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Dr. Akhil varshney
Dr. Akhil varshney
SCIENTIST D
RAMANUJAN FELLOW
Stem Cell Department
Dr. Shroff's Charity Eye Hospital
ABOUT
ABOUT
Dr. Akhil Varshney is a trained basic research scientist and he has more than 10 years of extensive research experience in the field of molecular biology; retina and ocular surface-cornea. During his post-doctoral training at University of Virginia, USA, he extensively worked on understanding the retinal biology and associated pathologies like age related macular degeneration (AMD) and dibetic retinopathy. His lab is actively working on the following areas
1. To understand the molecular mechanism underlying degeneration of RPE in AMD.
2. To understand the novel molecular mechanism that contributes to intraocular and metastatic extraocular retinoblastoma.
3. To understand the role of retrotransposons in various retinal and corneal disease.
4. To study the role of CTG repeat expansion in TCF4 gene in pathophysiology of FECD.
Selected Publications
Selected Publications
Role of AS-OCT in Managing Corneal Disorders
N Gupta, A Varshney, M Ramappa, S Basu, V Romano, M Acharya, ...
Diagnostics 12 (4), 918
DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs
S Wang, S Narendran, S Hirahara, A Varshney, F Pereira, I Apicella, ...
Science Immunology 6 (66), eabi4493
2021
Infectious Keratitis: An Update on Role of Epigenetics.
S Verma, A Singh, A Varshney, RA Chandru, M Acharya, J Rajput, ...
Frontiers in Immunology 12, 765890-765890
2021
Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration
M Ambati, I Apicella, S Wang, S Narendran, H Leung, F Pereira, ...
Proceedings of the National Academy of Sciences 118 (41)
2021
Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity
S Fukuda, S Narendran, A Varshney, Y Nagasaka, S Wang, K Ambati, ...
Science advances 7 (40), eabj3658
2021
S Narendran, F Pereira, P Yerramothu, I Apicella, S Wang, K Ambati, ...
Signal transduction and targeted therapy 6 (1), 1-9
2021
S Fukuda, A Varshney, BJ Fowler, S Wang, S Narendran, K Ambati, ...
Proceedings of the National Academy of Sciences 118 (6)
2021
J Ambati, J Magagnoli, H Leung, S Wang, CA Andrews, D Fu, A Pandey, ...
Nature communications 11 (1), 1-12
2020
S Narendran, F Pereira, P Yerramothu, I Apicella, S Wang, A Varshney, ...
Investigative ophthalmology & visual science 61 (10), 4-4
2020
S Narendran, D Banerjee, I Apicella, S Wang, A Varshney, S Fukuda, ...
Investigative Ophthalmology & Visual Science 60 (9), 990-990
2019
SS Yadav, M Kumar, A Varshney, PK Yadava
Life sciences 220, 169-176
2019
Non-integrated, reverse transcribed Alu complementary DNAs in Geographic Atrophy cause RPE toxicity
S Fukuda, BJ Fowler, T Yasuma, A Varshney, K Ambati, N Kerur, ...
Investigative Ophthalmology & Visual Science 59 (9), 2456-2456
2018
Diversity and functional evolution of the plasminogen activator system
RK Jaiswal, AK Varshney, PK Yadava
Biomedicine & Pharmacotherapy 98, 886-898
2018
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
N Kerur, S Fukuda, D Banerjee, Y Kim, D Fu, I Apicella, A Varshney, ...
Nature medicine 24 (1), 50-61
2018
MicroRNA-874–mediated inhibition of the major G1/S phase cyclin, CCNE1, is lost in osteosarcomas
T Ghosh, A Varshney, P Kumar, M Kaur, V Kumar, R Shekhar, R Devi, ...
Journal of Biological Chemistry 292 (52), 21264-21281
2017
Sld5 ensures centrosomal resistance to congression forces by preserving centriolar satellites
M Kaur, R Devi, T Ghosh, MM Khan, P Kumar, Priyanka, A Kar, A Sharma, ...
Molecular and cellular biology 38 (2), e00371-17
2017
A Varshney, J Bala, B Santosh, A Bhaskar, S Kumar, PK Yadava
Molecular and cellular biochemistry 427 (1), 157-167
2017
RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling
A Kar, M Kaur, T Ghosh, MM Khan, A Sharma, R Shekhar, A Varshney, ...
Nucleic acids research 43 (10), 4962-4974
2015
Global expression profile of telomerase-associated genes in HeLa cells
A Varshney, SK Ramakrishnan, A Sharma, B Santosh, J Bala, PK Yadava, ...
Gene 547 (2), 211-217
2014
SK Ramakrishnan, A Varshney, A Sharma, BC Das, PK Yadava
Tumor Biology 35 (6), 5539-5550
2014
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