SNS2017
Satellite Symposium
NEUROACTIVE STEROIDS AND
METABOLIC AXIS
February 11 - Torino
Organizers: Collado P (Spain), Melcangi R.C. (Italy), Panzica G.C. (Italy)
10.00 Introduction to the Symposium
10.30 Herman J.P. de Kloet A.D. (USA) Glucocorticoid signaling, stress and metabolism mechanisms of glucocorticoid feedback: role of the adipocyte
11.00 Melcangi R.C. (Italy) Neuroactive steroids and diabetic complications in the nervous system
12.00 Argente-Arizón P., Freire-Regatillo A., Diez F., Argente J., Chowen, J.A. (Spain) Sex steroids and glia in the neuroendocrine control of metabolism
12.30 Tena-Sempere M. (Spain) Estrogens and the integral control of energy homeostasis and related body functions: a brain perspective
13.00 Herber C., Krause W., Cain C., Wang L., Hsaio E., Nissenson R., Fields A., Correa S., Ingraham H.A. (USA) Estrogen-responsive neurocircuits modulate female energy and bone homeostasis
15.00 Collado P., Carrillo B., Díaz F., Chowen J.A., Pinos H. (Spain) Sex differences in the response to malnutrition. Can estradiol modulates malnutrition effects?
15.30 Bäckström T., Holmberg E., Haage D., Sjöstedt J., Malinina E., Lundkvist A., Turkmen S., Löfgren M., Ragagnin G., Johansson M. (Sweden) Allopregnanolone involvement in feeding regulation, overeating and obesity
16.00 Panzica G.C., Farinetti A., Bo E., Marraudino M., Ponti G., Gotti S. (Italy) Metabolic disrupting chemicals and peptidergic pathways controlling food intake and energy metabolism
16.30 Dudek M., Kołodziejski P.A., Pruszyńska-Oszmałek E., Ziarniak K., Sliwowska J.H. (Poland) Effects of orchidectomy and testosterone replacement on numbers of kisspeptin-, neurokinin B-, and dynorphin A-immunoreactive neurons in the arcuate nucleus of the hypothalamus in obese and diabetic rats
16.45 General discussion and Closure of the Satellite Symposium
9th International Meeting
STEROIDS and NERVOUS SYSTEM
FEBRUARY 11
17.30 - Opening Ceremony
18.00 OPENING LECTURE
Chair: Tena Sempere M. (Spain)
Herbison A. (New Zealand)
Estrogen feedback to the GnRH neurons
19.00 Welcome cocktail
FEBRUARY 12
Symposium 1 - MOOD DISORDERS AND STRESS
Chairs: Brunton P.J. (UK), Riva M.A. (Italy)
9.00 Shannon Weickert C., Owens S.J., Purves-Tyson T.D., Webster M.J., Weickert T.W. (Australia) Increased adolescent testosterone sets the stage for schizophrenia
9.30 Wiechmann T., Roeh S., Czamara D., Sauer S., Koedel M., Provençal N., Binder E.B. (Germany) Cross-tissue relevant epigenetic changes in the FKBP5 locus: relevance for stress-related psychiatric disorders
10.00 Meijer O.C. (The Netherlands) Glucocorticoid receptors in brain stress circuits: downstream signalling and cell specific effects
11.00 Lai Y., Brunton P.J. (UK) A role for hippocampal mineralocorticoid receptors in differentially modulating spatial learning under stressful conditions in prenatally stressed rats
11.15 Cattaneo A., Luoni A., Cattane N., Pape J., Mariani N., Binder E.B., Riva M.A., Pariante C.M. (Italy) Long lasting SGK1 modulation in response to early life stress: focus on epigenetic mechanisms
11.30 Amianto F., Abbate Daga G., Fassino S. (Italy) Gender differences in the personality traits: hormones or attachment?
