Dr. Anil Tiwari

SCIENTIST- D

RAMALINGAM FELLOW

Stem Cell Department

Dr. Shroff's Charity Eye Hospital, Daryaganj

SOCIAL

https://www.linkedin.com/in/anil-tiwari-8b2557a1/

https://www.researchgate.net/profile/Anil-Tiwari-4

https://scholar.google.com/citations?hl=en&user=ADy2FnwAAAAJ

ABOUT

Dr. Anil Tiwari does an extensive research in Stem cells and bioengineering, Molecular Biology, Developmental and Cell Biology and biomaterial. His research focus is on understanding the ocular surface pathologies using cutting edge technologies and integrating with stem cells and bioengineering strategies to design therapeutic interventions. From his Ph.D., he is pursuing the field of ophthalmology and have gained deep knowledge in the clinical aspect of the field. Right now he has an expertise in Ocular Surface disease and other ocular fibrotic diseases. Currently he is working on understanding various ocular surface disease and wound healing model.

My focus areas of research are:

1) Use of stem cells and stem cells in a) ocular surface reconstruction and regeneration, b) Glaucoma and c) oculoplasty

2) Understanding the cellular and molecular mechanism of SLET in an ocular surface regeneration

2) Ocular immunology a) inflammatory eye diseases, b) Allergic eye diseases

2) Role of KLF4 in Corneal epithelial homeostasis

3) Understanding the cellular and molecular aspects of Keratoconus

5) Understanding the host-pathogen interaction in keratitis and the role of epigenetics

6) Bioengineered biomaterials and the corneal regeneration

7) Cellular and molecular aspects in PBK

8) Role of patient derive vitreous in the pathogenesis of proliferative vitreoretinopathy (PVR)

9) Ocular oncology

selected publications

Isothiocyanates: a class of bioactive metabolites with chemopreventive potential

G Kumar, HS Tuli, S Mittal, JK Shandilya, A Tiwari, SS Sandhu

Tumor Biology 36 (6), 4005-4016

2015

KLF4 plays an essential role in corneal epithelial homeostasis by promoting epithelial cell fate and suppressing epithelial–mesenchymal transition

A Tiwari, CL Loughner, S Swamynathan, SK Swamynathan

Investigative ophthalmology & visual science 58 (5), 2785-2795

2017

Targeting the fibronectin type III repeats in tenascin-C inhibits epithelial–mesenchymal transition in the context of posterior capsular opacification

A Tiwari, J Ram, M Luthra-Guptasarma

Investigative ophthalmology & visual science 56 (1), 272-283

2015

Biofilm-associated indole acetic acid producing bacteria and their impact in the proliferation of biofilm mats in solar salterns

S Kerkar, L Raiker, A Tiwari, S Mayilraj, S Dastager

Biologia 67 (3), 454-460

2012

Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin

M Sharma, A Tiwari, S Sharma, P Bhoria, V Gupta, A Gupta, ...

PLoS One 8 (7), e69343

2013

Control of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody

A Tiwari, R Kumar, J Ram, M Sharma, M Luthra-Guptasarma

Scientific reports 6 (1), 1-13

2016

The secreted Ly-6/uPAR related protein-1 (SLURP1) stabilizes epithelial cell junctions and suppresses TNF-α-induced cytokine production

G Campbell, S Swamynathan, A Tiwari, SK Swamynathan

Biochemical and biophysical research communications 517 (4), 729-734

2019

KLF4 regulates corneal epithelial cell cycle progression by suppressing canonical TGF-β signaling and upregulating CDK inhibitors P16 and P27

A Tiwari, S Swamynathan, N Alexander, J Gnalian, S Tian, ...

Investigative ophthalmology & visual science 60 (2), 731-740

2019

Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C: Targeting fibronectin type III …

BB Mehta, A Tiwari, S Sharma, A Shukla, M Sharma, RK Vasishta, ...

International immunopharmacology 58, 15-23

2018

Spatiotemporally controlled ablation of Klf5 results in dysregulated epithelial homeostasis in adult mouse corneas

CL Loughner, A Tiwari, D Kenchegowda, S Swamynathan, ...

Investigative ophthalmology & visual science 58 (11), 4683-4693

2017

Expression of granulocyte colony stimulating factor and its receptor by retinal pigment epithelial cells: a role in maintaining differentiation-competent state

S Khera, A Tiwari, R Srinivasan, A Gupta, M Luthra-Guptasarma

Current eye research 36 (5), 469-480

2011

The secreted Ly6/uPAR-related protein-1 suppresses neutrophil binding, chemotaxis, and transmigration through human umbilical vein endothelial cells

S Swamynathan, A Tiwari, CL Loughner, J Gnalian, N Alexander, V Jhanji, ...

Scientific reports 9 (1), 1-11

2019

Current perspectives of limbal-derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

V Singh, A Tiwari, AR Kethiri, VS Sangwan

Stem Cells Translational Medicine 10 (8), 1121-1128

2021

Molecular and morphological evidence for cadaver vitreous-stimulated transformation of differentiation-competent retinal pigment epithelial cells into neuron-like cells

S Khera, A Tiwari, R Srinivasan, A Gupta, M Luthra-Guptasarma

Current Eye Research 37 (7), 606-616

2012

BMP6 Regulates Corneal Epithelial Cell Stratification by Coordinating Their Proliferation and Differentiation and Is Upregulated in Pterygium

A Tiwari, S Swamynathan, G Campbell, V Jhanji, SK Swamynathan

Investigative ophthalmology & visual science 61 (10), 46-46

2020

KLF4 coordinates corneal epithelial apical-basal polarity and plane of cell division and is downregulated in ocular surface squamous neoplasia

A Tiwari, S Swamynathan, V Jhanji, SK Swamynathan

Investigative ophthalmology & visual science 61 (5), 15-15

2020

Pathological vitreous causes cell line‐derived (but not donor‐derived) retinal pigment epithelial cells to display proliferative vitreoretinopathy‐like features in culture

M Sharma, A Tiwari, S Sharma, R Bansal, V Gupta, A Gupta, ...

Clinical & Experimental Ophthalmology 42 (8), 745-760

2014

Secreted Ly-6/uPAR Related Protein-1 (SLURP1) modulates inflammation by influencing both neutrophils and endothelial cells

S Swamynathan, A Tiwari, C Loughner, N Alexander, J Gnalian, ...

Investigative Ophthalmology & Visual Science 59 (9), 3325-3325

2018

Bone morphogenetic protein-6 (BMP6) coordinates corneal epithelial stratification by regulating proliferation and differentiation, and is upregulated in pterygium.

A Tiwari, S Swamynathan, G Campbell, V Jhanji, SK Swamynathan

Investigative Ophthalmology & Visual Science 61 (7), 4350-4350

2020

Secreted Ly-6/uPAR Related Protein-1 (SLURP1) modulates inflammation by moderating epithelial cells response to inflammatory agents

S Swamynathan, G Campbell, A Tiwari, JS Gnalian, SK Swamynathan

Investigative Ophthalmology & Visual Science 60 (9), 915-915

2019

Krüppel-like factor 4 (KLF4) Controls Corneal Epithelial Stratification by Regulating Cell Polarity and Plane of Cell Division

A Tiwari, S Swamynathan, N Alexander, J Gnalian, SK Swamynathan

Investigative Ophthalmology & Visual Science 59 (9), 3849-3849

2018