SNS2013
7th INTERNATIONAL MEETING
STEROIDS AND NERVOUS SYSTEM
TORINO – Orbassano - February 16-20, 2013
February 16 (Dept. Neuroscience - Anatomical Institute, Torino)
Satellite Symposium
ALLOPREGNALONONE: STATE OF ART
Organizers: R.D. Brinton (USA), R.C. Melcangi (Italy) and G.C. Panzica (Italy)
Melcangi R.C. (Italy), Giatti S., Calabrese D., Mitro N., Viviani B., Garcia-Segura L.M., Caruso D. - Neuroactive steroid levels in physiological and pathological status: focus on progesterone metabolites.
Lambert J.J. (UK), Brown A.R., Gunn B.G., Belelli D. - Neurosteroids: Local modulators of neuronal GABA-A receptors
Darbra S., Mòdol L., Llidó A., Casas K., Navarro X., Vallée M., Pallarès M. (Spain) - Neonatal allopregnanolone levels alteration: effects on behaviour and role of the hippocampus
Nothdurfter C. (Germany), Schüle C., Rupprecht R. - The role of allopregnanolone in depression and anxiety
Backstrom T. (Swedeen), Nyberg S., Strömberg J., Ragagnin G., Timby E., vanWingen G., Ossewaarde L., Bixo M., Savic I. - Allopregnanolone and mood disorders
Schumacher M. (France), Liu A., Liere P., Sitruk-Ware R1., Ghoumari A., Guennoun, R. - Allopregnanolone and progesterone receptors: their respective significance in myelination and neuron viability
Brinton R.D. (USA) Allopregnanolone as a Regenerative Therapeutic for Alzheimer's Disease: Current Status and Future Promise
Patte-Mensah C., Meyer L., Taleb O., Mensah-Nyagan A.G. (France) - Therapeutic potential of neurosteroid allopregnanolone for the treatment of neuropathic pain
Hirst J.J. (Australia), Bennett G.A., Kelleher M.A, Walker D.W., Palliser H.K - Neurosteroid disruption leads to adverse outcomes following compromised pregnancy and premature birth.
Brunton P.J. (UK), Donadi M.V., Yao S.T., Greenwood M., Paris J.J., Frye C.A., Murphy D., Russell J.A. - Sex-dependent overwriting of prenatally programmed stress responses with neuroactive steroids
February 16
18.00 HISTORICAL LECTURE
Balthazart J. (Belgium) Steroid action in the brain: a historical viewpoint from Torino
(Chair: García-Segura L.M.)
February 17 - Department of Clinical and Biological Sciences, Hospital San Luigi, Regione Gonzole 10, Orbassano (Turin).
NEUROACTIVE STEROIDS AND PSYCHIATRIC DISORDERS
Chair: T. Backstrom (Sweeden) & M.A. Riva (Italy)
Biagini G. (Italy), Rustichelli C., Curia G., Lucchi C., Pugnaghi M., Meletti S., Avoli M. - Neurosteroids and epileptogenesis
Bortolato M. (USA) - Role of 5alpha-reductase in behavioral regulation: relevance to schizophrenia and other neuropsychiatric disorders
Frye C.A. (USA) - Pregnane xenobiotic receptors and membrane progestin receptors, sources and targets, for neurosteroid-mediated motivated behavior
Iacobas D.A., Iacobas S., Chachua T., Sidyelyeva G., Goletiani C., Velíšková J., Velíšek L. (USA) - Modification of glutamatergic and GABAergic synapse gene fabric by prenatal corticosteroids
Dalla C. (Greece), Kokras N., Pastromas N., Kafetzopoulos V., Balthazart J., Cornil C. A., Papadopoulou-Daifoti Z. - Blockade of neuroestrogens enhances depressive behavior of female, but not male rats in the forced swim test
Wong P., Chang C.C.R., Marx C.E., Caron M.G., Wetsel W.C., Zhang X. (Singapore) - Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice
PLENARY LECTURE
Chair: A.G. Mensah-Nyagan (France)
Belelli D. (UK), Gunn B.G., Cunningham L., Lambert J.J. - Neurosteroids and GABA(A) Receptor Interactions: A Focus on Stress.
NEUROPROTECTIVE EFFECTSChair: L.M. Garcia-Segura (Spain) & B. Viviani (Italy)
De Nicola A.F. (Argentina), Gonzalez-Deniselle M.C., Garay L., Meyer M., Gargiulo-Monachelli G., Guennoun R., Schumacher M., Carreras M.C., Poderoso J.J. - Progesterone protective effect in neurodegeneration and neuroinflammation
Gravanis A. (Greece) - Cross-talk of neurosteroids and neurotrophins in controlling neuronal survival
Sohrabji F. (USA), Selvamani A., Miranda R.C. - Estrogen-IGF-microRNA interactions in stroke neuroprotection.
