SNS2011
6th INTERNATIONAL MEETING
STEROIDS AND NERVOUS SYSTEM
TORINO – Villa Gualino February 19-23, 2011
February 19
Satellite Symposium
Neuroactive steroids: focus on human brain
(Organizers: Melcangi R.C., Panzica G.C., Garcia-Segura L.M.)
Azcoitia I. Yague J., Veiga S. and García-Segura L.M. (Spain) Estradiol synthesis within the human brain
Pike C.J. (USA) Sex steroid hormone levels in aging brain and their relationships with Alzheimer’s disease
Peri A. (Italy) Membrane cholesterol as a mediator of the neuroprotective effects of estrogen
van Wingen G.A., Ossewaarde L., Bäckström T., Hermans E.J. (Netherlands) Gonadal hormone regulation of the affective neurocircuitry in humans
Peper J.S., Hulshoff Pol H.E., Crone E.A., van Honk J. (Netherlands) Sex steroids and brain structure in pubertal boys and girls
Bayer U., Hausmann M. (UK) Sex hormone therapy and functional brain plasticity in postmenopausal women
Bäckström T., Haage D., Löfgren M., Johansson I.M., Strömberg J., Nyberg S., Andreen L., Björn I., Bengtsson S.K., Lundgren P. (Sweden) Paradoxical effects of GABAa modulators may explain sex steroid induced negative mood symptoms in certain persons
Marx C.E. (USA) Pregnenolone as a novel therapeutic candidate in schizophrenia: preclinical and clinical evidence
Stein D.G. (USA) An update on progesterone and its metabolites in the treatment of traumatic brain injury and other CNS disorders
February 19
Opening Lecture:
Schlinger B.A. (USA) Neurosteroidogenesis: a comparative and functional point of view
(Chair: Herbison A.)
February 20
Neuroprotective effects of neuroactive steroids (Chairs: Stein D.G., Pike C.J.)
Brann D.W., Wang R., Raz L., Vadlamudi R.K., Yang F., and Zhang Q.G. (USA) Estradiol neuroprotection in cerebral ischemia – role of extranuclear estrogen receptors and NADPH oxidase modulation and effect of long-term estrogen deprivation
Al Sweidi S., Bourque M., Sanchez M. G., Morissette M., Dluzen D. and Di Paolo T. (Canada) Neuroprotective effects of sex steroids in Parkinson's disease: estrogen receptors and signaling pathways implicated
Beyer C. (Germany) Sex steroids modulate local inflammatory processes and protect myelination in experimentally-demyelinated mice
Spence R.D., Hamby M.E., Umeda E., Itoh N., Du S., Bondar G., Lam J., Ao Y., Wisdom A., Cao Y., Sandoval F., Sofroniew M.V., Voskuhl R.R. (USA) Neuroprotective effects of estrogen in multiple sclerosis
Fleiss B., Parkington H.A., Coleman H.A., Castillo-Melendez M., Hirst J.J., Walker D.W. (Australia) Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse
Hampl R., Hill M., Bičíková M. (Czech Republic) Steroids, schizophrenia and Alzheimer disease – what they have in common
Plenary Lecture:
Brinton R.D. (USA) Estrogen-induced plasticity from cells to circuits: predictions for cognitive function
(Chair: Garcia-Segura L.M.)
Pharmacological tools related to neuroactive steroids
(Chairs: Melcangi R.C., Zheng P.)
Schumacher M., Girard C., Adams D., and Schweizer-Groyer G. (France) Axonal regeneration and neuroinflammation: roles for the translocator protein (TSPO)
Rupprecht R. (Germany) Translocator protein (18 kDa) as target for anxiolytics without benzodiazepine-like side effects
Papadopoulos V., and Lecanu L. (Canada) Neurosteroid pharmacology: caprospinol turning the tide on Alzheimer’s drug development
Pinna G. (USA) SSRIs act as selective brain steroidogenic stimulants (SBSSs): insight into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders
Zheng P. (China) Neurosteroid dehydroepiandrosterone sulphate enhances glutamate release through activation of dopamine D1 and sigma-1 receptor
Bortolato M., Frau R., Bini V., Pillolla G., Paba S., Marrosu F., and Devoto P. (USA) Therapeutic properties of steroid 5-alpha reductase inhibitors in neuropsychiatric disorders: from bench to bedside
Cermenati G., Giatti S., Maschi O., Abbiati F., Brioschi E., Cavaletti G., Bianchi R., Pesaresi M., Volonterio A., Saez E., Melcangi R.C., Caruso D. and Mitro N. (Italy) Liver x receptors activation ameliorate diabetic peripheral neuropathy increasing locally neuroactive steroid levels
February 21
Steroids and GnRH System
(Chairs: Herbison A., Melcangi R.C.)
Moenter S.M. ( USA) Rapid non-genomic effects of oestradiol on GnRH neurons
Rønnekleiv O.K., Zhang C., Bosch M.A., and Kelly M.J. (USA) Estradiol regulation of T-type calcium channels in GnRH neurons
Clarkson J., and Herbison A.E. (New Zeland) Estradiol regulation of kisspeptin neurons during pubertal development
Kauffman A.S. (USA) Circadian and hormonal regulation of neural reproductive circuits
Taziaux M., Swaab D.F., and Bakker J. (The Netherlands) Neurokinin B in the human infundibular nucleus: sex difference and developmental aspects
Tolson K.P., Tonsfeldt K.J., Goodall C.P., Palermini A., and Chappell P.E. (USA) Disruption of endogenous circadian clocks in immortalized GT1-7 cells blocks estrogen positive feedback-stimulated GnRHsecretion in vitro
Plenary Lecture:
Tena-Sempere M. (Spain) Sex steroids and the control of kisspeptin system
(Chair: Motta M.)
