SNS2015
8th International Meeting
STEROIDS and NERVOUS SYSTEM
TORINO - February 14-18, 2015
SATURDAY 14
Satellite Symposium: GENDER INFLUENCE ON NEURODEGENERATIVE AND PSYCHIATRIC DISORDERS
Melcangi R.C. (Italy) Sex dimorphic levels of neuroactive steroids in physiological and pathological nervous system
Litim N., Bourque M., Morissette M., Di Paolo T. (Canada) Sex differences in Parkinson: different neuroprotective effect of sex steroids
Pike C.J., Christensen A., Moser V.A. (USA) Obesity and Alzheimer's disease: gender differences and sex steroid hormones
Eckert A. (Switzerland) Alzheimer, mitochondria and gender
Gold S.M. (Germany) Sex effects on inflammatory and neurodegenerative processes in autoimmunity
Kipp M., Beyer C. (Germany) Placenta-derived factors as possible immunosuppressive agents in autoimmune inflammatory brain disorders
Gibson C.L. (UK) The impact of gender on cerebral stroke pathology and treatment
Mendrek A. (Canada) Sex/gender differences in the neurocognitive function in schizophrenia
1Du X., Wu Y.W.C., van den Buuse M., Hill R.A. (Australia) A role for sex steroid hormones in the regulation of behaviours with relevance to schizophrenia
General discussion and Closure of the Satellite Symposium
REGULAR MEETING
SATURDAY 14
OPENING LECTURE
Balthazart J. (Belgium)
Is research on organizational effects of steroids translational? The case of human sexual orientation
Chair: García-Segura L.M.
SUNDAY 15 - San Luigi Hospital - Orbassano
CURRENT PERSPECTIVES ON NEUROBEHAVIORAL SEXUAL DIMORPHISMS
Chair: Wagner E. and Panzica G.C.
De Vries G.J. (USA) Sexual differentiation of the brain seen from a whole-body perspective
Panzica G.C., Bo E., Martini, M., Miceli D., Mura E., Rodriguez-Gomez A., Gotti S. (Italy) Sexually dimorphic effects of endocrine disruptors on brain and behavior
Shah N (USA) Modular genetic and neural control of social behaviors
Rivas V.M., Vargas A., Meza C., Kachani M., Wagner E.J. (USA) Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis
PLENARY LECTURE
Rae Silver (USA)
Sex differences in circadian timing system: why we care
Chair: J. Balthazart
STRESS IN PREGNANCY: LONG-TERM EFFECTS ON STEROID PATHWAYS.
Chair: Hirst J., Walker D.
Reynolds R.M. (UK) Stress in pregnancy: long-term effects on steroid pathways
Donadio M.V., Lai Y., Yao S.T., Greenwood M., Murphy D., Russell J.A., Brunton P.J. (UK) Stress during pregnancy: sex-dependent effects on steroid pathways in the offspring brain
Hirst J.J., Walker D.W., Bennett G.A., Cumberland A.L., Shaw J.C., Palliser H.K. (Australia) Loss of steroid-mediated neuroprotection following stress in fetal life
Walker D.W., Quinn T.A., Ratnayake U., Dickinson H., Castillo-Melendez M. (Australia) The feto-placental unit revisited – the role of the fetal adrenal gland, brain, and placenta in provision of the androgen DHEA to protect the developing brain
Matthews S.G. (Canada) Glucocorticoid programming of stress pathways: a transgenerational perspective
MONDAY 16
NEUROLOGICAL CONSEQUENCES OF DISORDERED STEROID SIGNALING
Chair: Balthazart J., Melcangi R.C.
