日本学術振興会二国間交流事業
JSPS-DAAD Bilateral Collaboration (Japan & Germany)

Rationale drug design and treatment protocol
based on singlet oxygen imaging for PDT

日時：2025年9月19日（金）13:30~17:30
場所：ナノ医療イノベーションセンター3001会議室・オンラインのハイブリッド開催
主催：東京大学野本研究室、ナノ医療イノベーションセンター
参加費：無料（参加登録をお願いします）
参加登録（現地参加、先着20名程度）：https://forms.gle/rtqYcAovt9zfQde86
参加登録（オンライン）：https://us06web.zoom.us/webinar/register/WN_DTFBRfNXRheEdYOjyfCz9Q#/registration

日本学術振興会二国間交流事業（日独共同研究）において、一重項酸素イメージングに基づく光線力学療法（PDT）の薬剤設計と治療プロトコルの合理化を進めています。本共同研究の枠組みを拡げ、PDTの国際共同研究を活発化することを目的として研究会を開催することになりました。

まず、ドイツ側代表のAdj. Prof. Steffen Hackbarth（ベルリン・フンボルト大学）に、独創性の高い一重項酸素イメージング技術とPDTにおける酸素濃度の重要性について紹介していただきます。また、臨床でPDTを実施しながら基礎研究も進めていらっしゃる共同研究者の永井健太先生（東京医科大）をお呼びし、臨床医の視点から最近のPDT研究について紹介していただきます。そして、日本側代表の野本（PI）がPDTにおける薬剤設計の合理化の必要性について説明し、ナノ医療イノベーションセンターでドラッグデリバリーシステム（DDS）の開発に携わるDr. Haochen Guo, Dr. Sabina Quaderから最近の研究成果について紹介していただきます。

光医療、DDSに興味をお持ちの方は是非お気軽にご参加ください！
参加登録（現地参加、先着20名程度）：https://forms.gle/rtqYcAovt9zfQde86
参加登録（オンライン）：https://us06web.zoom.us/webinar/register/WN_DTFBRfNXRheEdYOjyfCz9Q#/registration

13:30-13:35 Opening Remarks Drs. Haochen Guo (iCONM) and Takahiro Nomoto (UTokyo)

13:35-14:35 Singlet oxygen imaging Adj. Prof. Steffen Hackbarth (Humboldt-Universität zu Berlin)

14:35-15:20 iPDT for malignant gliomas Assist. Prof. Kenta Nagai (Tokyo Medical University)

15:20-15:30 Coffee Break

15:30-16:20 Drug delivery for photomedicine Assoc. Prof. Takahiro Nomoto (the University of Tokyo)

16:20-16:50 Application of Iron Chelator in 5-ALA PDT Dr. Haochen Guo (iCONM)
16:50-17:20 Polymeric NanoMedicine for Brain Cancer Dr. Sabina Quader (iCONM)

17:20-17:30 Closing Remarks Prof. Emer. Kazunori Kataoka

Adj. Prof. Steffen Hackbarth
Department of Physics, Humboldt-Universität zu Berlin

Steffen Hackbarth is a physicist. His work is focused on NIR spectroscopy with the highest possible sensitivity, especially of singlet oxygen phosphorescence . The technology developed by his group is unchallenged in the world at the moment - parts of this technology are available via the spin-off SHB Analytics GmbH. Besides this, he is interested in the mechanism behind the primary steps of photosensitization in vivo.

His recent work includes collaboration with Prof. Hiroshi Maeda, revealing important aspects of oxygen during PDT.

Assist. Prof. Kenta Nagai
Department of Neurosurgery, Tokyo Medical University

Kenta Nagai is a clinician specializing in neurosurgery. His group was the first in the world to conduct investigator-initiated clinical trials of PDT using talaporfin sodium (Laserphyrin®) for malignant brain tumors and to have the drug covered by insurance. The clinical results of PDT for malignant brain tumors are the world's top class, with more than 100 cases since the insurance coverage was implemented. His recent study revealed that light intensity in interstitial PDT critically affects the ultimate therapeutic efficacy.

Assoc. Prof. Takahiro Nomoto
Graduate School of Arts and Sciences, the University of Tokyo

Takahiro Nomoto’s expertise is in biomaterials and drug delivery. He develops drug delivery systems by re-interpreting/constructing Ringsdorf's model of polymer-drug conjugates. He has recently developed polymer-drug conjugates for photodynamic therapy and polymeric iron chelators for potentially modulating the tumor microenvironment. His team conducts research to create new medical technologies by integrating various research fields with a focus on drug delivery. His recent interest is in making PDT precise and quantitative.

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日本学術振興会二国間交流事業JSPS-DAAD Bilateral Collaboration (Japan & Germany)

Rationale drug design and treatment protocolbased on singlet oxygen imaging for PDT

Adj. Prof. Steffen HackbarthDepartment of Physics, Humboldt-Universität zu Berlin

Assist. Prof. Kenta NagaiDepartment of Neurosurgery, Tokyo Medical University

Assoc. Prof. Takahiro NomotoGraduate School of Arts and Sciences, the University of Tokyo

日本学術振興会二国間交流事業
JSPS-DAAD Bilateral Collaboration (Japan & Germany)

Rationale drug design and treatment protocol
based on singlet oxygen imaging for PDT

Adj. Prof. Steffen Hackbarth
Department of Physics, Humboldt-Universität zu Berlin

Assist. Prof. Kenta Nagai
Department of Neurosurgery, Tokyo Medical University

Assoc. Prof. Takahiro Nomoto
Graduate School of Arts and Sciences, the University of Tokyo