SNS2009
5th INTERNATIONAL MEETING
STEROIDS AND NERVOUS SYSTEM
TORINO – Villa Gualino February 14-18 2009
February 14th SATELLITE SYMPOSIA
Satellite symposium
UNEXPECTED ACTIONS OF STEROID RECEPTORS REGULATING REPRODUCTIVE AND SOCIAL BEHAVIORS Organized by P.Micevych & J.Balthazart
Cornil A. C. (Belgium) Rapid behavioral effects of brain estrogens
Becker J. B. , Yang H., Hu M., Schultz K. M., Kennedy R. T. (USA) Estradiol receptor-alpha (er-alpha) and motivated behavior
Fusani L., Day L. B., Schlinger B. A. (Italy) Dynamic coupling and uncoupling between androgen and courtship behavior in male manakins
McCarthy M., Zhang J.-M., Krebs-Kraft D.L., Waddell J., Bowers J.M. (USA) A Novel Source of Sexual Dimorphism in the Mammalian Brain: Steroid Induced Cell Genesis
Meisel L. R. (USA) Nonlinear Approaches to Genomic Regulation of Female Sexual Behavio
Satellite symposium
GENDER-SPECIFIC THERAPEUTIC STRATEGIES BASED ON NEUROACTIVE STEROIDS: IN SEARCH FOR INNOVATIVE TOOLS FOR NEUROPROTECTION Organized by R.C.Melcangi & L.M. Garcia-Segura
Gillies G. E. (UK) Independent influences of sex steroids of systemic and central origin in a rat model of Parkinson's disease: a contribution to gender-specific neuroprotection by estrogen
Finn D., Tanchuck M.A., Fretwell A.M., Beckley E.H., Kaufman K.R., Ford M.M. (USA) Manipulation of GABAergic neurosteroids: Sex differences in the effects on alcohol drinking- and withdrawal-related behaviors
Paus T. (UK) The growt of white matter in the adolescent brain: role of testosterone and androgen
Frye C.A., Paris J.J., Freidenberg B.M., Franco C.A., Wulfert E. (USA) Gender differences in stress hormones in post traumatic stress disoreder and pathological gambling
Franklin R. J. (UK) Gender differences in CNS remyelination - a therapeutic opportunity?
Melcangi R.C., Pesaresi M., Maschi O., Giatti S., Caruso D. (Italy) Gender differences in neuroactive steroid levels: observations in diabetic neuropathy and encephalopathy.
February 15th
SEX DIFFERENCES IN, AND HORMONAL INFLUENCES ON, CANNABINOID-REGULATED BIOLOGY
(Chairs: McCarthy M. M., Wagner E. J.)
Wagner E. J. (USA) Sex differences in the cannabinoid regulation of energy homeostasis
Fratta W., Altea S., Fattore L. (Italy) Sex differences in the self-administration of cannabinoids
Viveros M. P. (Spain) Sex differences in developmental studies analyzing functional implications of the endocannabinoid system; interactions with stress and other drugs of abuse.
Franzoni M. F., Cottone E., Pomatto V., Guastalla A. (Italy) Role of the endocannabinoid system in the regulation of lower vertebrate reproduction
Main Lecture
Garcia-Segura L.M.(Spain) Estrogen and neuroprotection
(Chair: Melcangi R.C.)
STEROIDS AND PAIN (Chairs: Balthazart J., Mensah-Nyagan A.G.)
