Team 15

ANA Medical: ANAstoCoat

Team Members: Alexa Ng
Adrienne Parkinson
Natalie Santoro

Team Mentors: Vincent Pizziconi, PhD - SBHSE
Brent Vernon, PhD - SBHSE
David Row, MD - Dignity Health
Joseph Chung - Creighton University School of Medicine

YouTube Link: View the video link below before joining the zoom meeting

Zoom Link: https://asu.zoom.us/j/89613631597

Abstract

Anastomotic leak is one of the most detrimental complications that can occur after gastrointestinal surgery. It contributes to the high rates of mortality and morbidity associated with colorectal surgeries. Anastomoses are the sites where sections of the intestine are rejoined together after a portion of the bowel has been resected, usually by means of staples or sutures. The risk of bursting and subsequent leakage of luminal contents is high due to the fragility of these sites during healing. In studies with sample populations >300 patients, the incidence of postoperative anastomotic leak has consistently been reported as high as 13.5%. Wound healing in the gastrointestinal system is unique due to shear stress and the presence of anaerobic and aerobic bacteria. Shear stress is caused by colonic motility and mechanical disruption due to regular intestinal function. This is problematic because anastomosis healing requires a stable environment with minimal pressure and tension. Our solution, ANAstoCoat, is a hydrogel coating that is impregnated with insulin-like growth factor-1 (IGF-1), which is known to promote tissue healing, and designed to wrap around a colonic anastomosis. ANAstoCoat will remain at the anastomotic site for at least 7 days to help facilitate the healing process with the diffusion of IGF-1. Current solutions for anastomotic leaks include endoscopic vacuum therapies, negative pressure sponges, and surgical sealants. However, these methods have not been updated or proven effective in reducing complications. ANAstoCoat is designed to reduce the occurrence of anastomotic leak and associated mortality/morbidity rates by promoting healing with IGF-1. We expect ANAstoCoat to cost ~$400.