Patisaul H.B. (USA) Rewired: endocrine disruption of sexually dimorphic neuroendocrine signaling pathways
Campbell R.E., Prescott M., Marshall C., Yip S.-H., Moore A.M. (New Zealand) Disrupted progesterone signaling in the neuroendocrine genesis of polycystic ovarian syndrome
Maguire J. (USA) Peripartum changes in gabaergic control of the hippocampus and HPA axis: implications for maternal mood
Giatti S., Foglio B., Romano S., Garcia-Segura L.M., Panzica G.C., Caruso D., Melcangi R.C. (Italy) Effect of finasteride treatment in male rat nervous system
Bortolato M., Godar S.C., Mosher L., Pes R., Frau R., Devoto P. (USA) Role of neurosteroids in the pathophysiology of Tourette syndrome and pathological gambling
PLENARY LECTURE
Schumacher M. (France)
Neuroprotective effects of steroids
Chair: Melcangi R.C.
NEUROACTIVE STEROIDS AND GLIAL CELLS
Chair: Garcia-Segura L.M., Mensah-Nyagan A.G.
Garcia-Segura L.M., Arevalo M.A., Azcoitia I., Ruiz-Palmero I., Lopez-Rodriguez A.B., Acaz-Fonseca E. (Spain) Estrogenic regulation of reactive gliosis
Pellegrini E., Diotel N., Vaillant-Capitaine C., Pérez R., Gueguen M., Cano Nicolau J., Cruciani C., Nasri A., Kah O. (France) Steroid modulation of neurogenesis: focus on radial glial cells in zebrafish
Khalaj A.J., Moore S., Hasselmann J., Katzenellenbogenand J.A., Tiwari-Woodruff S.K. (USA) Nudging oligodendrocyte intrinsic signaling to remyelinate and repair: estrogen receptor ligand effects
Bilbo S.D. (USA) Sex differences in developing hippocampal microglia of mice: relevance for neurodevelopmental disorders
Nicot A.B., Guillot F., Garcia A., Salou M., Brouard S., Laplaud D.A. (France) Expression of gene transcripts involved in steroid metabolism from laser-captured mouse white matter astrocytes
Mitro N., Cermenati G., Audano M., Giatti S., Azcoitia I., Garcia-Segura L.M., Melcangi R.C., Caruso D. (Italy) A new pathway to exert protective effects on diabetes peripheral neuropathy: role of neuroactive steroids on myelin lipid profile
TUESDAY 17
GABA-A RECEPTOR MODULATING STEROID ANTAGONISTS (GAMSA). A NEW TREATMENT CONCEPT FOR CNS DISORDERS.
Chair: Backstrom T. (Sweden), Brunton P. (UK)
Strömberg J., Malinina E., Johansson M., Ragagnin G., Haage D., Lundgren P., Wang M., Taube M., Bäckström T. (Sweden) GABAA receptor modulating steroid antagonist (GAMSA)
Johansson M., Turkmen S., Strömberg J., Ragagnin G., Malinina E., Haage D., Öfverman C., Lundgren P., Birzniece V., Zingmark E., Bäckström T. (Sweden) Antagonism of allopregnanolone-induced learning and memory disturbance by GAMSA
Butterworth R.F. (Canada) Neurosteroids in hepatic encephalopathy
Agusti A., Llansola M., Hernández-Rabaza V., Montoliu. C, Felipo V. (Spain) Modulation of GABAA receptors by steroids. A new concept to improve cognitive and motor alterations in hepatic encephalopathy
ROUND TABLE - NEUROSTEROIDOGENESIS TODAY
(sponsorised by Journal of Neuroendocrinology)
Chair: Melcangi R.C., Panzica G.C.
Porcu P., Cook J.B., Werner D.F., Maldonado-Devincci A.M., Leonard M.N., Fisher K.R., O’Buckley T.K., McCown T.J., Besheer J., Hodge C.W., Morrow A.L. (USA) Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3A,5A-THP and reduces long-term operant ethanol self-administration
Yang S.-Y., He X.-Y., Isaacs C., Dobkin C., Miller D., Philipp M. (USA) Roles of 17b-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorder
Barron A.M., Asih P. , Ji B. , Suhara T. , Pike, C.J., Katsifis A., Martins R.N., Higuchi M. (Japan) Translocator protein as a therapeutic target for Alzheimer`s disease
Koonce C.J., Rusconi J.C., Walf A.A., Drew K., Frye C.A. (USA) Progesterone enhances and pregnane xenobiotic receptor deletion attenuates exploratory, anxiety and social behaviors in female rats
YOUNG INVESTIGATOR Symposium
Chair: Frye C.A., Mensah-Nyagan A.G.
