Kinases are specific types of proteins that are able to active or deactivate other proteins within the cell. Since, proteins do all the work within the cell, kinases are extremely important. One pathway, out of many, that uses kinases is the MAPK, mitogen activated protein kinase pathway, which can help with cell death or cell growth; The outcome of the MAPK pathway depends on the stimulus. These kinases are used in wallerian degeneration, a form of axon degeneration. SARM1, a protein, plays a major role in this process of wallerian degeneration, mainly through the energy metabolism. This process of wallerian degeneration is jump started by the MAPK pathway. Another pathway involved with the MAPK pathway is ferroptosis. Ferroptosis is a specific type of cell death in which the mitochondria is affected to kill the cell through oxidants, unstable molecules, and cell death pathways, certain genes that are upregulated to kill the cell. Ferroptosis has several subpathways, the ones that will be relevant today are the MAPK, ROS, and iron metabolism subpathways. In the past, it has been found that the common pathway of ferroptosis is not related with wallerian degeneration, but the other pathways, such as the iron or ROS pathway have not been studied alongside ferroptosis. Therefore, I want to see which ferroptosis pathways, emphasizing the MAPK pathway, play a role in axon degeneration. Further, is it only small parts of the ferroptosis pathways that play a role in axon degeneration? To answer these questions, I will be using kinases to investigate. Essentially, I will find kinases, from online databases, the are related to axon degeneration, and then, through cell treatments, I will see if the kinase is related to ferroptosis. I will be using individual t tests, relationship tests, to see if I get statistically significant results. If I do find statistically significant results, then that can open up a wide array of new treatments for axon degeneration based on ferroptosis.