Nisha Chandak
The recruitment of the circulatory monocytes at the tumor site is important determinant of the
inflammatory tumor microenvironment (TME) which may modulate the tumor progression and
metastasis. The tumor cells educate the infiltrate monocytes to differentiate into tumor
associated monocytes (TAMs). TAMs may have different TRIMs transcriptome profile compared
to normal monocytes. TRIMs are critical regulators of inflammation and tumorigenesis needs to
be further explored for its potential role in human breast tumorigenesis. This will be possible by
study of the peripheral blood, and thus will be a practical and less invasive strategy aimed at
individualizing treatment of breast cancer patients, early initiation of therapy, and improving
their outcomes. Thus, profiling of these TAMs can be used as biomarker for detection of breast
cancer.