Nisha Chandak

The recruitment of the circulatory monocytes at the tumor site is important determinant of the

inflammatory tumor microenvironment (TME) which may modulate the tumor progression and

metastasis. The tumor cells educate the infiltrate monocytes to differentiate into tumor

associated monocytes (TAMs). TAMs may have different TRIMs transcriptome profile compared

to normal monocytes. TRIMs are critical regulators of inflammation and tumorigenesis needs to

be further explored for its potential role in human breast tumorigenesis. This will be possible by

study of the peripheral blood, and thus will be a practical and less invasive strategy aimed at

individualizing treatment of breast cancer patients, early initiation of therapy, and improving

their outcomes. Thus, profiling of these TAMs can be used as biomarker for detection of breast

cancer.