-Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

-Microglia mediated by LAG3 regulate astrocyte morphogenesis in the brain white matter

-Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

-Obesity induces PD-1 on macrophages to suppress anti-tumour immunity

-The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis

-CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma

-Innate PD-L1 limits T cell–mediated adipose tissue inflammation and ameliorates diet-induced obesity

-The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

-Siglec-9 acts as an immune-checkpoint

molecule on macrophages in glioblastoma,

restricting T-cell priming and immunotherapy

response

-Inhibitory co-receptor Lag3 supports Foxp3+

regulatory T cell function by restraining Mycdependent

metabolic programming

-Steatosis drives monocyte-derived macrophage

accumulation in human metabolic dysfunctionassociated

fatty liver disease

-Lipid-Associated Macrophages Control Metabolic

Homeostasis in a Trem2-Dependent Manner

-Neuroplasticity therapy using glia-like cells

derived from human mesenchymal stem cells

for the recovery of cerebral infarction sequelae

-Microglia and their LAG3 checkpoint underlie the

antidepressant and neurogenesis-enhancing effects of

electroconvulsive stimulation

-Dectin-1 plays a deleterious role in high fat diet-induced

NAFLD of mice through enhancing macrophage activation

-Mechanistic convergence of the TIGIT and PD-1

inhibitory pathways necessitates co-blockade to

optimize anti-tumor CD8+ T cell responses

-Hypoxia coordinates the spatial landscape of myeloid

cells within glioblastoma to affect survival

-Oncogene-induced TIM-3 ligand expression dictates susceptibility to anti–TIM-3 therapy in mice

-TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

-Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

-Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

-A subset of Kupffer cells regulates metabolism through the expression of CD36

-Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas

-Krüppel-like factor 4 regulates the cytolytic effector function of exhausted CD8 T cells

-TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

-Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain

-Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells

-YTHDF2 orchestrates tumor-associated macrophage reprogramming and controls antitumor immunity through CD8+ T cells

-PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype

-Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells

-SLAMF6 as a Regulator of Exhausted CD8þ T Cells in Cancer

-In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue

-Monocyte-derived alveolar macrophages autonomously determine severe outcome of respiratory viral infection

-A MyD88/IL1R Axis Regulates PD-1 Expression on Tumor-Associated Macrophages and Sustains Their Immunosuppressive Function in Melanoma

-Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stemlike CD8+ T Cells during Chronic Infection

-CD11b immunophenotyping identifies inflammatory profiles in the mouse and human lungs

-RNF219/𝜶-Catenin/LGALS3 Axis Promotes Hepatocellular Carcinoma Bone Metastasis and Associated Skeletal Complications

-CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity

-Chitinase-3-like 1 protein complexes modulate macrophagemediated immune suppression in glioblastoma

-CHI3L1 regulates PD-L1 and anti-CHI3L1-PD-1 antibody elicits synergistic antitumor responses

-Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment

-Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity

-Single-cell transcriptome analysis reveals TOX as a promoting factor for T cell exhaustion and a predictor for anti-PD-1 responses in human cancer