pathogen. Moreover, the term “quarantine” ought to be used in the context of groups or at community level (Dsouza et al., 2020; Sánchez-Villena and de La Fuente-Figuerola, 2020). “Social isolation” refers to the restriction of social movement of those infected with the disease (Dsouza et al., 2020; Sánchez-Villena and de La Fuente-Figuerola, 2020). Meanwhile, “social distancing” is a preventative measure recommended to the general population to flatten the curve of the contagious disease. In this scenario, people are advised to stay at home and use services as little as possible, as well as to avoid agglomerations, maintain the recommended distance of one meter from each other and take precautionary measures to avoid infection (Covid-19, 2020). Nevertheless, the use and the comprehension of these terms should not be so inflexible. In fact, the term “social isolation” has also been used to express the source of subjective feelings of solitude that may accompany the social distancing measures, especially for those who are already at enhanced risk of suffering from loneliness. Notwithstanding, the term “social disconnection” is used in this review to encompass this framework. Source of Psychological Impact Related to the Restricting Measures It is undeniable that the restricting measures imposed to contain the COVID-19 pandemic have a severe impact on the mental health of the population. Nonetheless, it is yet unclear what promotes such negative effects. It is possible that these repercussions derive directly from the restrictive strategies and reduced social mobility (Bavel et al., 2020; Brooks et al., 2020; Pfefferbaum and North, 2020; Wang G. et al., 2020). However, the emotional and psychological outcomes of the pandemic may also be secondary to the intrinsic changes that the restricting measures cause in lifestyle habits and socioeconomic scenario (Brooks et al., 2020; Zhu et al., 2020). Key Components of the Emotional and Behavioral Response to COVID-19 Pandemic The emotional and behavioral response to COVID-19 pandemic is multifactorial. It relies not only on external components, but on personal and innate ones as well. Nonetheless, the reaction to the current circumstances seem to have predominant elements in the overall population. A significant increase in feelings of functional impairment, boredom, stigma, worry, phobia, frustration and anger has been observed (Ahmadi and Ramezani, 2020; Brooks et al., 2020; Pfefferbaum and North, 2020; Restubog et al., 2020; Sher, 2020a; Teufel et al., 2020). In this topic, some selected factors must be discussed thoroughly due to its pivotal influence on the mental health impact of the pandemic. Fear and Uncertainty Unlike other virus outbreaks of the 21st century, such as SARS and MERS, which were primarily disseminated in hospital environments (Bai et al., 2004; Cauchemez et al., 2016), COVID-19 is unique in the way that it has spread far beyond health centers’ borders. With the entire population at risk, the necessary restricting measures have created an unparalleled scenario, dominated by fear and uncertainty. Even though fear is an essential adaptive mechanism that humans and other species have developed to cope with threats in the environment, it can only be supportive for those who feel capable of dealing with the menaces presented specifically to them. To those who consider themselves as unable to handle such risks, fear can trigger defense responses (Bavel et al., 2020). And so, in a