Combo Antibiotics
For Chronic Lyme
March 3, 2017
Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi in vitro
Running title: Sulfa drugs and their combinations against B. burgdorferi persisters
Jie Feng, Shuo ZHANG, Wanliang Shi, YING ZHANG
doi: https://doi.org/10.1101/112607
QUOTE- "We found that sulfa drugs combined with other antibiotics were more active than their respective single drugs and that four-drug combinations were more active than three-drug combinations. Four drug combinations
dapsone+minocycline+cefuroxime+azithromycin
and
dapsone+minocycline+cefuroxime+rifampin
showed best activity against stationary phase B. burgdorferi in these sulfa drug combinations.
However, these 4-sulfa drug containing combinations still had considerably less activity against B. burgdorferi stationary phase cells than the
daptomycin+cefuroxime+doxycycline
used as a positive control which completely eradicated B. burgdorferi stationary phase cells."
More information on pdf file located here.