Saldanha C.J. (USA), Duncan K.A. - Cell‐specific provision of estrogens in the songbird brain
Yadid G. (Israel), Croitoru O., Sudai E., Ben-Tzion M. , Gispan I- Dehydroepiandrosterone reverse cocaine-induced decrease in hippocampus neurogenesis and attenuate reinstatement
Ghandour M.S. (France), Hussain R., Ghoumari M.A., Schumacher M. - Androgen receptor is a therapeutic target for myelin repair
IN MEMORY OF ROBERT PURDY - G. Biggio (Italy), M. Vallée (France)
(chair R.C. Melcangi)
February 18
MECHANISMS OF RAPID REGULATION OF BEHAVIOR BY ESTROGENS
Chair: C.A. Cornil (Belgium) & G.C. Panzica (Italy)
Deepak P. Srivastava D. (UK) - Molecular mechanisms underlying rapid estrogenic-modulation of cortical connectivity
Remage-Healey L. (USA) - Rapid synthesis and action of estrogens within forebrain circuits in the context of behavior
Cornil C.A. (Belgium) - Rapid control of reproductive behavior by locally synthesized estrogens-focus on aromatase
Phan A., Ervin K., Gabor C.S., Choleris E. (Canada) - Rapid estrogenic regulation of social and non-social learning
Filová B., Malinová M., Bábíčková J., Tóthová Ľ., Ostatníková D., Celec P., Hodosy J. (Slovakia) - Non-genomic effect of steroid hormones on behavior
Seredynski A.L. (Belgium), Balthazart J., Ball G.F., Cornil C.A - Acute effects of putative membrane estrogen receptors agonists and antagonists on male sexual motivation In Japanese Quail
PLENARY LECTURE
Galea L.A.M. (Canada) - Why sex and sex hormones matter for brain health: Steroid hormone modulation of cognition, emotion and hippocampal neuroplasticity
Chair: M.M. McCarthy (USA)
AGING
Chair: - L.M. Garcia-Segura (Spain) & M. Schumacher (France)
Urbanski H.F. (USA) - Regulation of neurosteroidogenesis in the nonhuman primate
Gibson G. (UK) - Progesterone and ischemia in ageing mice
Hogervorst E. (UK) Effects of gonadal hormones on cognitive behavior in aged men and women
Morrison J.H. (USA), Hao J., Hara Y., Dumitriu D., Wang A.C.J., Bailey M.E., Bloss E.B., Ohm D.T., Janssen W.G.M., Yuk F., Puri R., Baxter M.G., Rapp P.R. - Synaptic correlates of cognitive performance: Implications for cognitive aging and menopause
February 19
EPIGENETICS
Chair: M.M. McCarthy (Usa) & N. Mitro (Italy)
Frick K.M. (USA) - Epigenetic regulation of estrogen-induced memory enhancement
Bale T.L. (USA) - Prenatal stress reprogramming of offspring stress dysregulation: miRNA and placental contributions
Auger A.P. (USA) - Epigenetic organization of the juvenile social brain and sex-biased vulnerability to mental health disorders
McCarthy M.M. (USA), Nugent, B.M. Epigenetics of sex differentiation
ROUND TABLE
Effects of Finasteride treatment on the nervous system
Chair: R.C. Melcangi (Italy) & G.C. Panzica (Italy)
Speakers: Worthington A. (USA), Traish A.M. (USA), Melcangi R.C. (Italy), Bortolato M. (USA),
Walf A.A. (USA) & Frye C.A. (USA)
February 20
ESTROGEN-REGULATED SYNAPTIC CONNECTIVITY: NEW APPROACHES OF SIGNALING
Chair: J. Balthazart (Belgium) & G.M. Rune (Germany)
Kramár E. (USA) - Estrogens rapid influence on synaptic plasticity: interactions with integrins and actin cytoskeleton
Micevych P.E. (USA) - Membrane estrogen actions: mGluRs, spines and sexual receptivity.
Rune G.M. (Germany) Phosphorylation of aromatase by calcium-induced calcium release: implications for synaptic connectivity.
Abraham I.M. (N. Zealand) - Single molecule analysis of non-classical estradiol action in live neurons.
Zhang L. (Mexico), Hernández V. S. - Ovariectomy down-regulates the hypothalamic vasopressin PVN and SON volume, AVP/Aromatase co-expressing cell numbers and AVP fibres In amydgala and hippocampus: Its impact on anxiety and spatial learning
PLENARY LECTURE
Chair: G.C. Panzica (Italy)
Bourguignon J.-P. (Belgium), Franssen D., Gérard A., Lebrethon M.-C., Rasier G. and Parent A.-S. - Neuroendocrine disruption across reproduction and energy balance.
GENOMIC AND NON-GENOMIC EFFECTS OF NEUROACTIVE STEROIDS: MECHANISMS OF ACTION
Chair: J.J. Lambert (UK) & R.C. Melcangi (Italy)
Marin R. (Spain), Casañas V., Pérez J.A., Fabelo N., Fernandez C.E., Diaz M. - Membrane estrogen receptor as part of signalosomes in neurons. The concept of “lipid raft aging”.
Tetel M.J. (USA) - Nuclear receptor coactivators in steroid action in brain
Petersen S. (USA), Intlekofer K.A., Moura-Conlon P.J., Lopez J.A., del Pino J. - Non- classical progesterone signaling molecules in the nervous system
Levine J. (USA) - Consequences of non-classical ER alpha signaling in brain
Schütz G. (Germany), Berger S. - Dissection of glucocorticoid action in the brain using inducible gene inactivation
Kajta M. (Poland), Rzemieniec J., Litwa E., Wnuk A., Lason W., Nalepa I., Zelek-Molik A., Wojtowicz A. - Impact of G-Protein-coupled receptor 30 on the effects of daidzein and dichlorodiphenyltrichloroethane in mouse embryonic neuronal cells