Embedded Files
Thank you to these guys for making the quality
cartoon figures I used in this lecture. 👉
Basic genetics
Basic genetics
In-depth descriptions from my favorite textbook helped me present a foundation on which to build an explanation of epigenetics.
Chromosomes and Chromatin Structure
Alberts, B., Johnson, A. D., Lewis, J., Raff, M., Roberts, K., & Wipf, P. (2015). DNA, chromosomes, and genomes. In Molecular biology of the cell (6th ed., pp. 179–220). https://doi.org/10.1201/9780203833445
Genomic Imprinting
This image from the textbook made me finally understand this weird concept.
Alberts, B., Johnson, A. D., Lewis, J., Raff, M., Roberts, K., & Wipf, P. (2015). Control of gene expression. In Molecular biology of the cell (6th ed., p. 408). https://doi.org/10.1201/9780203833445
Epigenetic Mechanisms
Epigenetic Mechanisms
A basic introduction to the concepts of epigenetics.
Aboud, N. M. A. (2023, August 14). Genetics, epigenetic mechanism. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK532999/
Gilbert, N. (2003). Formation of facultative heterochromatin in the absence of HP1. The EMBO Journal, 22(20), 5540–5550. https://doi.org/10.1093/emboj/cdg520
Histone Modifications
Grayson, Dennis & Kundakovic, Marija & Sharma, Rajiv. (2009). Is There a Future for Histone Deacetylase Inhibitors in the Pharmacotherapy of Psychiatric Disorders?. Molecular pharmacology. 77. 126-35. 10.1124/mol.109.061333.
Wei, S., Li, C., Yin, Z., Wen, J., Meng, H., Xue, L., & Wang, J. (2018). Histone methylation in DNA repair and clinical practice: new findings during the past 5-years. Journal of Cancer, 9(12), 2072–2081. https://doi.org/10.7150/jca.23427
Mariño-Ramírez, L., Kann, M. G., Shoemaker, B. A., & Landsman, D. (2005). Histone structure and nucleosome stability. Expert Review of Proteomics, 2(5), 719–729. https://doi.org/10.1586/14789450.2.5.719
Smith, B. C., & Denu, J. M. (2009). Chemical mechanisms of histone lysine and arginine modifications. Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1789(1), 45–57. https://doi.org/10.1016/j.bbagrm.2008.06.005
Bae, S., & Lesch, B. J. (2020). H3K4ME1 distribution predicts transcription state and poising at promoters. Frontiers in Cell and Developmental Biology, 8. https://doi.org/10.3389/fcell.2020.00289
EpiGenie. (2015, August 18). Histone H3K9 Review. EpiGenie | Epigenetics, Stem Cell, and Synthetic Biology News. https://epigenie.com/key-epigenetic-players/histone-proteins-and-modifications/histone-h3k9/
In the DNA Repair Response
In the DNA Repair Response
Van, H. T., & Santos, M. A. (2018). Histone modifications and the DNA double-strand break response. Cell Cycle, 17(21–22), 2399–2410. https://doi.org/10.1080/15384101.2018.1542899
Kang, R., Żelazowski, M. J., & Cole, F. (2018). Missing the mark: PRDM9-Dependent methylation is required for meiotic DSB targeting. Molecular Cell, 69(5), 725–727. https://doi.org/10.1016/j.molcel.2018.02.021
Jeon H-Y, Hussain A, Qi J. Role of H3K9 demethylases in DNA double-strand break repair. J Cancer Biol 2020; 1(1): 10-15.
