Embedded Files
The Basics
The Basics
Bamalan, O. A., Moore, M. J., & Khalili, Y. A. (2023, July 30). Physiology, serotonin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK545168/
Mking. (2024, March 28). Biochemistry of nerve transmission. The Medical Biochemistry Page. https://themedicalbiochemistrypage.org/biochemistry-of-nerve-transmission/#5ht
Whitaker‐Azmitia, P. M. (1999). The Discovery of Serotonin and its Role in Neuroscience. Neuropsychopharmacology, 21(2), 2S-8S. https://doi.org/10.1016/s0893-133x(99)00031-7
⬅️ serotonergic neurons and their connections within the brain
Charnay, Y., & Léger, L. (2010). Brain serotonergic circuitries. Dialogues in Clinical Neuroscience, 12(4), 471–487. https://doi.org/10.31887/dcns.2010.12.4/ycharnay
Berger, M., Gray, J. A., & Roth, B. L. (2009). The expanded Biology of Serotonin. Annual Review of Medicine (Print), 60(1), 355–366. https://doi.org/10.1146/annurev.med.60.042307.110802
Serotonin in the GI Tract
Serotonin in the GI Tract
⬅️ a. different cells involved in serotonin signaling in the gut. b. expression of serotonin in the colon
c. expression of the serotonin transporter in the rectum
Mawe, G. M., & Hoffman, J. M. (2013). Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets. Nature Reviews. Gastroenterology & Hepatology (Print), 10(8), 473–486. https://doi.org/10.1038/nrgastro.2013.105
Spencer, N. J., & Hu, H. (2020). Enteric nervous system: sensory transduction, neural circuits and gastrointestinal motility. Nature Reviews. Gastroenterology & Hepatology (Print), 17(6), 338–351. https://doi.org/10.1038/s41575-020-0271-2
Wang, Y. B., De Lartigue, G., & Page, A. J. (2020). Dissecting the role of subtypes of gastrointestinal vagal afferents. Frontiers in Physiology, 11. https://doi.org/10.3389/fphys.2020.00643
⬅️ vagal circuits involved in nausea/vomiting regulation
Babic, T., & Browning, K. N. (2014). The role of vagal neurocircuits in the regulation of nausea and vomiting. European Journal of Pharmacology, 722, 38–47. https://doi.org/10.1016/j.ejphar.2013.08.047
Breit, S., Kupferberg, A., Rogler, G., & Hasler, G. (2018). Vagus nerve as modulator of the Brain–Gut axis in psychiatric and inflammatory disorders. Frontiers in Psychiatry, 9. https://doi.org/10.3389/fpsyt.2018.00044
⬇️EC cells and their connections with other cells and the ENS.
Tao, E., Zhu, Z., Hu, C., Gao, L., Chen, B., Guo, R., Fang, M., & Jiang, M. (2022). Potential roles of enterochromaffin cells in early life Stress-Induced Irritable Bowel Syndrome. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.837166
⬅️ depiction of area postrema used in presentation
McGinnis, Woody & Audhya, Tapan & Edelson, Stephen. (2013). Proposed Toxic and Hypoxic Impairment of a Brainstem Locus in Autism. International journal of environmental research and public health. 10. 6955-7000. 10.3390/ijerph10126955.
Sterling, M. (2014, July 20). The second brain | our enteric nervous system | MFIT. https://www.mfi-therapy.com/the-second-brain-our-enteric-nervous-system/
Zhong, W., Shahbaz, O., Teskey, G., Beever, A., Kachour, N., Venketaraman, V., & Darmani, N. A. (2021). Mechanisms of nausea and vomiting: Current knowledge and recent advances in intracellular emetic signaling systems. International Journal of Molecular Sciences (Online), 22(11), 5797. https://doi.org/10.3390/ijms22115797
Fung, C., & Vanden Berghe, P. (2020). Functional circuits and signal processing in the enteric nervous system. Cellular and Molecular Life Sciences (Print), 77(22), 4505–4522. https://doi.org/10.1007/s00018-020-03543-6
Serotonin Receptors
Serotonin Receptors
⬆️ table of the serotonin receptors
Frazer, A., & Hensler, J. G. (1999). Serotonin receptors. Basic Neurochemistry - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK28234/
Garcia-García, Á. L., Newman‐Tancredi, A., & Leonardo, E. D. (2013). P5-HT1A receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function. Psychopharmacology/Psychopharmacologia, 231(4), 623–636. https://doi.org/10.1007/s00213-013-3389-x
Banerjee, P., Mehta, M., & Kanjilal, B. (2007). The 5-HT1A receptor: a signaling hub linked to emotional balance. Serotonin Receptors in Neurobiology - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK5212/
