Publications

1. Rajesh Singh, Geeta Upadhyay, Amit Kapoor, Sanjeev Kumar, Ashok Kumar, Meenakshi Tiwari and Madan M. Godbole (2002) Hypothyroidism alters expression of Bcl-2 family genes to induce apoptosis in rat developing cerebellum.  J Endocrinology 176(1): 39-46. (UGC Care No. 7315, ISSN: 220795, PMID: 12525248)

2. Rajesh Singh, Geeta Upadhyay and Madan M. Godbole (2002) Hypothyroidism alters mitochondrial morphology to induce release of apoptogenic proteins in developing rat cerebellum. J Endocrinology 176(3):321-329. (UGC Care No. 7315, ISSN: 220795, PMID: 12630917)

3. Geeta Upadhyay, Rajesh Singh, Gaurav Agarwal, Lily Pal, Pradahn PK, Das BK, Saroj K. Misra and Madan M. Godbole (2002) Enhanced Expression of Sodium Iodide Symporter (hNIS) Gene in human breast carcinoma tissue. Breast Can Res Treatment 77:157-165. (PMID: 12602914, ISSN: 0167-6806)

4. Geeta Upadhyay, Rajesh Singh, Ramesh Sharma, Anil K Balapure, Madan M. Godbole (2002) Iodine acts directly on mitochondria from tumoral breast tissue to induce apoptosis independent of cytochrome c. Mitochondrion2(3):199-210 (PMID: 16120321, ISSN: 1567-7249)

5. Geeta Upadhyay, Rajesh Singh, Amit Kapoor, Sanjeev Kumar, Ashok Kumar, Menakshi Tiwari and Madan M. Godbole (2004) Severe hyperthyroidism induces mitochondrial-mediated apoptosis in rat liver. Hepatalogy39(4):1120-30 (ISSN: 0270-9139).

6. Gupta S, Singh R*, Datta P, Zhang Z, Orr C, Lu Z, DuBois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2004) The carboxy terminal tail of presenilin regulates Omi/HtrA2 protease activity.  J Biol Chem. Oct 29;279(44):45844-54 (PMID: 15294909, ISSN: 0021-9258). 

7. Kumar A, Sinha RA, Tiwari M, Pal L, Shrivastava A, Singh R, Kumar K, Kumar Gupta S, Godbole MM.(2006) Increased pro-Nerve Growth Factor and p75NTR levels in developing hypothyroid rat cerebral cortex are associated with enhanced apoptosis. Endocrinology 2006 Oct;147 (10):4893-903.(ISSN: 0013-7227) 

8. Kumar A, Sinha RA, Tiwari M, Singh R, Koji T, Manhas N, Rastogi L, Pal L, Shrivastava A, Sahu RP, Godbole MM. Hyperthyroidism induces apoptosis in rat liver through activation of death receptor-mediated pathways. J Hepatol. 2007 May;46(5):888-98. Epub 2007 Feb 5 (PMID: 17321637, ISSN: 0168-8278). 

9. Patel, D., M. P. Suthar, V. Patel, and R. Singh. “BCR ABL KINASE INHIBITORS FOR CANCER THERAPY”. International Journal of Pharmaceutical Sciences and Drug Research, Vol. 2, no. 2, Apr. 2010, pp. 80-90. (ISSN: 0975-248X)

10. Tomar D, Singh R, Singh AK, Pandya CD, Singh R*. TRIM13 regulates ER stress induced autophagy and clonogenic ability of the cells. Biochim Biophys Acta. (Mol Cell Res) 2011 Dec 8;1823(2):316-326. [PMID: 22178386], ISSN: 0167-4889

11. Singh AK, Singh R, Tomar D, Pandya CD, Singh R* (2012) The Leucine aminopeptidase of Staphylococcus aureus is secreted and contributes to biofilm formation. Int J Infect Dis. 2012 May;16(5):e375-81. Epub 2012 Mar 10. (ISSN: 1201-9712)

12. Sripada L, Tomar D, Prajapati P, Singh R, Singh AK, Singh R* (2012) Systematic Analysis of Small RNAs Associated with Human Mitochondria by Deep Sequencing: Detailed Analysis of Mitochondrial Associated miRNA. PLoS ONE 7(9): e44873. (ISSN: 1932-6203)

13. Tomar D Prajapati P, Sripada L, Singh R, Singh AK, Singh R* (2012) Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway. PLoS One2012;7(11):e48662. (ISSN: 1932-6203)

