Immunological synapse

An interface between a T cell and an antigen-presenting cell, in which the molecular machinery for antigen presentation and T cell activation is present. One of the most important functions of the immunological synapse is an integration of innate and adaptive signals to decide if the initiation of an immune response or an effector program is appropriate following specific antigen recognition. 

Immune Checkpoint Molecules

Immune checkpoint molecules (ICM) are regulators and co-stimulatory receptors of the immune system. Recently, James P. Allison and Tasuku Honjo were awarded the Nobel Prize in Physiology or Medicine in 2018 for cancer immunotherapy. ICMs as play an important role in several immune responses could be of special interest.