The cardiovascular system is responsible for the transport of oxygen-rich blood throughout the body. The cardiovascular system is controlled on a beat-by-beat basis by the autonomic nervous system. After spinal cord injury, disruption of autonomic control, changes in metabolic profile and inactivity combine to alter the functioning of the cardiovascular system at rest and especially during exercise. Cardiovascular function broadly refers to the function of the heart and blood vessels located both peripherally and centrally within the brain and spinal cord. A focus of rehab is the primary prevention of heart disease through exercise prescription and optimization of lipid profile.