RESEARCH
CAR T-cell
RESEARCH
CAR T-cell
Nature Cancer 2, 780-793 (2021)
https://doi.org/10.1038/s43018-021-00241-5
CAR T-cell
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary improvement in customized cancer treatment. CAR T-cells are made by collecting T cells from the patient and engineered in the laboratory to be commensurate with chimeric antigen receptors.
Nature Review Clinical Oncology 19, 755-790 (2022)
https://doi.org/10.1038/s41571-022-00689-z
The strategy of CAR T-cell
CAR T-cells are modulated receptors that consist of four main components; antigen binding domain, hinge region, transmembrane domain, and intracellular signaling domains