2025
Original Article
35. Mufidah, S.; Miyamae, Y.*; Fuchino, H.; Kawahara, N. (2025) A Cyclobutane-Bearing Phenylpropanoid from Kaempferia galanga L. with Nitric Oxide Inhibitory Activity, Natural Products and Bioprospecting, 15: 68.
34. Yang, Z.; Takahashi, T.; Hoshino, A.; Yamamoto, T.; Shigemori, H.; Miyamae, Y.* (2025) Biphasic Cellular Response Triggered by Tetrandrine-Mediated Dysfunction and Lysophagic Clearance of Lysosomes, ACS Chemical Biology, 20(7): 1660-1668. プレスリリース
2024
Original Article
33. Tozawa, Y.; Shinoda, S.; Sekiguchi, M.; Miyamae, Y.; Shigemori, H. (2024) Effect of meroterpenoids from Sargassum macrocarpum on the inhibition of amyloid aggregation associated with Alzheimer's disease and type 2 diabetes, Biological and Pharmaceutical Bulletin,47: 1961-1968.
32. Mufidah, S.; Atito, A.S.A.; Shigemori, H.; Miyamae, Y.* (2024) Decoration of GW9662 scaffold with a fragment hit via copper-catalyzed azide-alkyne cycloaddition reaction into peroxisome proliferator-activated receptor γ agonists, Tetrahedron Letters, 148: 155226.
31. Miyazawa, S.; Sakai, M.; Omae, Y.; Ogawa, Y.; Shigemori, H.; Miyamae, Y.* (2024) Anti-inflammatory effect of covalent PPARγ ligands that have a hybrid structure of GW9662 and a food-derived cinnamic acid derivative, Bioscience, Biotechnology, and Biochemistry, 88: 1136-1143.
30. Utsugi, Y.; Nishimura, K.; Yamanaka, S.; Nishino, K.; Kosako, H.; Sawasaki, T.; Shigemori, H.; Wandless, T.J.; Miyamae, Y.* (2024) Ubiquitin-Derived Fragment as a Peptide Linker for the Efficient Cleavage of a Target Protein from a Degron, ACS Chemical Biology, 19: 497-505.
29. Kishimoto, T.; Nishimura, K.; Morishita, K.; Fukuda, A.; Miyamae, Y.; Kumagai, Y.; Sumaru, K.; Nakanishi, M.; Hisatake, K.; Sano, M. (2024) An engineered ligand-responsive Csy4 endoribonuclease controls transgene expression from Sendai virus vectors, Journal of Biological Engineering, 18: 9.
Review, Book, etc.
(11) 宮前友策*、宮澤しなの、酒井美紗 (2024) 「リガンド結合ポケットの特性を利用した核内受容体アゴニストの創製」(2024) BIO Clinica, 39: 92-93.
2023
Original Article
28. Tanaka, T.; Fukushima, H.; Betkekar, V. V.; Ohmori, K.; Suzuki, K.; Miyamae, Y.; Shigemori, H. (2023) Effects of degree of polymerization of B-type procyanidins on amyloid aggregation, Heterocycles, 106: 1845-1854.
27. Suzuki, T..; Utsugi, Y.; Yamanaka, S.; Takahashi, H.; Sato, Y.; Sawasaki, T.; Miyamae, Y.* (2023) A strategy for orthogonal deubiquitination using a bump-and-hole aproach, RSC Chemical Biology, 4: 879-883.
2022
Original Article
26. Krama, A.; Tokura, N.; Isoda, H.; Shigemori, H.; Miyamae, Y.* (2022) Cyanidin 3-glucoside induces hepatocyte growth factor in normal dermal fibroblasts through the activation of β2-adrenergic receptor, ACS Omega, 7: 22889-22895.
Review, Book, etc.
(10) 宮前友策*、宮澤しなの、酒井美紗 (2022) 「リガンド結合ポケットの特性を利用した核内受容体アゴニストの創製」Medical Science Digest, 48: 552-553.
(9) 宮前友策* (2022) 「リガンド結合ポケットの特性を利用したフラグメント分子スクリーニングと核内受容体リガンドの創製」YAKUGAKU ZASSHI, 142: 1345-1351.
2021
Original Article
25. Hasegawa. T.; Osaka, M.; Miyamae, Y.; Nishino K.; Isoda, H.; Kawada, K.; Neffati, M.; Irie, K.; Nagao, M. (2021) Two types of PPARγ ligands identified in the extract of Artemisia campestris, Chemistry, 3: 647-657.
Review, Book, etc.
