Merkel Cell Polyomavirus
Merkel Cell Polyomavirus
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Left) Merkel cell carcinoma (MCC), fast growing nodule on an extremity (lesions which could also be observed in patient’s head or neck)Right) Light micrograph of sample stained with hematoxylin and eosin showed histological appearance of MCC (round cells with scant cytoplasm, neuroendocrine chromatin and multiple mitotic figures, shown with arrows). Also shows trabecular patterning. (Harms et al., 2018)
Raccoon Polyomavirus
Raccoon Polyomavirus
Gross pathology, head of raccoon no. 9 (Rac9), left parasagittal section. The tumor destroys left olfactory tract and invades the left frontal lobe to the level of the midbrain. The tumor compresses the brain and distorts the cerebellum, (raccoon head in length, crown to nose, is 16 cm) (Dela Cruz et al., 2013).
Hematoxylin and eosin staining for Rac5 shows anisokaryosis and anisocytosis (Dela Cruz et al., 2013).
Goose Hemorrhagic Polyomavirus
Goose Hemorrhagic Polyomavirus
Evolution of Hemorrhagic nephritis enteritis of 8 week geese: macroscopic image of kidney, severe swelling and hemorrhage (Lacroux et al., 2004).
BK Polyomavirus
BK Polyomavirus
Tubular epithelial cells from renal transplant case show enlarged, basophilic, smudgy viral inclusions representative of BK polyoma virus nephropathy. (Jones' Silver Stain, original magnification X1000) (Atlas of Renal Pathology).
BKPyV infected tubular cell with intranuclear inclusion (Chikeka et al., 2016).
Trichodysplasia spinulosa-associated polyomavirus (Human polyomavirus 8)
Facial picture with thickened skin, concentrated around the nose and in the eyebrows, along with central alopecia. Papules are seen eyebrows, nose, cheeks, chin, forehead and ears. There are keratotic spicules ‘protruded from enlarged follicular orifices’ on the nose, and slightly on cheeks and chin (Van der Meijden et al., 2010).
"Section of a formalin-fixed, paraffin-embedded biopsy of a hyperkeratotic follicular papule from the forehead. The epidermis reveals enlarged, hyperplastic hair bulbs and hypercornification within a distended follicular infundibulum (HE stain, 10×)" (Van der Meijden et al., 2010).
JC Polyomavirus
"A: Classic PML: demyelinating lesion of the white matter (arrow) surrounded by multiple JCV-infected glial cells (arrowheads).B: JCV GCN: JCV infection of granule cell neurons (arrows).C: PML-IRIS: marked lymphocytes penetrating the perivascular region (arrows).D: JCV encephalopathy: JCV infected (arrow) hemispheric cortical neurons (arrowhead)."(Tan and Koralnik, 2010)
Rattus norvegicus polyomavirus 2
Rattus norvegicus polyomavirus 2
Figure A shows lesions in lung sections of X-SCID rats infected with Pneumocystis carinii. "Bronchi are filled with neutrophils, mucous, foamy macrophages ,and cell debris"Figure B shows bronchioles filled with similar material as bronchi. (Rigatti et al., 2016)
Biopsy taken 20 months after transplantation. Green arrows depict pleomorphic epithelial cells and associated mixed interstitial inflammation. Inset shows immunohistochemistry for the SV40 antigen, with strong nuclear staining in infected cells (Liptak et al., 2006).
Human Polyomavirus 7
Human Polyomavirus 7
Figures show (HPyV7)-related skin manifestations in patient. Figure A shows “rownish pink, scaly, thin papules and plaques involving the gluteal cleft and back, with progression up to the neck and chest but sparing acral areas and the face” (Ho et al., 2015).
Figure B shows skin biopsy specimen with “epidermal histopathologic pattern resembling peacock plumage, with plump, eosinophilic keratinocytes containing viral inclusions at different levels of the epidermis [and] an expanded stratum corneum with clusters of nucleated keratinocytes was present” (Ho et al., 2015).
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