Rubovitch, V., Ten-Bosch, M., Zohar, O., Harrison, C. R., Tempel-Brami, C., Stein, E., Hoffer, B. J., Balaban, C. D., Schreiber, S., Chiu, W. T., & Pick, C. G. (2011). A mouse model of blast-induced mild traumatic brain injury. Experimental neurology, 232(2), 280–289.
This study looked at inducing mild TBIs in mice to simulate the TBIs humans face after IEDs. The mice were anesthetized before being placed either 4 or 7 meters away from a TNT explosion. They found long term cognitive abnormalities. The data show that blast induced TBIs should be considered differently than other TBIs. This study is useful because it shows that I can induce TBIs on animals ethically. It also shows that I should not concuss the animal via explosions in the research proposal.