Effect: When entering a new floor, has a chance to spawn a key in the starting room; there is a small chance this is replaced with a golden key
When holding Mom's Box, these chances are doubled
Effect: When entering a new floor, has a chance to spawn a bomb in the starting room; there is a small chance this is replaced with a golden bomb
When holding Mom's Box, these chances are doubled
Effect: If Isaac has no Soul Hearts when entering a new floor, spawns a Soul Heart in the starting room
When holding Mom's Box, a Soul Heart will be spawned regardless of Isaac's health
Effect: When entering a new room, has a luck-based chance to apply Poison to enemies for a short time
When holding Mom's Box, this chance is doubled
Effect: When entering a new room, has a luck-based chance to apply Fear to enemies for a short time
When holding Mom's Box, this chance is doubled
Effect: When entering a new floor, has a chance to spawn a random core pick-up in the starting room; there is a small chance Isaac instead receives one of each core pick-up
When holding Mom's Box, these chances are doubled
Effect: When entering a new room, has a luck-based chance to apply Midas Freeze to enemies for a short time
When holding Mom's Box, this chance is doubled
Effect: When entering a new room, has a luck-based chance to apply Magnetized to some enemies
When holding Mom's Box, this chance is doubled
Effect: While held, automatically unlocks and opens Library doors
Effect: When entering a new room, has a luck-based chance to apply Charm to enemies for a short time
When holding Mom's Box, this chance is doubled
Effect: When entering a new room, has a luck-based chance to apply Baited to some enemies
When holding Mom's Box, this chance is doubled
Effect: When entering a new room, has a luck-based chance to apply Bleed to some enemies
When holding Mom's Box, this chance is doubled
Effect: Increases Luck; each time Isaac takes damage on the floor, this bonus decreases, and is reset at the start of the next floor.
Has a chance to spawn after defeating a boss if Isaac is not awarded with Perfection or a health upgrade
Effect: When entering a new room, has a luck-based chance to apply Slow to some enemies for a short time
When holding Mom's Box, this chance is doubled
Effect: When entering a new room, has a luck-based chance to apply Freeze to enemies for a short time
When holding Mom's Box, this chance is doubled
Effect: When entering a new room, has a luck-based chance to apply Shrink to enemies for a short time
When holding Mom's Box, this chance is doubled
Effect: Increases Luck
When holding Mom's Box, this bonus is doubled
Effect: When entering a new room, has a luck-based chance to apply Shrink to enemies for a short time
When holding Mom's Box, this chance is doubled