• Ethics around the issues of fairness if one group receives treatment while the other group does not

• RCTs should only be done when there is not significant knowledge whether the intervention is beneficial

• Imperative participants have informed consent of risks and benefits

• There must be zero evidence of coercion or deception while encouraging participation

• There must be clear protocols in place to end the trail if safety or harm to participants occurs

(Unicef Innocenti, 2015)