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66,763,863-66,950,461, I give you coordinates this time..
for the gene that you will have to mine..
It's a steroid hormone receptor on chromosome X..
that also has a trinucleotide repeat stretch..
Count the number of repeats as well..
Hope this Treasure Hunt is going swell..
Answer: Androgen Receptor, in the NCBI database its sequence has 15 CAG repeats.
Half of the population possess this gene..
Making them men and not mean..
As we are nearing the end of this first run..
Tell the initial ten amino acids and it's done..
Answer: Sry is the gene, the first ten amino acids that it codes for are: mqsyasamls
This non coding RNA lies upstream to the gene it regulates..
That gene product is required to keep X chromosome repressed..
Name the regulator ncRNA and tell the number of exons it possesses..
Even the regulated gene is an ncRNA, and so now you can guess..
Answer: Ftx, five prime to Xist. It has 7 exons.
This enzyme is present throughout the human body..
Letting our present foremost enemy gain entry..
Locate the sequence of this gene I meant..
Find and tell the strand on which it is present..
Answer: ACE2 is the enzyme which is used by SARS-COV2 to gain entry inside human cells. ACE2 is present on the reverse strand of X chromosome.
This is an example to highlight the fact that genes can be present on either strand of the chromosome.
Chromatin has to be opened up, as we tread ahead..
One protein that does this job lies on X's thread..
Without this humans can get a disease called Rett's..
Find the coordinates of this locus, no need to fret..
Answer: 154,021,573-154,137,103 (Taken from Ensembl)
There are multiple isoforms present, so your coordinates might be different from the ones given above!
This Japanese delicacy can kill you in a flash..
If the chef is not skilled enough to slash..
Find the length of its first chromosome to move forward..
That should be enough information for you, oh nerd!
Answer: 23,260,604 bp.
Fugu or puffer fish as some of answered correctly is the Japanese delicacy if not cooked properly can cause immediate death because of the presence of a neurotoxin called as tetrodotoxin.
Rita Levi-Montalcini led the way to this discovery..
One such factor lets you adapt and stay healthy..
The code to create which breaks most norms..
Count the number of transcripts it forms (in humans)..
Answer: The growth factor is NGF and its gene codes for one transcript.
Wriggly and transparent in form...
Fixed number of cells is its norm...
This locus let the 2006 Nobel Prize to be won...
Find the chromosome of that locus and it’s done!
Answer: Chromosome X (Location of let7 locus)
Let7 is a miRNA that was discovered by Craig Mello. He won the 2006 Nobel Prize with Andrew Fire in Physiology for the discovery of RNAi.
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