Mensah-Nyagan A. G., Meyer L., Schaeffer V., Kibaly C., Patte-Mensah C. (France) Steroids and Neurobiology of Pain: history, present and future
Jevtovic-Todorovic V. , Latham J.R., Pathirathna S., Jagodic M.M., Covey D.F., Todorovic S.M. (USA) T channel modulation with neuroactive steroid, ECN, relieves morbid-obesity-induced diabetic neuropathy in ob/ob mice
Aloisi A.M. , Fiorenzani P., Ceccarelli I. (Italy) Interactions between opioids and gonadal hormones in the modulation of pain
Marchand S., Gaumond I., Tousignant-Laflamme Y. (Canada) The Role of sex hormones on endogenous pain modulation: from animal to clinical research
Levine J. D. (USA) Pain is sexy
MaassenVanDenBrink A., de Vries R., ter Berg J.W.M. (The Netherlands) Hyperprolactinemia, female sex steroids and dopaminergic mechanisms with respect to the dopamine – prolactine axis in a patient with a hemicrania continua phenotype.
Round Table I:
Androgens and androgen receptors (Chairs: DonCarlos L., Mac Lusky N.)
DonCarlos, L.L. Sarkey, S. (USA) Rapid actions of androgens in the cerebral cortex
Collado P., Martini M., Di Sante G., Pinos H., Guillamon A., Panzica G.C.,(Spain) Role of androgens in masculinization of nitrergic system in rats
Rusmini P., Onesto E., Crippa V., Sau D., Bolzoni E., Galbiati R., Poletti A. (Italy) Pathophysiological roles of the androgen receptor in motor neurons
Rissman E.F. (USA) Role for androgen receptor in sexual differentiation
Paris J.J., Frye C.A. (USA) Formation of 3α-androstanediol may underlie alcohol-promoted aggression among rodents
Panzica G.C., Allieri, F., Bo, E., Collado P., Bakker J., Viglietti-Panzica C. (Italy) Androgens and development of the BST parvocellular vasopressin system
February 16th
IMPORTANCE OF CO-REGULATORY FACTORS FOR STEROID RECEPTOR ACTION IN THE BRAIN
(Chairs: Charlier T.D., de Vries G.J.)
Carruth L.L., Duncan, K. A. (USA) The estrogen alpha coactivator, RPL7, and sexual differentiation of the songbird brain
Tetel M.J. (USA) Nuclear receptor coactivators modulate hormone-dependent gene expression in brain and reproductive behavior in rodents
Auger A. (USA) Co-repressors and chromatin binding factors: the epigenetic organization of sex differences in the brain
Charlier T.D. (Belgium) Importance of steroid receptor coregulators for neuronal phenotype determination: modulation of steroid action.
Paramanik V., Thakur M.K. (India) Interaction of estrogen receptor associated protein (ERAP) 140 with estrogen receptor beta decreases during aging in mouse brain
Main Lecture
Anne M Etgen (USA) Intracellular signal transduction cascades mediating the behavioral actions of estrogens( Chair: Panzica G.C.)
ESTROGEN-INDUCED NON-CLASSICAL SIGNALING IN THE BRAIN: MECHANISM AND ROLE
(Chairs: Abraham I., Bakker J.)
Rune G. (Germany) The maintenance of mature dendritic hippocampal spines requires rapid estrogen signaling
Michevych P., Bondar G., Kuo J., Dominguez R. (USA) Estradiol regulation of membrane estrogen receptor and its role in reproduction
McMahon L., Smith C.C., Vedder L.C., (USA) Estrogen, NR2b containing NMDA receptors, and LTP at hippocampal synapses
Abraham I., Zsombor Kőszegi, Éva M Szegő (New Zealand) Mechanism and role of rapid estrogen signaling in basal forebrain cholinergic neurons
Vegeto E., Maggi A. (Italy) Estrogen and brain inflammation
Cambiasso M.J., Gorosito S.V. (Argentina) An estrogen receptorα variant located at the cell- surface of hypothalamic neurons is regulated by estradiol
February 17
VITAMIN D THE FORGOTTEN NEUROSTEROID (Chairs: Eyles D.W., Melcangi R.C.)
