A: The supplements are generally considered to be safe if you have histamine issues. That said, Rootcology’s beef protein powders contain collagen in the Hydrobeef. In some individuals, collagen can cause a histamine reaction, which may include symptoms like headaches, skin flushing, anxiety, irritability, stomach aches, etc. For more guidance on histamine intolerance, please review my article on Histamine and Hashimoto’s. Holy Basil added to the smoothies may be helpful as it tends to lower histamine levels in the body, as well as removing high histamine foods and substituting with low histamine foods.