Luciano Martini Prize Lecture
Martini M. (Italy) Gonadal hormones regulation of nitrergic system
Round Table
Endocrine disrupter action on behavior and neuroendocrine systems
(Chairs: Frye C.A., Panzica G.C.)
Venerosi A., Tait S., Ricceri L., Stecca L., Mantovani A., and Calamandrei G. (Italy) Dietary exposure to a non-persistent insecticide targets permanently neuroendocrine pathways and sex-dimorphic social response in a mouse model of neurodevelopmental disorder
Fernandez M., Alessandri M., Paradisi M., Lorenzini L., Sivilia S., Giuliani A., Giardino L., and Calzà L. (Italy) Effects of prenatal 2,3,7,8-tetrachlorodibenzo-p-dioxin exposition on central nervous system developmental myelination and thyroid hormone status
Bo E., Miceli D., Rodriguez Gomez A., and Panzica G.C. (Italy) Bisphenol A and genistein alter social and explorative behaviours in CD1 mice
Fusani L., Farabollini F., Della Seta D., and Dessì-Fulgheri F. (Italy) Environmental-like exposure of rats to xenoestrogen: effects on juvenile brain and behavior
Patisaul H.B., and Losa S.M. (USA) Endocrine disruption of sexually dimorphic neuroendocrine pathways in the peripubertal rat brain
Kah O., Le Page Y., Vosges M., Tong S.-K., Chung B.-c. and Brion F. (France) Aromatase-expressing radial progenitor cells are direct targets for endocrine disruptors in zebrafish
February 22
ER beta - where have we got to?
(Chairs: : Kelly , Bakker J.)
Handa R.J., Sharma D., Uht R., and Mani S.K. (USA) Functional roles for estrogen receptor beta in mediating the actions of androgen metabolites
Wang J.M., and Brinton R.D. (USA) ERb and neural progenitor cell proliferation
Ogawa S. (Japan) The role of estrogen receptor beta in the regulation of social and emotional behavior
Herbison A.E., Cheong R., Porteous R., Ábrahám I.M. (New Zealand) A role for estrogen receptor beta in GnRH neurons?
Steroids and neuroimmunomodulation
(Chairs: Brinton R.D., Garcia-Segura L.M.)
Deak T., Hueston C.M., and Blandino Jr. P. (USA) The complex interplay between stress responsive systems and neuroinflammation
Brunton P.J. and Russell J.A. (UK) Inhibition of neuroendocrine stress responses to immune challenge in pregnancy is induced by allopregnanolone
Reichardt H.M. (Germany) Glucocorticoids in the control of neuroinflammation
Arevalo M.A., Diz-Chaves Y., Santos-Galindo M., Bellini M.J., and García-Segura L.M. (Spain) Selective estrogen receptor modulators decrease inflammatory response of glial cells
Quennell J.H., Augustine R.A., Khant Aung. Z., Bunn S.J., and Anderson G.M. (New Zealand) Estrogens: new regulators of brain SOCS
February 23
Alternative signalling mechanisms of neuroactive steroids in nervous system
(Chairs: Mani S., Lambert J.)
Garcia-Segura L.M., Azcoitia I., Arevalo M.A. (Spain) Interactions of estradiol, IGF-1 and Wnt signalling in the nervous system
Simoncini T. (Italy) Rapid signaling of estrogen and spine formation via the actin cytoskeleton
Oberlander J.G., Penatti C.A.A., Porter D.M., and Henderson L.P. (USA) Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in the mammalian forebrain
Santoru F., Berretti R., Sogliano C., Calza A., Dazzi L., and Concas A. (Italy) Changes in neuroactive steroid levels, GABAA receptor plasticity and sensitivity to anxiolytic drugs induced by neonatal exposure to estrogen
Kajta M., LasonW., Litwa E., Rzemieniec J., and Wojtowicz A.K. (Poland) Dichlorodiphenyltrichloroethane (DDT)-induced apoptosis of embryonic neuronal cells: an involvement of G-protein-coupled receptor 30 and glycogen synthase kinase-3b intracellular signaling
Steroid hormones and brain sex dimorphism: Experimental murine models
(Chairs: Panzica G.C., Balthazart J.)
Brock O., and Bakker J. (Belgium) A role for ovarian hormones in the sexual differentiation of the female brain?
Büdefeld T., Grgurevic N., Spanic T., Tobet S.A. and Majdic G. (Slovenia) Brain sex differentiation in agonadal steroidogenic factor 1 knockout mice
Arnold A.P. (USA) Sex chromosome effects that explain sex differences in phenotype: what’s the next step?
Frye C.A. (USA) Pregnane xenobiotic receptors in the ventral tegmental area may mediate progestogen-facilitated reproductive behavior of female rats
Marchetti B., L’Episcopo F., Tirolo C., Testa N., Caniglia S., Panzica G.C., and Morale M.C. (Italy) Gender difference in the response of adult subventricular zone (SVZ) neuroprogenitors in a mouse model of Parkinson’ disease: critical role of estrogen