Early detection is often critical to the treatment of diseases. We are identifying novel biomarkers for patients with various corneal disorders, such as keratoconus, fuchs endothelial corneal dystrophy, to allow early detection. We have access to various anterior segment spectral domain OCT, Pentacam, slit-lamp photography, i-trace, and ocular surface analyzer devices. Artificial intelligence (AI) is changing healthcare. We are studying how we can apply AI and deep learning algorithms to ophthalmic imaging and functional testing to help with the diagnosis and prognosis of various eye diseases such as keratoconus.