(8) Utsugi, Y.; Miyamae, Y*. (2021) Strategies for Post-Translational Control of Protein Expression and their Applications, Applied Sciences, 11(18): 8300. (Feature paper for Special Issue "Innovation of Biomolecular Sciences and Engineering)
(7) Miyamae, Y.* (2021) Insight into Dynamic Mechanism of Ligand Binding to Peroxisome Proliferator-Activated Receptor γ toward Potential Pharmacological Applications, Biological & Pharmaceutical Bulletin, 44: 1185-1195. (Current Topics, invited)
(6) 宇津木優樹、鈴木琢海、宮前友策* (2021)「小分子化合物による細胞内タンパク質の分解制御技術」バイオサイエンスとインダストリー、79: 200-204.
2020
Original Article
24. Miyamae, Y.; Chen, L.-C.; Utsugi, Y.; Farrants, H.; Wandless, T.J. (2020) A method for conditional regulation of protein stability in native or near-native form. Cell Chemical Biology, 27: 1573-1581.
23. Nishino, K.; Uesugi, H.; Hirasawa, A.; Ohtera, A.; Miyamae, Y.; Neffati, M.; Isoda, H.; Kambe, T.; Masuda, S.; Irie, K.; Nagao, M. (2020) Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFA1. Biochemical and Biophysical Research Communications, 522: 68-73.
2019
Original Article
22. Kurata, M.; Fujiwara, N.; Fujita, K.; Yamanaka, Y.; Seno, S.; Kobayashi, H.; Miyamae, Y.; Takahashi, N.; Shibuya, M.; Masuda, S. (2019) Food-derived compounds apigenin and luteolin modulate mRNA splicing of introns with weak splice sites. iScience, 22: 336-352.
21. Utsugi, Y.; Kobuchi, H.; Kawamura, Y.; Atito, A.S.A.; Nagao, M.; Isoda, H.; Miyamae, Y.* (2019) Importance of the proximity and orientation of ligand-linkage to the design of cinnamate-GW9662 hybrid compounds as covalent PPARγ agonists. Molecules, 24: 2019.
2017
Original Article
20. Kurata, M.; Murata, Y.; Momma, K.; Mursi, I.F.A.; Takahashi, M.; Miyamae, Y.; Kambe, T.; Nagao, M.; Narita, H.; Shibuya, Y.; Masuda, S. (2017) The isoflavone fraction from soybean presents the mRNA maturation inhibition activity. Bioscience, Biotechnology, and Biochemistry 81: 551-554.
19. Kurata, M.; Morimoto, M.; Kawamura, Y.; Mursi, I.F.A.; Momma, K.; Takahashi, M.; Miyamae, Y.; Kambe, T.; Nagao, M.; Narita, H.; Shibuya, Y.; Masuda, S. (2017) Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skelton. Biochemistry and Molecular Biology 2: 46-53.
2016
Original Article
18. Kidachi, E.; Kurisu, M.; Miyamae, Y.; Hanaki, M.; Murakami, K.; Irie, K.; Shigemori, H. (2016) Structure-Activity Relationship of Phenylpropanoid Glycosides on the Inhibition of Amyloid β Aggregation. Heterocycles 92: 1976-1982.
17. Fujimoto, S.; Tsuji, T.; Fujiwara, T.; Takeda, T.; Merriman, C.; Fukunaka, A.; Nishito, Y.; Fu, D.; Hoch, E.; Sekler, I.; Fukue, K.; Miyamae, Y.; Masuda, S.; Nagao, M.; Kambe, T. (2016) The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation. Biochemical Journal 473: 2611-2621.
16. Miyamae, Y.*; Nishito, Y.; Nakai, N.; Nagumo, Y.; Usui, T.; Masuda, S.; Kambe, T.; Nagao, M. (2016) Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line. Biochemical and Biophysical Research Communications 477: 40-46.
Review, Book, etc.
(5) 宮前友策、永尾雅哉 (2016)「核内受容体PPARγのユニークな特性と新奇リガンド開発への新展開」化学と生物 54: 791-793
2015
Original Article
15. Ohtera, A., Miyamae, Y.*, Yoshida, K., Maejima, K., Akita, T., Kakizuka, A., Irie, K., Masuda, S., Kambe, T., Nagao, M. (2015) Identification of a new type of covalent PPARγ agonist using a ligand-linking strategy, ACS Chemical Biology 10: 2794-2804.
14. Hashimoto, A., Ohkura, K., Takahashi, M., Kizu, K., Narita, H., Enomoto, S., Miyamae, Y., Masuda, S., Nagao, M., Irie, K., Ohigashi, H., Andrews, G. K., Kambe, T. (2015) Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting. Biochemical Journal 472: 183-193.
2014
Review, Book, etc.
