.N., Salamango, D.J., Brown, M.R., Murphy, S., Alexandrov, L.B., Miller, K.M., Gromak*, N., Harris*, R.S. (*-joint comm authors; **-joint first authors)

BioRxiv, doi: 10.1101/2021.08.30.458235 [PREPRINT]

Hypoxia-induced SETX links replication stress with the unfolded protein response

Ramachandran, S., Ma, T.S., Griffin, J., Ng, N., Foskolou, I.P., Hwang, M.S., Victori, P., Cheng, W.C., Buffa, F.M., Leszczynska, K.B., El-Khamisy, S.F., Gromak, N., Hammond, E.M.

Nature Communications, 2021 Jun 17;12(1):3686. [ARTICLE]

Transcription-dependent DNA double-strand breaks and human disease

Cristini, A., Gromak, N., Sordet, O.

Molecular and Cellular Oncology, 2020 Jan 10;7(2):1691905. [REVIEW]

N 6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

Abakir, A., Giles, T.C., Cristini, A., Foster, J.M., Dai, N., Starczak, M., Rubio-Roldan, A., Li, M., Eleftheriou, M., Crutchley, J., Flatt, L., Young, L., Gaffney, D.J., Denning, C., Dalhus, B., Emes, R.D., Gackowski, D., Corrêa, I.R., Garcia-Perez, J.L., Klungland*, A., Gromak*, N., Ruzov*, A. (*-joint comm authors)

Nature Genetics, 2020 Jan;52(1):48-55. [ARTICLE]

Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks

Cristini, A., Ricci, G., Britton, S., Salimbeni, S., Huang, S. yin N., Marinello, J., Calsou, P., Pommier, Y., Favre, G., Capranico, G., Gromak*, N., Sordet*, O. (*-joint comm authors)

Cell Reports, 2019 Sep 17;28(12):3167-3181.e6. [ARTICLE]

RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage

Cristini*, A., Groh*, M., Kristiansen, M.S., Gromak, N. (*-joint first authors)

Cell Reports, 2018 May 8;23(6):1891-1905. [ARTICLE]

Large XPF-dependent deletions following misrepair of a DNA double strand break are prevented by the RNA:DNA helicase Senataxin

Brustel, J., Kozik, Z., Gromak, N., Savic, V., Sweet, S.M.M.

Scientific Reports, 2018 Mar 1;8(1):3850. [ARTICLE]

Senataxin: genome guardian at the interface of transcription and neurodegeneration

Groh, M., Albulescu, L.O., Cristini, A., Gromak, N. 

Journal of Molecular Biology, 2017 Oct 27;429(21):3181-3195. [REVIEW] 

Increased global transcription activity as a mechanism of replication stress in cancer

Kotsantis, P., Silva, L.M., Irmscher, S., Jones, R.M., Folkes, L., Gromak*, N., Petermann*, E. (*-joint comm authors) 

Nature Communications, 2016 Oct 11;7:13087. [ARTICLE] 

Out of balance: R-loops in human disease

Groh, M., Gromak, N. 

PLoS Genetics, 2014 Sep 18;10(9):e1004630. [REVIEW] 

Mechanisms of transcriptional dysregulation in repeat expansion disorders

Groh, M., Silva, L.M., Gromak, N. 

Biochemical Society Transactions, 2014 Aug;42(4):1123-8. [REVIEW] 

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich Ataxia and Fragile X Syndrome

Groh, M., Lufino, M.M.P., Wade-Martins, R., Gromak, N. 

PLoS Genetics, 2014 May 1;10(5):e1004318. [ARTICLE] 

Drosha regulates gene expression independently of RNA cleavage function

Gromak*, N., Dienstbier, M., Macias, S., Plass, M., Eyras, E., Cáceres, J.F., Proudfoot*, N.J. (*-joint comm authors)

Cell Reports, 2013 Dec 26;5(6):1499-510. [ARTICLE] 

Intronic microRNAs: A crossroad in gene regulation

Gromak, N. 

Biochemical Society Transactions, 2012 Aug;40(4):759-61. [REVIEW] 

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination

Skourti-Stathaki, K., Proudfoot*, N.J., Gromak*, N. (*-joint comm authors)

Molecular Cell, 2011 Jun 24;42(6):794-805. [ARTICLE]