Cancer Genomics / Genetics &
Functional Characterizations
Jim J.‐C. Sheu’s Lab
Cancer Genomics / Genetics &
Functional Characterizations
Jim J.‐C. Sheu’s Lab
Cancer development is a process of accumulation of genetic alterations. The success of cancer genomics project has advanced our understanding of cancer etiology, however, the underlining mechanisms still remain elusive, especially for those altered genes which were previously considered as passengers. Accumulating data provide deniable evidence that certain mutations in cancer may function as Achille’s heel which provides us the opportunity to utilize them as targets for cancer treatments.
Cancer Genomics/Genetics
To define cancer‐driving genes using genome-wide technologies and
characterize their functions in the development of oral, ovarian and
bladder cancers.
Selected Publications
1. Cancer Res. (2009) 69:1407‐15.
2. Cancer Res. (2009) 69:2568‐76.
3. J Biol Chem (2010) 285:38260‐9.
4. J Pathol (2011) 224:367‐76.
5. J Pathol. (2013) 229:559‐68.
6. Oncogene (2014) 33:1375‐84.
7. Oncogene (2019) 3:5113‐26.
8. J Pathol (2019) 248:476‐87.
9. Mol Oncol (2020) 14:3065.
10. Theranostics (2020) 10:12026.
Personalized Precision Medicine
To define genetic/protein markers for personalized
prognosis of human cancers, endometriosis, type‐2
diabetes, and the associated complications.
Selected Publications
1. Cancer Epidemiol Biomarkers Prev.(2009) 18:2709‐16.
2. BMC Med (2011) 9:19.
3. Am J Pathol (2011) 178:2407‐15.
4. Am J Pathol (2012) 180:1179‐88.
5. BMC Med Genet (2015) 16:60.
6. Oncotarget (2016) 7:76713.
7. Sci Rep (2020) 10:3953.
8. Diagnostics (2020) 10:657.
9. Biomedicines (2022) 10:185.
10. J Pers Med (2022) 12:172.