B. Mechanobiology in Cancer Signaling
Mol Oncol (2020) 14:3065‐82. (IF: 6.603; Rank: 52/313 = 16.61 % in Oncology)
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MB21D1, a cadherin-binding molecule, was identified as a signaling regulator for KRAS and PI3K pathways. Anti- MB21D2 therapy was found effective to treat cancers with active KRAS or PI3K signaling networks.
Theranostics (2020) 10:12026-43. (IF: 11.556; Rank: 9/189 = 4.76 % in Medicine, Research & Experimental)
Heterophilic interactions between melanocyte and keratinocyte maintain skin homeostasis. UVinduced CDH mutations cause contact control loss from keratinocyte and trigger melanomagenesis. During metastasis, mutation-derived Neo-Ags boost T-lymphocytes and activate anti-cancer immunity, which in a reverse way is beneficial for immunotherapy.
Oncogene (2019) 38:5113-26. (IF: 9.867; Rank: 12/188 = 6.38 % in Genetics & Heredity; Citation = 5)
This is the first report to reveal the involvement of keratin fusions in cancer development. Cancer aggressiveness and stemness triggered by alterations in mechanical properties of cells open a new field in cancer biology. This study was also reported as Taiwan Research Highlight in GASE (MOST Center for Global Affairs and Science Engagement) in Sep 2019.
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