Chemistry/Biochemistry
Placental Studies
Molly Flicker
Chemistry/Biochemistry
Molly Flicker
When mothers must mourn miscarriages and stillbirths it is devastating. In the United States, around 24,000 children are stillborn each year, a loss that occurs after 20 weeks after concption, and one in five pregnancies result in a miscarriage, which occurs before 20 weeks after conception. With stillbirth and miscarriages having such a high prevalence, many mothers are left without answers as to what caused their loss. Dr. Harvey Kliman, a clinical pathologist, and Bebe Thompson, a postgraduate researcher, conduct research at Yale University in New Haven that aims to provide mothers and families with answers about their pregnancy losses. Dr. Kliman’s previous research examined placental abnormalities across the three trimesters of pregnancies and their varying frequency. He further calculated the placental volume and how it was associated with adverse pregnancy outcomes. He found that smaller placentas were most often associated with stillbirths, and that the most common abnormality linked to pregnancy loss was indicative of genetic causes. This summer, as follow-up research, Dr. Kliman, Bebe Thompson, and I will be analyzing estimated placental volume data and examining if placental measurements have impacts on the likelihood of abnormalities. This research will be groundbreaking, for if certain placental measurements influence the likelihood of stillbirth and miscarriages, it could potentially lead to clinical interventions to save such fetuses and limit mothers' anxiety and grief.