14.  Sripada L, Tomar D, Singh R* (2012). Mitochondria: One of the destination of miRNA. MitochondrionNov;12(6):593-9 (PMID: 23085198, ISSN: 1567-7249)

15. Tomar D Prajapati P, Sripada L, Singh R, Singh AK, Singh R* (2013) TRIM13 regulates caspase-8 ubiquitination, translocation to autophagosomes and activation during ER stress induced cell death. Biochim Biophys Acta. 2013 Sep 8;1833(12):3134-3144. (PMID: 24021263) ISSN: 0167-4889

16. Rajpara N, Vinothkumar K, Mohanty P, Singh AK, Singh R, Sinha R, Nag D, Koley H, Kushwaha Bhardwaj A. Synergistic effect of various virulence factors leading to high toxicity of environmental V. cholerae non-O1/ non-O139 isolates lacking ctx gene : comparative study with clinical strains. PLoS One. 2013 Sep 23;8(9):e76200 (PMID: 24086707)

17. Singh R, Sripada L, Singh R* (2014) "Side effects of antibiotics during bacterial infections: Mitochondria, the main target in host cell Mitochondrion. 2014 May;16:50-4, ISSN: 1567-7249

18. Bhatelia K, Singh A, Tomar D, Singh K, Sripada L, Chagtoo M, Prajapati P, Singh R, Godbole MM, Singh R*. Antiviral signaling protein MITA acts as a tumor suppressor in breast cancer by regulating NF-κB induced cell death. Mol Basis of Diseases (BBA). 2014 Feb;1842(2):144-53. ISSN: 0925-4439 (PMID: 24239807)

19. Tomar D, Singh R*. TRIM13 regulates ubiquitination and turnover of NEMO to suppress TNF induced NF-κB activation. Cell Signal. 2014 Dec;26(12):2606-13. [Epub ahead of print] , ISSN: 0898-6568 (PMID: 25152375)

20. Bhatelia K, Singh K, Singh R*. TLRs: Linking inflammation and breast cancer. Cell Signal. 2014 Aug 3;26(11):2350-2357. doi: 10.1016/j.cellsig.2014.07.035. [Epub ahead of print] ISSN: 0898-6568 Review (PMID: 2509380)

21. Tomar D, Singh R. TRIM family proteins; Emerging class of RING E3 ligases as regulator of NF-κB pathway. Biol Cell. 2015 Jan;107(1):22-40 (PMID:25319221), 1768-322X

22. Prajapati P,  Sripada L, Singh K, Bhatelia K, Singh R, Singh R*. TNF-α regulates miRNA targeting mitochondrial complex-I and induces cell death in Dopaminergic cells. BBA - Molecular Basis of Disease. Biochim Biophys Acta. 2015 Mar;1852(3):451-61. (ISSN: 0925-4439)

23. Singh K, Poteryakhina A, Zheltukhin A, Bhatelia K, Prajapati P, Sripada L, Tomar D, Singh R, Singh AK, Chumakov PM, Singh R*. NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells. Mol Cell Res Biochim Biophys Acta. 2015 May;1853(5):1073-86 (PMID: 25639646) ISSN: 0167-4889

24. Tomar D, Prajapati P, Lavie J, Singh K, Lakshmi S, Bhatelia K, Roy M, Singh R, Bénard G, Singh R*. TRIM4; a novel mitochondrial interacting RING E3 ligase, sensitizes the cells to hydrogen peroxide (H2O2) induced cell death. Free Radic Biol Med. 2015 Oct 31;89:1036-1048.  (ISSN: 0891-5849)

25. Sripada L, Singh K, Lipatova AV, Singh A, Prajapati P, Tomar D, Bhatelia K, Roy M, Singh R, Godbole MM, Chumakov PM, Singh R*. hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells. J Mol Med (Berl). 2017 Jun;95(6):641-651. (PMID: 28220193) (ISSN: 0946-2716)

26. Bhatelia K, Singh K, Prajapati P, Sripada L, Roy M, Singh R*. MITA modulated autophagy flux promotes cell death in breast cancer cells. Cell Signal. 2017 Jul;35:73-83 (PMID: 28366813) (ISSN:0898-6568)

27. Singh AK, Patel P, Tomar D, Singh R, Sripada L, Prajapati P, Singh K, Singh R*. TBK1 regulates p62/sqstm1 mediated autophagic clearance of intracellular ubiquitinated Staphylococcus aureus in human epithelial cells. Transl Genet Genom 2017 May [Online First]