11.45 Giatti S., Santi D., Spezzano R., Grimoldi M., Tabacchi T., Fusco M.L., Diviccaro S., Carra G., Caruso D., Simoni M., Cavaletti G., Melcangi R.C. (Italy) Post-finasteride syndrome: neuroactive steroid levels, psychiatric and andrological features
12.00 Weickert T.W., Ji E., Kyaw M., Moore L.T., Morris R., Vercammen A., Shannon Weickert C. (Australia) Testosterone influences cognition and brain activity in men with schizophrenia
12.15-13.00 PLENARY LECTURE
Chair: Mensah-Nyagan A.G. (France)
Papadopoulos V. (USA)
Translocator protein (18 kDa): an update on its structure and function
Symposium 2 - SIGNALING PATHWAYS
Chairs: Arévalo A. (Spain), Vallée M. (France)
15.00 Kelly M.J., Qiu J., Wagner E.J., Rønnekleiv O.K. (USA) Integration of the anorexigenic effects of estradiol and metabolic hormones by hypothalamic arcuate neurons
15.30 Brown A.R., Mitchell S.J., Herd M.B., Belelli D., Lambert J.J. (UK) Developmentally regulated pregnane steroid synthesis enhances GABA-ergic neurotransmission in mouse thalamocortical neurons and cortical pyramidal neurons
16.00 Tasker J.G., Chen C., Jiang Z., Weiss G. (USA) Stress desensitization of hypothalamic adrenoreceptors via a rapid, glucocorticoid receptor-dependent mechanism
17.00. Frye C.A., Walf A.A. (USA) Pregnane xenobiotic receptor (PXR) knockout rats respond to allopregnanolone but neither ligands for progestin receptors nor PXR for neurosteroid-mediated motivated behaviors
17.15 Hsu C-Y, Wu T-H, Wu R-Y, Lu K-T, Chung B-c (Taiwan) Neurosteroid pregnenolone stabilizes cytoskeletons to promote brain functions
17.30 de Bournonville C., de Bournonville M.P., van Eeckhaut A., Smolders I., Ball G.F., Balthazart J., Cornil C.A. (Belgium) Changes in preoptic estradiol and glutamate concentration in the preoptic area during male sexual behavior
17.45 Inoue M., Matsuoka H., Harada K. (Japan) Regulation of GABA signaling by adrenal cortical steroids in adrenal medullary cells
FEBRUARY 13
Symposium 3 - SEX DIFFERENCES
Chairs: Garcia-Segura L.M. (Spain), Melcangi R.C. (Italy)
9.00 Gaignard P., Fréchou M., Liere P., Thérond P., Schumacher M., Slama A., Guennoun R. (France) Sex differences in brain mitochondrial metabolism: influence of endogenous steroids and effect of stroke
9.30 Cambiasso M.J. Cisternas C.D. (Argentina) Sex chromosome effects on aromatase expression and regulation in mouse developing brain
10.00 Bonthuis P.J., Addison M.L., Quinnies K.M., Harris E.P., Rissman E.F. (USA) Sex differences in neural growth hormone and body weight: effects of X-chromosome gene dosage and estradiol
11.00 Monks D.A., Swift-Gallant A. (Canada) Non-neural androgen receptors affect sexual differentiation of brain and behavior
11.30 Van Hemmen J., Bakker J. (Belgium) The sexual differentiation of the human brain is affected by multifactorial mechanisms: evidence from the complete androgen insensitivity syndrome
11.45 Bender R.A., Zhou L., Vierk R., Brandt N., Keller A., Gee C.E., Schäfer M.K.E., Rune G.M. (Germany) Sex-dependent regulation of aromatase-mediated synaptic plasticity in basolateral amygdala
12.00 Farinetti A., Marraudino M., Ponti G., Gotti S., Panzica G.C. (Italy) Sexually dimorphic effect of chronic treatment with tributyltin on brain circuits involved in the food intake behavior in adult mice
12.15-13.00 PLENARY LECTURE
Chair: Panzica G.C. (Italy)
Forger N. (USA)
Epigenetic mechanisms in sexual differentiation of the brain and behavior
Symposium 4 - FOCUS ON HUMAN BRAIN
Chairs: Balthazart J. (Belgium), Frye C.E. (USA)
15.00 Nguyen T.-V. (Canada) Developmental effects of androgens in the human brain
15.30 Brinton R.D. (USA) Metabolic aging of the female brain: risks and consequences
16.00 Bixo M., Johansson M., Bäckström T. (Sweden) Effects of GABA active steroids in the female brain with focus on the premenstrual dysphoric disorder
17.00-18.30
Round Table - STEROIDS AND GUT MICROBIOME/BRAIN AXIS
Chairs: Melcangi R.C. (Italy), Panzica G.C. (Italy), Tetel M. (USA)
Tetel M.J. (USA) Estradiol and diet alter the gut microbiome in female mice
O’ Mahony S.M. (Ireland) The role of the microbiota in disorders of the gut-brain axis
de Vries G.J., Holder M.K., Peters N.V., Whylings J., Fields C.T., Chassaing B., Gewirtz A.T. (USA) Food, microbiota, and behavior
FEBRUARY 14
Symposium 5 - NEW TECHNOLOGIES TO UNDERSTAND THE FUNCTIONS OF STEROID RECEPTOR EXPRESSING NEURONS IN VIVO
Chairs: Herbison A.E. (New Zealand), Panzica G.C. (Italy)
9.00 Kawata M. (Japan) Behavior is regulated by steroid hormone receptor-associated mechanism: lesson from new animal model
9.30 Khayum M.A., Doorduin J., Dierckx R.A.J.O., de Vries E.F.J. (Netherlands) PET imaging of steroid hormone receptors
10.00 Maggi A., Rizzi N. and Ciana P., Vegeto E., Villa A. (Italy) Endocrine influence on neuroinflammation: the use of reporter systems
11.15-12.00 SPECIAL LECTURE
Chair: Mitro N. (Italy)
Cartier N (France)
CYP46A1 and Modulation of brain cholesterol metabolism as a therapeutic approach for Alzheimer disease.