(4) Nagao, M.; Ohtera, A.; Miyamae, Y.; Nakai, N.; Kawachi, A.; Kawada, K.; Han, J.; Isoda, H.; Neffati, M.; Akita, T.; Maejima, K.; Masuda, S.; Kambe, T.; Mori, N.; Irie, K. (2014) Identification of 6-Octadecynoic Acid, a Rare Acetylenic Fatty Acid, from a Methanol Extract of Marrubium vulgare L. As a Peroxisome Proliferator-Activated Receptor γ Agonist. Sustainable North African Society: Exploring Seeds and Resources for Innovation, Chapter 4, 49-58
2013
Original Article
13. Ohtera, A., Miyamae, Y., Nakai, N., Kawachi, A., Kawada, K., Han, J., Isoda, H., Neffati, M., Akita, T., Maejima, K., Masuda, S., Kambe, T., Mori, N., Irie, K., Nagao, M. (2013) Identification of 6-octadecynoic acid from methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist, Biochemical and Biophysical Research Communications 440: 204-209.
12. Fujimoto, S., Itsumura, N., Tsuji, T., Anan, Y., Tsuji, N., Ogra, Y., Kimura, T., Miyamae, Y., Masuda, S., Nagao, M., Kambe, T. (2013) Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of tissue non-specific alkaline phosphatase in the secretory pathway, PLoS ONE 8: e77445.
11. Kurisu, M., Nakasone, R., Miyamae, Y., Matsuura, D., Kanatani, H., Yano, S., Shigemori, H. (2013) Induction of hepatocyte growth factor production in human dermal fibroblasts by caffeic acid derivatives, Biological Pharmaceutical Bulletin 36: 2018-2021.
10. Nakasone, R., Kurisu, M., Onodera, M., Miyamae, Y., Matsuura, D., Kanatani, H., Yano, S., Shigemori, H. (2013) Promoting effects on hepatocyte growth factor production of daphnane diterpenoids from Daphne odora, Heterocycles 87: 1087-1092.
9. Kurisu, M., Miyamae, Y., Murakami, K., Han, J., Isoda, H., Irie, K., Shigemori, H. (2013) Acteoside, a phenylethanoid glucoside, inhibits amyloid β aggregation, Bioscience, Biotechnology, and Biochemistry 77: 1329-1332.
2012
Original Article
8. Miyamae, Y., Kurisu, M., Murakami, K., Han, J., Isoda, H., Irie, K., Shigemori, H. (2012) Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of 42-residue amyloid β protein, Bioorganic Medicinal Chemistry 20: 5844-5849.
7. Fujita, K., Okamura, M., Nishimoto, S., Kurihara, T., Momma, K., Miyamae, Y., Kambe, T., Nagao, M., Narita, H., Masuda, S. (2012) Establishment of the monitoring system which modulates the mRNA processing, Bioscience, Biotechnology, and Biochemistry 76: 1248-1251.
Review, Book, etc.
(3) 韓畯奎、宮前友策、繁森英幸、礒田博子 (2012)「カフェオイルキナ酸は神経細胞保護作用を持つ」化学と生物 50: 77-79
2011
Original Article
6. Miyamae, Y., Han, J., Sasaki, K., Terakawa, M., Isoda, H., Shigemori, H. (2011) 3,4,5-tri-O-caffeoylquinic acid inhibits amyloid β-mediated cellular toxicity on SH-SY5Y cells through the upregulation of PGAM1 and G3PDH, Cytotechnology 63: 191-200.
5. Miyamae, Y., Kurisu, M., Han, J., Isoda, H., Shigemori, H. (2011) Structure-activity relationship of caffeoylquinic acids on the accelerating activity on ATP production, Chemical Pharmaceutical Bulletin 59: 502-507.
4. Ogawa, A., Miyamae, Y., Honma, A., Koyama, T., Yazawa, K., Shigemori, H. (2011) Pycnalin, a new α-glucosidase inhibitor from Acer pycnanthum, Chemical Pharmaceutical Bulletin 59: 672-675.
2010
Original Article
3. Han, J., Miyamae, Y., Shigemori, H., Isoda, H. (2010) Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and SAMP8 mice through the up-regulation of PGK1, Neuroscience 169: 1039-1045.
2009
Original Article
2. Miyamae, Y., Villareal, O. M., Abdrabbah, B. M., Isoda, H, Shigemori, H. (2009) Hirseins A and B, daphnane diterpenoids from Thymelaea hirsuta that inhibit melanogenesis on B16 melanoma cells, Journal of Natural Products 72: 938-941.
Review, Book, etc.
(2) 宮前友策, 「生合成酵素遺伝子導入によるニチニチソウアルカロイドの変換」ファルマシア トピックス、 2009年10月号
(1) Matsuyama, K.; Miyamae, Y.; Sekii, Y.; Kchouk, M.; Morio, T.; Shigemori, H.; Isoda, H. Effect of Mediterranean medicinal plant extracts on melanogenesis regulation, (2009) Journal of Arid Land Studies, 19: 387-390.
2007
Original Article
1.Kawano, M., Matsuyama, K., Miyamae, Y., Shinmoto, H., Kchouk, M., Morio, T., Shigemori, H., Isoda, H. (2007) Antimelanogenesis effect of Tunisian herb Thymelaea hirsute extract on B16 melanoma cells, Experimental Dermatology 16: 977-984.