28. Prajapati P, Sripada L, Singh K, Roy M, Bhatelia K, Dalwadi P, Singh R*. Systemic Analysis of miRNAs in PD Stress Condition: miR-5701 modulates mitochondrial-lysosomal cross talk to regulate neuronal death. Mol Neurobiol. 2018 Jun;55(6):4689-4701 (ISSN: 0893-7648) (PMID: 28710704) 

29. Roy M, Tomar D, Singh K, Lakshmi S, Prajapati P, Bhatelia K, Gohel D, Singh R*. TRIM8 regulated autophagy modulates the level of cleaved Caspase-3 subunit to inhibit genotoxic stress induced cell death. Cell Signal. 2018 Aug;48:1-12. (PMID: 29678622), ISSN: 0898-6568

30. Singh K, Sripada L, Lipatova A, Roy M, Prajapati P, Gohel D, Bhatelia K, Chumakov PM, Singh R*. NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation. BBA Mol Cell Res. 2018 Jun 20;1865(9):1260-1276.  (PMID: 29932989) ISSN: 0167-4889

31. Pandeya A, Singh K, Patel C, Singh R, Patel C, Sawant K. (2019) Hyaluronic acid tethered pH-responsive alloy-drug nanoconjugates for multimodal therapy of glioblastoma: An intranasal route approach. Materials Science and Engineering: C 98, 419-436 (PMID: 30813043) ISSN: 0928-4931

32. Gohel D, Sripada L, Prajapati P, Singh K, Roy M, Kotadia D, Tassone F, Charlet-Berguerand N, Singh R*. FMRpolyG alters mitochondrial transcripts level and respiratory chain complex assembly in Fragile X associated tremor/ataxia syndrome [FXTAS]. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1379-1388 (PMID: 30771487) ISSN: ISSN: 0925-4439

33. Singh K, Roy M, Prajapati P, Sirpada L, Anastasia Lipatova, Mane M, Chumakov, Singh R*, NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells Biochimica et Biophysica Acta (BBA) - Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1460-1476 (ISSN: 0925-4439)

34. Prajapati P, Dalwadi P, Gohel D, Singh K, Sripada L, Bhatelia K, Joshi B, Roy M, Wang W, Springer JE, Singh R, Singh R* (2019) Enforced lysosomal biogenesis rescues  erythromycin‑ and clindamycin‑induced mitochondria-mediated cell death in human cells. Mol Cell Biochem. 2019 Nov;461(1-2):23-36 (PMID: 31309409) (ISSN: 0300-8177)

35. Abhijeet Pandey, Kritarth Singh, Suresh Subramanian, Aruna Korde, Rajesh Singh, Krutika Sawant (2020) Heterogeneous Surface Architectured pH Responsive Metal-Drug Nano-conjugates for Mitochondria Targeted Therapy of Glioblastomas: A Multimodal Intranasal Approach. Chemical Engineering Journal Volume 394, 15 August 2020, 124419 (ISSN: 1385-8947)

36. Gohel D, Berguerand NC, Tassone F, Singh R* (2020) The emerging molecular mechanisms for mitochondrial dysfunctions in FXTAS. Biochim Biophys Acta Mol Basis Dis. 2020 Aug 12;1866(12):165918 ((ISSN: 0925-4439)

37. Prajapati P, Gohel D, Shinde A, Roy M, Singh K, Singh R*.  (2020) TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death. Cellular Signaling 76, 109777 (PMID: 32918979) (ISSN: 0898-6568)

38. Gohel D, Singh R* (2021) Mitohormesis; Potential implications in neurodegenerative diseases. Mitochondrion, 2021, 50, 40-46 (ISSN: 1567-7249)

39. Currima F, Singh J, Shinde A, Gohel D, Roy M, Singh K, Shukla S, Mane M, Vasiyani H, Singh R* (2021) Exosome release is modulated by the mitochondrial-lysosomal crosstalk in Parkinson’s Disease stress conditions. Mol Neurobiology 58, 1819-1833 (ISSN: 0893-7648)

40. Goyani S, Roy M, Singh R* (2021) TRIM-NHL as RNA binding Ubiquitin E3 Ligase (RBUL): Implication in development and disease pathogenesis. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 5: 186 (7) 166066 ((ISSN:0925-4439)

41. Gohel D, Sripada L, Prajapati P, Singh K, Roy M, Kotadia D, Tassone F, Charlet-Berguerand N, Singh R*(2021) Expression of expanded FMR1-CGG repeats alters mitochondrial miRNAs and modulates mitochondrial functions and cell death in cellular model of FXTAS. Free Radical Biology and Medicine Mar;165:100-110 (ISSN:0891-5849)

