March 3, 2017

Activity of Sulfa Drugs and Their Combinations against Stationary Phase B. burgdorferi in vitro

Running title: Sulfa drugs and their combinations against B. burgdorferi persisters

Jie Feng, Shuo ZHANG, Wanliang Shi, YING ZHANG

doi: https://doi.org/10.1101/112607

QUOTE- "We found that sulfa drugs combined with other antibiotics were more active than their respective single drugs and that four-drug combinations were more active than three-drug combinations. Four drug combinations

dapsone+minocycline+cefuroxime+azithromycin

and

dapsone+minocycline+cefuroxime+rifampin

showed best activity against stationary phase B. burgdorferi in these sulfa drug combinations.

However, these 4-sulfa drug containing combinations still had considerably less activity against B. burgdorferi stationary phase cells than the

daptomycin+cefuroxime+doxycycline

used as a positive control which completely eradicated B. burgdorferi stationary phase cells."

More information on pdf file located here.

Link to Abstract Here