Official Guide - Collectibles

Ceres
"Self-care..."

This item has replaced Charm of the Vampire.

Changes: In addition to its vanilla effects, taking contact damage now causes the entity hurting Isaac to begin Bleeding

Cupido
"Companionship..."

This item has replaced Zodiac. There have been no changes to its vanilla effects.

Cricket's Collar
"Missing..."

This item has replaced Cricket's Head.

Changes: In addition to its vanilla effects, now decreases Speed and Shotspeed

Dad's Key
"Opens all doors..."

Changes: This item can now unlock Golden and Stone chests

Guppy's Body
"Knocking on death's door..."

This item has replaced Dead Cat.

Changes: This item no longer spawns a familiar.

Isaac's Tears
"Collected tears"

Changes: This item is now used automatically when fully charges

Ixion
"Lawlessness..."

This item has replaced Playdough Cookie.

Changes: In addition to its vanilla effects, now has a chance to activate one of the following Dice when entering a new room:

Lot
"Fortune..."

This item has replaced Deep Pockets. There have been no changes to its vanilla effects.

Mandatum Impiorum
"Commandment for the Wicked"

This item has replaced Abaddon.

Changes: In addition to its vanilla effects, now has a chance to deal 40 damage to enemies in the room.

Mark of Asmodeus
"Gift of Lust"

This item has replaced Hungry Soul.

Changes: In addition to its vanilla effects, taking contact damage causes the enemy hurting Isaac to become charmed for 10 seconds

Mark of Beelzebub
"Gift of Gluttony"

This item has replaced Binge Eater.

Changes: In addition to its vanilla effects, caps Speed at 1.0 and increases size.

Mark of Belphegor
"Gift of Sloth"

This item has replaced Sanguine Bond.

Changes: In addition to its vanilla effects, taking an item in a devil room increases future devil deal chances by 5%, and guarantees a devil room will spawn on the Cathedral/Sheol floor

Mark of Cain
"Darkness courses through me..."

This item has replaced Lusty Blood.

Changes: In addition to its vanilla effects, now rerolls all neutral pills into positive pills.

Mark of Leviathan
"Gift of Envy"

This item has replaced Bloody Gust.

Changes: In addition to its vanilla effects, taking damage now pauses the current room until Isaac shoots

Mark of Lucifer
"Gift of Pride"

This item has replaced Hypercoagulation.

Changes: In addition to its vanilla effects, now has a 25% chance to remove a newly-spawned heart, regardless of its source

Mark of Mammon
"Gift of Greed"

This item has replaced Money = Power.

Changes: In addition to its vanilla effects, has a chance to replace special coins with a single Penny

Mark of Satan
"Gift of Wrath"

This item has replaced Bloody Lust.

Changes: In addition to its vanilla effects, now causes Isaac to explode when taking damage

Meat Cleaver
"Slice but no dice"

Changes: In addition to its vanilla effects, now deals damage to end-game bosses equal to 25% of their maximum health and causes Bleeding

Minotaur Horn
"Cut from a Labyrinthian"

This item has replaced Wooden Spoon.

Changes: In addition to its vanilla effects, now prevents Curse of the Labyrinth, Curse of the Lost, and Curse of the Maze from appearing on future floors

Moxie's Eye
"Imaginary friends..."

This item has replaced Mom's Wig.

Changes: In addition to its vanilla effects, has a luck-based chance to spawn a Blue Fly while firing (or charging)

This item no longer heals a red heart on pickup.

Moxie's Head
"A feast for the maggots..."

This item has replaced Guppy's Head.

Changes: In addition to its vanilla effects, now has a chance to replace Red hearts with Rotten hearts while held

Moxie's Paw
"Give to be given..."

This item has replaced Box of Spiders.

Changes: In addition to its vanilla effects, now causes half a heart of damage to Isaac, and will replace any core pickups in the room with Blue Flies

Omerta
"Thirty pieces of silver..."

This item has replaced Judas' Shadow.

Changes: In addition to its vanilla effects, now gives 30 coins on pickup

Pallas
"Patience and strategy..."

This item has replaced Gnawed Leaf.

Changes: In addition to its vanilla effects, now removes the time limit to enter Boss Rush or the Blue Womb floor.

Petrified Heart
"I think I'm dying..."

This item has replaced Adrenaline.

Changes: In addition to its vanilla effects, now immediately removes almost all Red health, leaving only half a heart

Plastic Shovel
"For the sandbox..."

This item has replaced Wooden Nickel.

Changes: In addition to its vanilla effects, now has a chance to spawn a different core pick-up, rather than a Coin

Sanctum Mandatum
"Commandment for the Righteous"

This item has replaced Holy Grail.

Changes: In addition to its vanilla effects, now prevents flight from being removed by any source.

Serpent of Eden
"Embodiment of Temptation"

This item has replaced Serpent's Kiss.

Changes: In addition to its vanilla effects, now causes tears to wiggle back and forth when fired

Skull Chalice
"Blood of my enemies..."

This item has replaced Brittle Bones.

Changes: In addition to its vanilla effects, now has a chance to replace pedestals with an item from Houngan's Voodoo pool

Tammy's Body
"Crawling with parasites..."

This item has replaced The Parasite.

Changes: In addition to its vanilla effects, now decreases Shotspeed

Typhon
"The storm inside..."

This item has replaced Depression.

Changes: This item now spawns several pillars of light (similar to Crack the Sky) when Isaac takes damage.

Vesta
"The fire within..."

This item has replaced Fire Mind.

Changes: This item now sets enemies on fire and puts out any fires in the room when Isaac takes damage.

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