42. Vasiyani H, Shinde A, Roy M, Mane M, Singh K, Singh J, Gohel D, Currim F, Vaidya K, Chhabria M, Singh R*. (2021) The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells. Apoptosis Jun;26(5-6):293-306 (ISSN: 1360-8185)

43. Shinde A, Jung H, Lee H, Singh K, Roy M, Gohel D, Kim HB, Mane M, Vasiyani1 H, Currim F, Seo YR, Yang S, Cho A, Yi EC, Singh R *(2021) TNF-α differentially modulates subunit levels of respiratory electron transport complexes of ER/PR +ve/−ve breast cancer cells to regulate mitochondrial complex activity and tumorigenic potential. Cancer and Metabolism Apr 29;9(1):19. doi: 10.1186/s40170-021-00254-9 (ISSN: 2049-3002)

44. Jani P, Suman S, Subramanian S, Korded A, Gohel D, Singh R, Sawant K, Development of mitochondrial targeted theranostic nanocarriers for treatment of gliomas. Journal of Drug Delivery Science and Technology Volume 64, August 2021, 102648. (ISSN: 1773-2247)

45. Roy M and Singh R.* TRIMs: selective recruitment at different steps of the NF-κB pathway-determinant of activation or resolution of inflammation. Cell Mol Life Sci 2021 Sep;78(17-18):6069-6086. (ISSN: 1420-682X)

46. Roy M, Singh K, Shinde A, Singh J, Mane M, Bedekar S, Tailor Y, Gohel D, Vasiyani H, Currim F, Singh R. TNF-α-induced E3 ligase, TRIM15 inhibits TNF-α-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1. Cellular Signalling. 2022;91:110210. (ISSN: 0898-6568)

47. Dhruv G and Singh R* (2022) Different platforms for mito-miRs in mitochondria: Emerging facets in regulation of mitochondrial functions. Mitochondrion 66, 67-73 (ISSN: 1567-7249)

48. Vasiyani H, Mane M, Rana K, Shinde A, Roy M, Singh J, Gohel D, Currim F, Srivastava R, Singh R (2022) DNA damage induces STING mediated IL-6-STAT3-PD-L1 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients. Apoptosis, 27, 961-78

49. Gohel D, Shukla S, Rajan WD, Wojtas B, Kaminska B, Singh R (2023) Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemi. Free Radic Biol Med. 2023 Apr;199:26-33.

50. Bora VR, Gohel D, Singh R, Patel BM. (2023) Evaluation of selected antidiabetics in cardiovascular complications associated with cancer cachexia. Mol Cell Biochem 478(4):807-820.

51. Vasiyani H, Wadhwa B, SinghR., (2023) Regulation of cGAS-STING signalling in cancer: Approach for combination therapy. Biochim Biophys Acta Rev Cancer 1878(3):188896.

52. Shukla S, Currim F, Singh J, Goyani S, Saranga MV, Shinde A, Mane M, Chandak N, Kishore S, Singh R* (2023) hsa-miR-320a mediated exosome release under PD stress conditions rescue mitochondrial ROS and cell death in the recipient neuronal and glial cells. The International Journal of Biochem Cell Bio : 162

53. Goyani S, Shinde A, Shukla S, Saranga MV, Currim F, Mane M, Singh J, Roy M, Gohel D, Chandak N, Vasiyani H, Singh R*. (2024) Enhanced translocation of TRIM32 to mitochondria sensitizes dopaminergic neuronal cells to apoptosis during stress conditions in Parkinson's disease. FEBS journal : 291(12):2636-2655

54. Shinde, A.; Tang, X.; Singh R.*; Brindley, D.N. (2024) Infliximab, a Monoclonal Antibody against TNF-α, Inhibits NF-κB Activation, Autotaxin Expression and Breast Cancer Metastasis to Lungs. Cancers, 16, 52

55. Shinde A, Chandak N, Singh J, Roy M, Mane M, Tang X, Vasiyani H, Currim F, Gohel D, Shukla S, Goyani S, Saranga MV, Brindley DN, Singh R*. (2024) TNF-α induced NF-κB mediated LYRM7 expression modulates the tumor growth and metastatic ability in breast cancer. Free Radic Biol Med :211:158-170

56. Currim F, Shukla S, Singh J, Gohel D, Mane M, Shinde A, Roy M, Goyani S, Vasiyani H, Chandran A, Rochet J, Cannon J, Singh R* (2024) Neuronal exosomal miRNAs modulate mitochondrial functions and cell death in bystander neuronal cells under Parkinson’s disease stress conditions. Neurotoxicology :101:102-116