Genome Maps

Major capsid protein of polyomavirus; 72 pentamers of VP1 comprise the outer capsid and form a T = 7 icosahedral lattice; VP1 contains an amino-terminal bipartite nuclear targeting signal that overlaps its DNA-binding-domain; The polyomaviruses are non-enveloped dsDNA viruses with a major capsid protein, VP1, that facilitates binding of genomic DNA and entry into target cells; the viral genome is organized into two divergent transcriptional units known as early and late regions; mRNAs from the early region encode the viral small and large t-antigens; mRNAs from the late region encode the structural proteins, VP1, VP2 and VP3

Promotes the efficient replication of genomic DNA; binds to and negatively regulates the function of protein phosphotase (PP2A) thereby accelerating the progression to S-phase; the small T antigen is not essential for replication in all cell lines

Binds to the viral origin of replication; regulates the transcription of early region mRNA; helicase activity facilitates movement of the virion DNA replication fork; the small T antigen shares a region in common with the large T antigen known as the J-domain; the J-domain is required for multiple processes including assembly, viral genomic DNA replication and transcription; The polyomaviruses are non-enveloped dsDNA viruses; the viral genome is organized into two divergent transcriptional units known as early and late regions; mRNAs from the early region encode the viral small and large t-antigens; the small T antigen and large T antigen are expressed upon entry into the host nucleus early in the viral lifecycle