How NOT

To Do A Study

Community of Health Sciences Study, Sweden- In this study we required not only a positive result on a routine ELISA, but also verification with a second ELISA before a case was included as Lyme disease.

Community of Health Sciences Study, Sweden- Patients with arthralgia, myalgia, and the fibromyalgia syndrome alone were excluded.

Community of Health Sciences Study, Sweden- Headache, fatigue, paresthesia, or mild neck stiffness alone was not accepted as evidence of neurologic involvement.

Community of Health Sciences Study, Sweden- Palpitations, bradycardia, bundle-branch block, and myocarditis as single symptoms were not accepted.

Community of Health Sciences Study, Sweden- Cases with negative Western blots were excluded.

Community of Health Sciences Study, Sweden- Twenty-seven of 85 patients had negative Western blot tests and were therefore classified as not having Lyme disease.

Community of Health Sciences Study, Sweden- A lumbar puncture was performed in 284 of 369 patients with neurologic symptoms.

Community of Health Sciences Study, Sweden- Patients with increased numbers of lymphocytes had no detectable antibodies to B. burgdorferi in cerebrospinal fluid or in serum and were therefore classified as not having Lyme disease.

Community of Health Sciences Study, Sweden- Results/Conclusions- Most of the patients had benign symptoms.

Turku University Central Hospital, Finland- Only patients with culture- or PCR-proven disease were enrolled in the study.

Turku University Central Hospital, Finland- Avoid patients with post-Lyme syndrome (1993).