Research theme for students
(Bannai Lab)
We will work with you to come up with themes that excite you.
Keywords: Brain, Neuron, Glial cells, Cell Biology, Physiology, Pathology, Molecular Biology, Learning and Memory, Microscopy, Membrane, Single- Molecule Analysis, Calcium Signaling, Alzheimer's Disease, Technology Development
Research materials: Primary culture neurons from mice and rats, Cell culture, iPS Cells, Quantum dots, Antibodies, DNA, Fluorescent probes
Methodology: Single-molecule imaging, intracellular signal imaging, molecular biology, image analysis, cell biology
<Examples of Research Themes>
Research to understand how the brain works and the mechanisms that cause neurodegenerative diseases through molecular dynamics
○Analysis of synapses in model cells of neurological diseases (multiple models of Alzheimer's disease, autism, schizophrenia, ALS, epilepsy)
○Analysis of abnormal membrane molecular dynamics in human patient iPS cells (ALS, schizophrenia, etc.)
○Effect of serum derived from patients with NMDA receptor antibody encephalopathy on membrane molecular dynamics
○Effects of anesthetics on membrane molecular dynamics
○Activity imaging of calcium signaling downstream molecules involved in memory and learning
○Study of the actions of neurotrophic factors and synaptic organizers
○Visualization of calcium signaling nanodomains
We will work with you to come up with themes that excite you.
Keywords: Brain, Neuron, Glial cells, Cell Biology, Physiology, Pathology, Molecular Biology, Learning and Memory, Microscopy, Membrane, Single- Molecule Analysis, Calcium Signaling, Alzheimer's Disease, Technology Development
Research materials: Primary culture neurons from mice and rats, Cell culture, iPS Cells, Quantum dots, Antibodies, DNA, Fluorescent probes
Methodology: Single-molecule imaging, intracellular signal imaging, molecular biology, image analysis, cell biology
<Examples of Research Themes>
Research to understand how the brain works and the mechanisms that cause neurodegenerative diseases through molecular dynamics
○Analysis of synapses in model cells of neurological diseases (multiple models of Alzheimer's disease, autism, schizophrenia, ALS, epilepsy)
○Analysis of abnormal membrane molecular dynamics in human patient iPS cells (ALS, schizophrenia, etc.)
○Effect of serum derived from patients with NMDA receptor antibody encephalopathy on membrane molecular dynamics
○Effects of anesthetics on membrane molecular dynamics
○Activity imaging of calcium signaling downstream molecules involved in memory and learning
○Study of the actions of neurotrophic factors and synaptic organizers
○Visualization of calcium signaling nanodomains
Development of new technologies for the diagnosis of neurological diseases and life sciences
○Creation and validation of degenerate tau visualization probes
○Establishment of in vivo imaging system of degenerate tau degeneration
○Establishment of a single-molecule imaging method using nucleic acid aptamers
○Establishment of a high-throughput single-molecule dynamics data analysis method using machine learning
○Cell personality from membrane molecular dynamics
○ Development of techniques to manipulate tau dynamics
Development of new technologies for the diagnosis of neurological diseases and life sciences
○Creation and validation of degenerate tau visualization probes
○Establishment of in vivo imaging system of degenerate tau degeneration
○Establishment of a single-molecule imaging method using nucleic acid aptamers
○Establishment of a high-throughput single-molecule dynamics data analysis method using machine learning
○Cell personality from membrane molecular dynamics
○ Development of techniques to manipulate tau dynamics