Savage, K. I., & Harkin, D. P. (2014). BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability. FEBS Journal, 282(4), 630–646. https://doi.org/10.1111/febs.13150
Cannan, W. J., & Pederson, D. S. (2015). Mechanisms and Consequences of Double-Strand DNA break formation in Chromatin. Journal of Cellular Physiology, 231(1), 3–14. https://doi.org/10.1002/jcp.25048
Schäffer, E., Beerman, I., De Cabo, R., & Brosh, R. M. (2023). Frontiers in aging special issue: DNA repair and interventions in aging perspective on “loss of epigenetic information as a cause of mammalian aging.” Frontiers in Aging, 4. https://doi.org/10.3389/fragi.2023.1199596
DNA Methylation
Mainly cytosine gets methylated in DNA.
Unoki, M. (2020). Recent Insights into the Mechanisms ofDe Novoand Maintenance of DNA Methylation in Mammals. In IntechOpen eBooks. https://doi.org/10.5772/intechopen.89238
Koh, W. K., Celik, H., Tao, J., Fairchild, J., Kukhar, O., Zhang, C., Gontarz, P., & Challen, G. A. (2021). DNMT3A Regulates Hematopoietic Stem Cell Function Via DNA Methylation-Independent Functions. Blood, 138(Supplement 1), 24. https://doi.org/10.1182/blood-2021-153759
Epigenetic Functions
Epigenetic Functions
Development and Gametogenesis
Fantastic image made by Mariuswalter
Klatt, E. C., MD. (n.d.). Normal histology. Edward C. Klatt MD. https://webpath.med.utah.edu/HISTHTML/NORMAL/NORM172.html
Roger. (2021, May 24). Sertoli Cell Only Syndrome. Quotes Trending. https://quotestrendingnl.blogspot.com/2021/05/sertoli-cell-only-syndrome.html
Kiefer, J. C. (2007). Epigenetics in development. Developmental Dynamics, 236(4), 1144–1156. https://doi.org/10.1002/dvdy.21094
Kuzdere, T., Flury, V., Schalch, T., Iešmantavičius, V., Heß, D., & Bühler, M. (2022). Differential phosphorylation of Clr4 SUV39H by Cdk1 accompanies a histone H3 methylation switch that is essential for gametogenesis. EMBO Reports, 24(1). https://doi.org/10.15252/embr.202255928
Gopinathan, G., & Diekwisch, T. G. (2022). Epigenetics and early development. Journal of Developmental Biology, 10(2), 26. https://doi.org/10.3390/jdb10020026
Li, Y., & Sasaki, H. (2011). Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming. Cell Research, 21(3), 466–473. https://doi.org/10.1038/cr.2011.15
Plasschaert, R. N., & Bartolomei, M. S. (2014). Genomic imprinting in development, growth, behavior and stem cells. Development, 141(9), 1805–1813. https://doi.org/10.1242/dev.101428
Kawasaki, Y., Lee, J., Matsuzawa, A., Kohda, T., Kaneko-Ishino, T., & Ishino, F. (2014). Active DNA demethylation is required for complete imprint erasure in primordial germ cells. Scientific Reports, 4(1). https://doi.org/10.1038/srep03658
Bajrami, E., & Спироски, М. (2016). Genomic Imprinting. Open Access Macedonian Journal of Medical Sciences, 4(1), 181–184. https://doi.org/10.3889/oamjms.2016.028
X-inactivation
Panning, B. (2008). X-chromosome inactivation: the molecular basis of silencing. Journal of Biology, 7(8), 30. https://doi.org/10.1186/jbiol95
Lu, Z., Carter, A. C., & Chang, H. Y. (2017). Mechanistic insights in X-chromosome inactivation. Philosophical Transactions of the Royal Society B, 372(1733), 20160356. https://doi.org/10.1098/rstb.2016.0356
ibiology. (2019, September 27). X Chromosome Inactivation • iBiology. iBiology. https://www.ibiology.org/development-and-stem-cells/x-chromosome-inactivation/
Willard, H. F. (1996). X chromosome inactivation, XIST, and pursuit of the X-Inactivation Center. Cell, 86(1), 5–7. https://doi.org/10.1016/s0092-8674(00)80071-9
Page updated
Google Sites
Report abuse