Efficacy abstract

Abstract

OXIDATIVE STRESS (O.S) BASED EFFICACY 

Suggestions based on research published papers on individual properties of functional waters such as alkaline water, alkaline ionized water, ionized water, reduced water, vitamin water, hydrogenated water, electrolyte water, activated water, structured water, hydrogen water, blend water, electrolyzed water, NORP water, synchronized water.

The efficacy is based on a proprietary process manufactured water-based beverage, termed as 

Nutrient Enriched Alkaline Ionized Hydrogen rich Hypotonic Electrolyte Synchronized Water

a ready to drink therapeutic water based beverage, “Nireta” trademark with “In vivo” consumption period of 21 days from different field, volume quantity 1.0 - 2.0 litre/day based on records maintained on initial health condition, age, gender, working style, weight, exercise routine (if), daily physical activity, alcoholic consumptive pattern (if), smoking pattern (if), food habits (vegetarian or non-vegetarian), general hydration pattern, sleep pattern & daily commute or travel, stress level, etc

The initial and final report is generated based on biomarker evaluation. “In vitro” conducted in a controlled environment.

The WHO defined a biomarker as 

“any substance, structure, or process that can be measured in the body or its products and influence or predict the incidence of outcome or disease”.

The selection of reliable biomarker of oxidative stress fulfils the following criteria:

(a) clinical relevance (b) specificity for certain diseases (c) reflect the stage of the disease, (d) quantification of the biomarkers shows a high degree of reproducibility.

Markers related to oxidative stress can be divided into several categories: 

(a) Markers of ROS formation, (b) Markers of Antioxidant protection, (c) Biomarkers of ROS-induced modifications, (d) ROS damage by downstream functional markers. 

Incorporated Ingredients indirectly influence Nrf2 activity by Supporting Cellular Health: 

Ascorbic acid acts as activator of the Nrf2 factor promotes the expression of antioxidant enzymes.

Niacin regulates the Nrf2 pathway by downregulating gene expression in turn activates the cytosolic NADPH production through regulation of four main enzymes. Pyridoxine stimulates Nrf2/HO-1 pathway upregulates anti oxidant enzyme, promotes cellular defense mechanism.

Activated B12 form, methyl cobalamin up-regulates the expression of the Nrf2/HO-1 pathway protects cells by increased antioxidant activity. 

Dissolved molecular hydrogen scavenges ROS by activating the Nrf2 pathway, improves Nrf2 signalling.

Compiled by Prash beverages.