We will work with you to come up with themes that excite you. Keywords: Brain, Neuron, Glial cells, Cell Biology, Physiology, Pathology, Molecular Biology, Learning and Memory, Microscopy, Membrane, Single- Molecule Analysis, Calcium Signaling, Alzheimer's Disease, Technology Development Research materials: Primary culture neurons from mice and rats, Cell culture, iPS Cells, Quantum dots, Antibodies, DNA, Fluorescent probes Methodology: Single-molecule imaging, intracellular signal imaging, molecular biology, image analysis, cell biology <Examples of Research Themes> Research to understand how the brain works and the mechanisms that cause neurodegenerative diseases through molecular dynamics ○Analysis of synapses in model cells of neurological diseases (multiple models of Alzheimer's disease, autism, schizophrenia, ALS, epilepsy) ○Analysis of abnormal membrane molecular dynamics in human patient iPS cells (ALS, schizophrenia, etc.) ○Effect of serum derived from patients with NMDA receptor antibody encephalopathy on membrane molecular dynamics ○Effects of anesthetics on membrane molecular dynamics ○Activity imaging of calcium signaling downstream molecules involved in memory and learning ○Study of the actions of neurotrophic factors and synaptic organizers ○Visualization of calcium signaling nanodomains
Development of new technologies for the diagnosis of neurological diseases and life sciences ○Creation and validation of degenerate tau visualization probes ○Establishment of in vivo imaging system of degenerate tau degeneration ○Establishment of a single-molecule imaging method using nucleic acid aptamers ○Establishment of a high-throughput single-molecule dynamics data analysis method using machine learning ○Cell personality from membrane molecular dynamics ○ Development of techniques to manipulate tau dynamics