Effects: In addition to its vanilla effects, this card now deals damage to bosses equal to 10% of their maximum Health. If they are killed by this damage, a pickup related to the card will be spawned.

Effects: This card no longer spawns hearts on the floor, and instead causes the next chest opened to reward 5 hearts; excludes Red Chests

This card has replaced Get Out of Jail Free. There have been no changes to its vanilla effects.

Changes: This pill now requires Isaac to take another within thirty seconds, else it causes a half heart of damage

Changes: This pill now causes the screen to warp and distort (similar to using Wavy Cap); this effect remains until Isaac clears two rooms