Lopez-Rodriguez A.B., Acaz-Fonseca E., Viveros M.P., Garcia-Segura L.M. (Spain) Molecular changes in the brain of male and female mice after traumatic injury: association with brain edema and neurological deficit
Acaz-Fonseca E., Duran J., Carrero P., Arevalo M.A. Garcia-Segura L.M. (Spain) Sex differences in glia reactivity after cortical brain injury
Yawno T., Fahey M.C., Aridas J., Miller S.L., Walker D.W. (Australia) New approaches to treatment of neonatal seizures
Cumberland A.L., Palliser H.K., Hirst J.J. (Australia) Female juvenile guinea pigs display increased anxiety-like phenotype following reduced allopregnanolone exposure in utero
Grimm A., Mensah-Nyagan A.G., Eckert A. (France) Mitochondrial dysfunction in Alzheimer's disease: insights into neuroprotective effects of neurosteroids
Nuzzo M.T., Fiocchetti M., Ascenzi P., Marino M. (Italy) Estrogen effect in neuroprotection and neurodegeneration relies on HTT-NGB association
WEDNESDAY 18
LOCALLY DERIVED ESTRADIOL IN THE PREFRONTAL CORTEX AND HIPPOCAMPUS ENHANCES MEMORY AND BLOCKS DELETERIOUS EFFECTS OF STRESS
Chair: Balthazart J., Luine V.
Rune G.M. (Germany) Aromatase inhibition abolishes LTP generation in female but not in male mice
Luine V. (USA) Estradiol rapidly enhances memory, increases dendritic spines and protects against stress-induced memory impairments
Gall C.M., Kramár E.A., Lynch G. (USA) Estradiol collaborates with other synaptic modulatory receptors in the regulation of glutamatergic transmission
Zhen Y. (USA) (presented by Popoli M.) Local estradiol synthesis and action in the prefrontal cortex blocks stress-induced impairments in recognition memory in female rats
Ruiz-Palmero I., Garcia-Segura L.M., Arevalo M.-A. (Spain) Neuritogenesis and its regulation by estradiol are sexually dimorphic in primary mouse hippocampal neurons
Yamazaki T., Ishihara Y., Yamamoto M. (Japan) Neuroprotection by de novo synthesized estradiol and brain-converted allopregnanolone in cultured rat hippocampus
Special Lecture:
Monique Vallee (France)
A novel therapeutic potential for neurosteroids: focus on pregnenolone and CB1-mediated cannabinoid functions
Chair: Melcangi R.C.
COULD MEN AND WOMEN UNDERGOING (EARLY) MENOPAUSE BENEFIT FROM SPECIFIC PHYTOESTROGENIC PRODUCTS TO REDUCE LATER LIFE DEMENTIA RISK?
Chair: Hogervorst E. and Rahardjo, T.
Rocca W.A. (USA) Oophorectomy, early menopause, estrogen, and dementia: a 2015 update
Irsan A.K., Hardinsyah, Winarno A., Rahardjo T.B., Hogervorst E. (Indonesia) Tempe reversed the effects of ovariectomy on brain function in ovx rats: effects of age and type of soy product
Soni M., White L. R., Bandelow S., Launer L., and Hogervorst E (UK) Food for thought: does tofu interact with thyroid function to effect cognition in elderly populations?
Hogervorst E Xu Xin, Mira Soni, Atik Kridawati, Xiao Shifu, Tri Budi Rahardjo (UK, China, Indonesia) Phyoestrogens, menopause and dementia risk: present and future