Eyles D. W., Burne T, Cui X., Kesby J., Harms L., Ko P., Pelekanos M., McGrath J.J. (Australia) Developmental vitamin D deficiency causes abnormal brain development
Feron F., Fernandes de Abreu D.A., (France) Vitamin D, a neuro-immunomodulator. Implications for auto-immune and neurodegenerative diseases
Tuohimaa P., Kalueff A., Keisala T., Minasyan A. (USA) Vitamin D, nervous system and aging
Grecksch G., Rüthrich H., Höllt V. and Becker A. (Germany) Transient prenatal vitamin d deficiency is associated with changes of synaptic plasticity in the dentate gyrus in adult rats
Round table II:
Neurosteroids and pregnancy: long term effects on development (Chair: Hirst J.)
Brunton P.J., Russell J.A. (UK) Opioid inhibition of hypothalamo-pituitary-adrenal (HPA) axis stress responses in pregnancy is induced by allopregnanolone
Grattan D. R. (NZ) Gonadal steroid modulation of cytokine action in the brain during pregnancy
Hill M., Pařízek A. (Czech Rep) Biosynthesis and transport of neuroactive steroids in pregnancy
Matthews S. G. (Canada) Glucocorticoids and transgenerational programming of neuroendocrine function and behaviour
Biggio G., Murru L., Sanna E., Mostallino M.C. (Italy) Changes in BDNF, Arc and Long-Term Potentiation in the Rat Brain during Pregnancy and after Post-Partum
Penn A.A., Ermini F., Morgan A.C.A. (USA) Progesterone promotes neural progenitor proliferation in embryonic cortex
Hirst J.J., McKendry A.A., Kelleher M.A., Walker D.W., Palliser H.K. (Australia) Neurosteroid synthesis in compromised pregnancies: role in neuroprotection.
Luciano Martini Prize Lecture
A.A. Walf (USA) The trophic effects of estradiol and SERMS in the hippocampus and peripheral tissues
February 18th
NEUROSTEROIDS AND GABA-A RECEPTORS (Chairs: Maguire J., Smith S. S.)
Mennerick S., Akk G., Covey D.F., Evers A.S., Steinbach J.H., Zorumski C.F., (USA) The importance of membrane interactions to neuroactive steroid effects at GABAa receptors
Zheleznova N., Sedelnikova A., Weiss D.S. (USA) α1β2δ, a silent GABAa receptor: recruitment by tracazolate and neurosteroids
Smith S. S., Aoki C. and Shen H. (USA) Reversal of neurosteroid effects at GABAa receptor triggers anxiety at puberty in female mice
Maguire J., Mody I. (USA) Endogenous steroid hormone-mediated changes in GABAa receptors alter neuronal excitability
Biggio G., Mostallino M.C., Sanna E. (Italy) Plasticity and function of extrasynaptic GABAa receptors during pregnancy and after delivery
Frye, C.A., Llaneza, D.C., Paris, J.J. (USA) Activational and organizational effects of progesterone for affective and cognitive behavior due to 5α-pregnan-3α-ol-20-one
Main Lecture
J.J. Lambert (UK) Neurosteroids: neuron specific allosteric modulators of the GABAA receptor
(Chair: Mensah-Nyagan G.)
PATHOGENETIC MECHANISMS MEDIATED BY GLUCOCORTICOID RECEPTORS IN PSYCHIATRIC DISORDERS: FROM BENCH TO CLINICS (Chairs: Gass P., Pariante C.M.)
Pariante C. M. (UK) Modulation of the glucocorticoid receptor by antidepressants
Tronche F. (France) Inactivation of the glucocorticoid receptor gene in targeted neuronal populations: new insights on addiction and emotional behaviours
Binder E.B. (USA) The role of the glucorticoid receptor and its co-chaperones in pathogenesis and therapy of affective disorders
Ferrier N.I. (UK) Glucocorticoid receptor antagonists in major depression – a new therapeutic avenue?
Berry A., Carnevale D., Giorgio M., Pelicci P.G., de Kloet E.R., Alleva E., Minghetti L., Cirulli F. (Italy) Greater resistance to psychophysical stress in p66Shc-/- mice, a model of delayed and healthy aging