Shatakshi shukla

Exosomes are Nano vesicles secreted from a wide range of biological fluids including blood, serum, saliva, tears and brain CNS. Recent studies have confirmed their relevance in mediating inter-cellular communication between different cell types of human body system. Exosomes have also implicated in the disease progression of various neurodegenerative disorders including Parkinson’s disease; however the molecular mechanisms involved in enhanced exosome release in PD stress is largely unknown. There are reports suggesting that modulation in autophagy, lysosome and mitochondrial functions may impact the exosome release process; however the interlinking between these processes is still a major area of research. My work elaborates on finding the clue for the network of miRNAs regulating the exosome release under Parkinson’s disease stress conditions. This involves looking for putative targets genes of lysosome, autophagy and mitochondrial pathway regulated by human miRNAs through bioinformatics analysis with further validation of the involvement of these processes in modulating the exosome release under PD stress. The findings through this study will be of great relevance to identify group of miRNAs having biomarker ability and therapeutic intervention.