Altieri, S. C., Garcia-García, Á. L., Leonardo, E. D., & Andrews, A. M. (2012). Rethinking 5-HT1A receptors: Emerging modes of inhibitory feedback of Relevance to Emotion-Related Behavior. ACS Chemical Neuroscience, 4(1), 72–83. https://doi.org/10.1021/cn3002174
Glikmann‐Johnston, Y., Saling, M. M., Reutens, D. C., & Stout, J. C. (2015). Hippocampal 5-HT1A receptor and spatial learning and memory. Frontiers in Pharmacology, 6. https://doi.org/10.3389/fphar.2015.00289
Zhang, G., & Stackman, R. W. (2015). The role of serotonin 5-HT2A receptors in memory and cognition. Frontiers in Pharmacology, 6. https://doi.org/10.3389/fphar.2015.00225
Werry, T. D., Loiacono, R., Sexton, P. M., & Christopoulos, A. (2008). RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function. Pharmacology & Therapeutics, 119(1), 7–23. https://doi.org/10.1016/j.pharmthera.2008.03.012
Heisler, L. K., Pronchuk, N., Nonogaki, K., Zhou, L., Raber, J., Tung, L. Y., Yeo, G. S., O’Rahilly, S., Colmers, W. F., Elmquist, J. K., & Tecott, L. H. (2007). Serotonin activates the Hypothalamic-Pituitary-Adrenal axis via serotonin 2C receptor stimulation. the Journal of Neuroscience/the Journal of Neuroscience, 27(26), 6956–6964. https://doi.org/10.1523/jneurosci.2584-06.2007
Thompson, A., & Lummis, S. C. R. (2006). 5-HT3 receptors. Current Pharmaceutical Design (Print), 12(28), 3615–3630. https://doi.org/10.2174/138161206778522029
Navari, R. M. (2015). 5-HT3 receptors as important mediators of nausea and vomiting due to chemotherapy. Biochimica Et Biophysica Acta (BBA) - Biomembranes, 1848(10), 2738–2746. https://doi.org/10.1016/j.bbamem.2015.03.020
Thompson, A., & Lummis, S. C. R. (2006). 5-HT3 receptors. Current Pharmaceutical Design (Print), 12(28), 3615–3630. https://doi.org/10.2174/138161206778522029
CNS Functions
CNS Functions
⬅️ depiction of the limbic system, which mediates emotion and memory behaviors, and is under serotonergic influence.
Madua, Aurélie. (2022). Teaching English to the rythm of the brain. Journal of Neuroeducation. 3. 10.1344/joned.v3i1.39456.
Buhot, M., Martin, S., & Ségu, L. (2000). Role of serotonin in memory impairment. Annals of Medicine, 32(3), 210–221. https://doi.org/10.3109/07853890008998828
Der-Avakian, A., & Markou, A. (2012). The neurobiology of anhedonia and other reward-related deficits. Trends in Neurosciences, 35(1), 68–77. https://doi.org/10.1016/j.tins.2011.11.005
⬅️ serotonin and acetylcholine innervation in the visual system.
Shimegi, S., Kimura, A., Sato, A., Aoyama, C., Mizuyama, R., Tsunoda, K., Ueda, F., Araki, S., Goya, R., & Sato, H. (2016). Cholinergic and serotonergic modulation of visual information processing in monkey V1. Journal of Physiology (Paris), 110(1–2), 44–51. https://doi.org/10.1016/j.jphysparis.2016.09.001
Drugs and Pathologies
Drugs and Pathologies
Shimegi, S., Kimura, A., Sato, A., Aoyama, C., Mizuyama, R., Tsunoda, K., Ueda, F., Araki, S., Goya, R., & Sato, H. (2016). Cholinergic and serotonergic modulation of visual information processing in monkey V1. Journal of Physiology (Paris), 110(1–2), 44–51. https://doi.org/10.1016/j.jphysparis.2016.09.001
Kalant, H. (2001, October 10). The pharmacology and toxicology of “ecstasy” (MDMA) and related drugs. PubMed Central (PMC). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC81503/
Liechti, M. E. (2017). Modern Clinical research on LSD. Neuropsychopharmacology, 42(11), 2114–2127. https://doi.org/10.1038/npp.2017.86
Dobbertin, M., Blair, K. S., Carollo, E., Blair, J., Dominguez, A., & Bajaj, S. (2023). Neuroimaging alterations of the suicidal brain and its relevance to practice: an updated review of MRI studies. Frontiers in Psychiatry, 14. https://doi.org/10.3389/fpsyt.2023.1083244
Pandey, G. N., Dwivedi, Y. K., Rizavi, H. S., Ren, X., Pandey, S. C., Pesold, C., Roberts, R. C., Conley, R. R., & Tamminga, C. A. (2002). Higher expression of serotonin 5-HT2AReceptors in the postmortem brains of teenage suicide victims. the American Journal of Psychiatry, 159(3), 419–429. https://doi.org/10.1176/appi.ajp.159.3.419
Albert, P. R., Vahid-Ansari, F., & Luckhart, C. (2014). Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Frontiers in Behavioral Neuroscience, 8. https://doi.org/10.3389/fnbeh.2014.00199
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