Symposium 6 - NEUROPROTECTION AND NEUROINFLAMMATION
Chairs: Garcia-Segura L.M. (Spain), Viviani B. (Italy)
15.00 Brann D., Sareddy G., Zhang Q., Wang R., Vadlamudi R. (USA) Role of the ER coregulator, PELP1 in mediating the neuroprotective, anti-inflammatory and cognitive-enhancing effects of estrogen in the brain
15.30 Beyer C., Hoffmann S. (Germany) Sex steroids and inflammasomes: a neuroprotective alliance in the brain
16.00 Pak T.R. Shults C.L., Dingwall, C.B., Kim C.K. (USA) Functional dynamics of estrogen receptor-beta in the aging female brain
17.00 De Nicola A.F., Garay L., Meyer M., Sitruk-Ware R., Guennoun R., Schumacher M., Gonzalez Deniselle M.C. (Argentina) Neurosteroidogenesis and progesterone anti-inflammatory/neuroprotective effects
17.30 Schumacher M., Bielecki B., Ghoumari A., Franklin R.J.M., Ghandour M.S., Traiffort E. (France) The unexpected role of testes, testosterone and the androgen receptor in spontaneous myelin regeneration
17.45 Morello M., Millet P., Landel V., Feron F. (Italy) Vitamin D and Alzheimer’s disease: a new perspective
FEBRUARY 15
Symposium 7 - ESTROGENS ACROSS THE LIFESPAN: RAPID AND CHRONIC INFLUENCES OF ESTROGENS ON STRUCTURAL PLASTICITY, MEMORY AND DISEASE
Chairs: Choleris E. (Canada), Galea L.A.M. (Canada)
9.00 Galea L.A.M. (Canada) Good news and bad news: the effects of estrogens on cognition and neuroplasticity during aging
9.30 Srivastava D.P. (UK) Rapid regulation of dendritic spine plasticity in health and disease
10.00 Choleris E., Phan A., Lymer J.M., Sheppard P.A.S., Ervin S.J.K. (Canada) Brain regions involved in the rapid action of estrogens and their receptors on learning
11.00 Sohrabji F. (USA) Estrogens and neuroprotection after stroke: effects of age
11.30 Mehta D., Rex-Haffner M., Pinborg A., Binder E.B., Frokjaer V.G. (Denmark) Gene expression profiles within a pharmacologically induced depression model – the role of estrogen in perinatal depression
11.45 Marraudino M., Ponti G., Farinetti A., Macchi E., Gotti S., Keller M., Collado P., Panzica G.C. (Italy) The sexually dimorphic obesogenic effect of early postnatal genistein administration on CD1 mice
12.00 Clark S., Rainville J., Vasudevan N. (United Kingdom) Can aggression in male mice be regulated in a non-genomic manner by steroids?
12.15-13.00 PLENARY LECTURE
Chair: Balthazart J. (Belgium)
Micevych P. (USA)
Estradiol membrane-initiated signaling and female reproduction
14.15-15.30 YOUNG INVESTIGATORS Symposium
Chairs: Frye C.A. (USA), Giatti S. (Italy), Mensah-Nyagan A.G. (France)
Du X., McCarthny C.R., Schroeder A., Notaras M.J., Grech A., Hill R.A. (Australia) BDNF maintains normal estrous cycling – relevance to schizophrenia
Overgaard A., Lieblich S.E., Wong S., Galea L.A.M., Frokjaer V.G. (Denmark) Behavioural and hippocampal changes across the pre- to postpartum transition in rats
Mitchell S.J., Maguire E.P., Swinny J.D., Seifi M., Belelli D., Lambert J.J. (Scotland) Neurosteroids: endogenous modulators of the GABAA receptors of the nucleus accumbens
Nuzzo M.T., Marino M. (Italy) Novel application for estrogen receptor β ligands
Yanguas-Casás N., Crespo-Castrillo A., Arevalo M.A., Garcia-Segura L.M. (Spain) Sex differences in the phagocytic and migratory capacity of rat microglia
Silva M.S.B., Prescott M., Campbell R.E. (New Zealand) Dissecting the GABA-to-GnRH neuron network in the pathophysiology of polycystic ovary syndrome (PCOS)
CLOSURE OF THE MEETING