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Table of contents
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Medicine & Health
Glaucoma is an eye disease where the trabecular meshwork (spongy, porous tissue) located near the cornea is blocked, preventing excess liquid (aqueous humor) from draining out. As a result, the pressure inside the eye increases and impairs the optic nerve, which is responsible for sending visual input to the brain. As the leading cause of blindness, Glaucoma affects around 3 million Americans. Patients often experience loss of peripheral vision (tunnel vision), redness in the eye, and halos around light sources. Fortunately, there are many types of medications to either reduce the production of liquid, increase the outflow, or a combination...
Biochemistry
Using flow cytometry to analyze ADG-2 neutralization potential against Omicron B.1.1.529
One in 4 US residents have been infected with SARS-CoV-2, a virus which produced around 990k deaths due to the disease it causes, Covid-19. The severity of a Covid-19 infection can be mitigated when treated with monoclonal antibodies (mAbs). When mAbs bind to spike proteins located on the outside of the SARS-CoV-2 virus, its ability to infect human cells is neutralized. Unfortunately, among the many existing coronaviruses, each mAb can only treat a single strain. To address this issue, scientists have created a broadly neutralizing antibody (bnAb) named ADG-2 which can neutralize multiple coronavirus strains...
Computer Science
Multi-document summarization is the task of condensing a set of documents under the same topic to a subset that contains the most important information. This can be achieved using deep learning techniques within the subcategory of Natural Language Processing (NLP). NLP is the subcategory of artificial intelligence (AI) that refers to teaching computers how to process, understand, and produce text in a similar fashion to humans. Recently OpenAI, an artificial intelligence research laboratory, has developed an algorithm called the Generative Pre-trained Transformer Version 3 (GPT-3) whose main function is to generate text from a prompt...
Computer Science
Quantifying Political Bias in American News Articles with Natural Language Processing
In times of increasing political polarization, articles written in the news tend to become biased, making it more difficult to determine what is true and what is not. In fact, most Americans believe that 62% of news consumed from television and newspaper articles is biased, and they estimate that 80% of news from social media is biased. These biases skew facts in a certain direction to encourage people to make a certain decision. Human analysts require a lot of time to process a given article, meaning they cannot quantify the bias in many articles on the internet. To improve upon this, the goal of my proposed method...
Medicine & Health
The Effect of COVID-19 on the Development of Hypertension
The coronavirus disease 2019 (COVID-19) is a respiratory illness that has caused a global pandemic since early 2020 and led to the hospitalization and death of millions. COVID-19 has been shown to compromise the cardiovascular system, including the functions of the heart and blood vessels. Patients with cardiovascular disease, diabetes, and hypertension also suffer more severe symptoms from COVID-19. Although hypertension is associated with an increased risk of severe COVID-19 and higher mortality rate in these patients, few studies have looked into the impact of COVID-19 on the likelihood of developing hypertension...
Medicine & Health
Breast cancer (BC) is the most common type of cancer. In 2020, there were 684,996 deaths from BC. Inflammatory breast cancer (IBC) makes up only approximately 1-5% of all BC cases. IBC can occur when the cancerous cells infiltrate and block the lymph vessels in the breast. These lymph vessels typically drain fluids from the breasts, but in patients with IBC, they no longer can, leading to a buildup of fluids and, therefore, swelling and redness of the breasts. IBC has different symptoms and is not usually detectable in a mammogram, making it hard to diagnose until the third or fourth stage. Usually, doctors seek chemotherapy for their patients...
Behavioral Science
Although childhood outbursts may seem inconsequential, they are one of the most prominent warning signs of mood disorders later on in life. Mood disorders are the distortion of one’s emotional state and childhood outbursts are defined by a loss of emotional control, which would explain the correlation between the two as they both pertain to one’s emotional ability. Previous research has shown a direct correlation between childhood outbursts and depression in adulthood. However, no studies have investigated if there is a link between the severity of childhood outbursts and the severity of adulthood depression...
Cellular & Molecular Biology
Chronic wounds are wounds that fail to heal in an orderly set of stages and in a predictable amount of time the way most wounds do. In the U.S., 2% of people suffer from chronic wounds, and nearly 60% of these wounds are caused by infections. Unfortunately, wounds impair quality of life both physically and psychologically, while costing the medical system over $25 billion annually. The faster wound closure occurs, the less likely bacteria will infect the wound, fostering a need for the elucidation of potential biological agents that could accelerate regeneration. Previous studies have identified transforming growth factor-beta (TGF-β)...
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