Team 16

Neurostimulation Device for the Treatment of Glioblastoma Multiforme

Team Members: Alexis Kiraly
Lauren Lossner
Grace Lowor
Cassie Riggs

Team Mentors: Bradley Greger, PhD - SBHSE
Benjamin Hendricks, MD - Barrow Neurological Institute
Sarah McBryan, MS - Barrow Neurological Institute
Dakota Graham, MS - Barrow Neurological Institute

YouTube Link: View the video link below before joining the zoom meeting

Zoom Link: https://asu.zoom.us/j/85454468398

Abstract

Glioblastoma multiforme (GBM) is a common and lethal nervous system malignancy with a median survival rate of 14-16 months. A noninvasive device that creates an alternating electric field uses electrodes on patients’ scalps and can extend life by approximately 4 months, but the electric field is weakened by dispersion into the low permittivity of the scalp and skull. Deep brain stimulation (DBS) with alternating electric field therapy is a proposed concept that places electrodes within neural tissue to produce stronger electric fields and extend patient survival. To test this hypothesis, a pseudo-CSF agarose solution was used in a first-round testing procedure. The electric field was measured and a predictable voltage output fall-off was observed. This experimental setup will allow us to optimize electric field magnitude, the number of electrodes needed, and the quantification of directionality of the electric field. Specifications critical to therapeutic efficacy are the magnitude and alternating frequency of stimulation. Virtual prototyping was utilized to optimize these specifications including electric field strength and taking into account the complex geometry of the tumor within the brain. Imaging software was used to create a 3D model of a tumor from an MRI scan of a patient with GBM. A 3D CAD model of the DBS electrode was used in conjunction with the tumor model to enable the possibility of analyzing the dispersion of electric field. These parallel prototyping efforts pave the way for clinicians to optimize and customize therapy for patients and increase the lifespan of those suffering from GBM.