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Principal Investigator, MD, PhD, PU-PH, Université Paris Cité, AP-HP
Biography
Biography
After studying physics at the Ecole Normale Supérieure in Lyon and obtaining a PhD in quantum physics, Emmanuel Mandonnet began his medical studies in 2000 at the Paris 5 University. As an intern in neurosurgery at the Paris hospitals from 2003 to 2008, he developed, in parallel, a research activity centered on the biomathematical modeling of gliomas growth. Since 2015, he has been a university professor in the neurosurgery department of the Lariboisière Hospital, where he is involved in surgery on intracerebral tumors (gliomas, metastases). He is particularly specialized in "awake" surgery, in order to optimize the preservation of cognitive functions. Having obtained an INSERM interface contract in 2018 within the Frontlab at the Brain Institute, he now focuses his research on electrophysiological and functional aspects of intracerebral surgeries: recordings and interpretation of intraoperative evoked potentials, pre- and postoperative assessments of high-level cognitive functions, predictive tools for postoperative cognitive and socio-professional outcomes based on preoperative cognitive and imaging data (resting fMRI, tractography).
Main research indices: h-factor = 47, pubmed indexed papers = 158.
Research work
Research work
- prediction of the effects of surgical resection on cognitive functions using machine learning methods
- deciphering brain connections using the intraoperative evoked potentials method
- exploration of high-level cognitive functions (creativity, decision making in relation to fatigability, ...) in patients followed for a brain tumor
- multimodal methods (functional and structural connectivity MRI, evoked potentials and intraoperative cognitive mapping) for the exploration of brain networks
Publications
Publications
Facque V, Wiehler A, Volle E, Mandonnet E, Pessiglione M. Present bias in economic choice demonstrates increased cognitive fatigability of glioma patients. Cortex. 2022 Jun;151:281-293. doi: 10.1016/j.cortex.2022.02.015. Epub 2022 Mar 29. PMID: 35462205.
Barberis M, Poisson I, Facque V, Letrange S, Prevost-Tarabon C, Houdart E, Froelich S, Levy R, Mandonnet E. Group-level stability but individual variability of neurocognitive status after awake resections of right frontal IDH-mutated glioma. Sci Rep. 2022 Apr 12;12(1):6126. doi: 10.1038/s41598-022-08702-2. PMID: 35413966; PMCID: PMC9005659.
Mrah S, Descoteaux M, Wager M, Boré A, Rheault F, Thirion B, Mandonnet E. Network-level prediction of set-shifting deterioration after lower-grade glioma resection. J Neurosurg. 2022 Mar 4:1-9. doi: 10.3171/2022.1.JNS212257. Epub ahead of print. PMID: 35245898.
Mandonnet E, Thirion B. Tackling the Complexity of Lesion-Symptoms Mapping: How to Bridge the Gap Between Data Scientists and Clinicians? Acta Neurochir Suppl. 2022;134:195-203. doi: 10.1007/978-3-030-85292-4_23. PMID: 34862543.
Boyer A, Stengel C, Bonnetblanc F, Dali M, Duffau H, Rheault F, Descoteaux M,Guiraud D, Valero-Cabre A, Mandonnet E. Patterns of axono-cortical evoked potentials: an electrophysiological signature unique to each white matter functional site? Acta Neurochir (Wien). 2021 Jan 12. doi: 10.1007/s00701-020-04656-4. Epub ahead of print. PMID: 33433683.
Wasserman D, Valero-Cabré A, Dali M, Stengel C, Boyer A, Rheault F, Bonnetblanc F, Mandonnet E. Axono-cortical evoked potentials as a new method of IONM for preserving the motor control network: a first study in three cases. Acta Neurochir (Wien). 2021 Apr;163(4):919-935. doi: 10.1007/s00701-020-04636-8. Epub 2020 Nov 7. PMID: 33161475.
Mandonnet E, Vincent M, Valero-Cabré A, Facque V, Barberis M, Bonnetblanc F, Rheault F, Volle E, Descoteaux M, Margulies DS. Network-level causal analysis of set-shifting during trail making test part B: A multimodal analysis of a glioma surgery case. Cortex. 2020 Nov;132:238-249. doi: 10.1016/j.cortex.2020.08.021. Epub 2020 Sep 12. PMID: 33007639.
Mandonnet E, Margulies D, Stengel C, Dali M, Rheault F, Toba MN, Bonnetblanc F, Valero-Cabre A. "I do not feel my hand where I see it": causal mapping of visuo-proprioceptive integration network in a surgical glioma patient. Acta Neurochir (Wien). 2020 Aug;162(8):1949-1955. doi: 10.1007/s00701-020-04399-2. Epub 2020 May 13. PMID: 32405668.
Corrivetti F, de Schotten MT, Poisson I, Froelich S, Descoteaux M, Rheault F, Mandonnet E. Dissociating motor-speech from lexico-semantic systems in the left frontal lobe: insight from a series of 17 awake intraoperative mappings in glioma patients. Brain Struct Funct. 2019 Apr;224(3):1151-1165. doi: 10.1007/s00429-019-01827-7. Epub 2019 Jan 14. PMID: 30637492.
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