Author: Stuart H. Friess is a doctor in the division of Critical Care Medicine, Department of Pediatrics in Washington University in St. Louis School of Medicine in Missouri USA. He has 63 Publications which all include pediatric studies.
Paper 1
Celorrio, M., Abellanas, M. A., Rhodes, J., Goodwin, V., Moritz, J., Vadivelu, S., Wang, L., Rodgers, R., Xiao, S., Anabayan, I., Payne, C., Perry, A. M., Baldridge, M. T., Aymerich, M. S., Steed, A., & Friess, S. H. (2021). Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis. Acta neuropathologica communications, 9(1), 40.
This paper, Friess looked at how antibiotics can affect the healing from TBIs. After concussing the mice, they gave them antibiotics to see if the reduction of gut microbiota had an impact on brain plasticity and cell renewal. They found that lack of specific bacteria can help tissue repair as well as long term recovery.
Paper 2
Davies, M., Jacobs, A., Brody, D. L., & Friess, S. H. (2018). Delayed Hypoxemia after Traumatic Brain Injury Exacerbates Long-Term Behavioral Deficits. Journal of neurotrauma, 35(5), 790–801.
This paper Friess looked at how delayed hypoxia after a TBI affects long term behavior. Sometimes patients will go into a state of hypoxia while being treated, however, because hypoxic patients often have a high mortality rate, this study wanted to see the long-term results. In this case, there were long term behavioral deficits which were shown through the longer time for the swim test and less social interaction than the control mice.
Paper 3
Celorrio, M., Shumilov, K., Payne, C., Vadivelu, S., & Friess, S. H. (2022). Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury. Acta neuropathologica communications, 10(1), 10.
Minocycline is a neuroprotective antibiotic that could be used to help TBI patients in the ICU. In this preclinic trial they picked the most promising patients to be dosed with minocycline. They looked at the patients 6 months after the injury. They found that the dosage improved fear memory performance long term. However, there needs to be more information on what timing to dose the patients for optimal results.