2024
Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. Ferroptosis in health and disease. Redox Biol. 2024 May 30;75:103211. doi: 10.1016/j.redox.2024.103211. Epub ahead of print. PMID: 38908072.
Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H. PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. Nat Metab. 2024 May 31. doi: 10.1038/s42255-024-01053-4. Epub ahead of print. PMID: 38822028.
河口まどか、本橋ほづみ．環境ストレス応答と硫黄代謝． 臨床免疫・アレルギー科 81(4)、396-402、2024.
Hayashi M, Okazaki K, Papagiannakopoulos T*, Motohashi H*. The complex roles of redox and antioxidant biology in cancer. Cold Spring Harb Perspect Med. 2024 May 21:a041546. doi: 10.1101/cshperspect.a041546. Epub ahead of print. PMID: 38772703.
Sekine H, Motohashi H. Unique and overlapping roles of NRF2 and NRF1 in transcriptional regulation. J Clin Biochem Nutr. 2024 Mar;74(2):91-96. doi: 10.3164/jcbn.23-106.
Nishimura A, Yoon S, Matsunaga T, Ida T, Jung M, Ogata S, Morita M, Yoshitake J, Unno Y, Barayeu U, Takata T, Takagi H, Motohashi H, van der Vliet A, Akaike T. Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality. Redox Biol. 2024 Feb;69:103018. doi: 10.1016/j.redox.2023.103018.
Hayasaka K, Takeda H, Sakurada A, Matsumura Y, Abe J, Shiono S, Notsuda H, Suzuki H, Endo M, Motohashi H, Okada Y. Clinical, Genomic, and Transcriptomic Featurses of Lung Adenocarcinoma With Uncommon EGFR Mutation. Clin Lung Cancer. 2024 Jan;25(1):e43-e51. doi: 10.1016/j.cllc.2023.10.006.
2023
Alam MM, Kishino A, Sung E, Sekine H, Abe T, Murakami S, Akaike T*, Motohashi H*. Contribution of NRF2 to Sulfur Metabolism and Mitochondrial Activity. Redox Biol 60, 102624, 2023. doi: 10.1016/j.redox.2023.102624. (*co-correspondence)
Takeda H, Nakajima Y, Yamaguchi T, Watanabe I, Miyoshi S, Nagashio K, Sekine H, Motohashi H, Yano H, Tanaka J. The anti-inflammatory and anti-oxidative effect of a classical hypnotic bromovalerylurea mediated by the activation of NRF2. J Biochem mvad030, 2023. doi: 10.1093/jb/mvad030.
Zainol Abidin QH, Ida T, Morita M, Matsunaga T, Nishimura A, Jung M, Hassan N, Takata T, Ishii I, Kruger W, Wang R, Motohashi H, Tsutsui M, Akaike T. Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism. Antioxidants (Basel) 12(4), 868, 2023. doi: 10.3390/antiox12040868.
Ikeda R, Noshiro D, Morishita H, Takada S, Kageyama S, Fujioka Y, Funakoshi T, Komatsu-Hirota S, Arai R, Ryzhii E, Abe M, Koga T, Motohashi H, Nakao M, Sakimura K, Horii A, Waguri S, Ichimura Y, Noda NN, Komatsu M. Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response. EMBO J. 2023 Jul 17;42(14):e113349. doi: 10.15252/embj.2022113349.
Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, Numakura T, Ida T, Jung M, Ogata S, Yoon S, Fujino N, Kyogoku Y, Sasaki Y, Koarai A, Tamada T, Toyama A, Nakabayashi T, Kageyama L, Kyuwa S, Inaba K, Watanabe S, Nagy P, Sawa T, Oshiumi H, Ichinose M, Yamada M, Sugiura H, Wei FY, Motohashi H*, Akaike T*. Supersulphides provide airway protection in viral and chronic lung diseases. Nat Commun. 2023 Jul 25;14(1):4476. doi: 10.1038/s41467-023-40182-4. (*co-correspondence)
Takeda H, Murakami S, Liu Z, Sawa T, Takahashi M, Izumi Y, Bamba T, Sato H, Akaike T, Sekine H, Motohashi H*. Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop. Redox Biol. 2023 Jul 29;65:102834. doi: 10.1016/j.redox.2023.102834.
Kasamatsu S, Nishimura A, Alam MM, Morita M, Shimoda K, Matsunaga T, Jung M, Ogata S, Barayeu U, Ida T, Nishida M, Nishimura A, Motohashi H*, Akaike T*. Supersulfide catalysis for nitric oxide and aldehyde metabolism. Sci Adv. 2023 Aug 18;9(33):eadg8631. doi: 10.1126/sciadv.adg8631. (*co-correspondence)
Hayasaka K, Ohkouchi S, Saito-Koyama R, Suzuki Y, Okazaki K, Sekine H, Watanabe T, Motohashi H*, Okada Y*. Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response. Am J Transplant. 2023 Sep 19:S1600-6135(23)00692-5. (*co-correspondence)
本橋ほづみ．環境化学物質に対する生体応答を担う転写制御．特集「環境科学物質と生体応答」Medical Science Digest 49 (1), 677-680, 2023.
村上昌平、成恩圭、本橋ほづみ．NRF2活性化による抗老化作用に関わる分子機構．特集「抗老化医療の、未来をさぐる：哺乳類における老化・寿命制御の理解とその社会実装」 老年医学 61(1)、55-61、2023.
草野佑典、村上昌平、本橋ほづみ．エネルギー代謝におけるKEAP1-NRF2制御系と硫黄代謝の役割．化学と生物61 (4), 188-195, 2023.
Murakami S, Kusano Y, Okazaki K, Akaike T, Motohashi H. NRF2 signalling in cytoprotection and metabolism. Br J Pharmacol. 2023 Sep 15. doi: 10.1111/bph.16246. Epub ahead of print. PMID: 37715470.
Barayeu U, Sawa T, Nishida M, Wei FY, Motohashi H, Akaike T. Supersulfide biology and translational medicine for disease control. Br J Pharmacol. 2023 Oct 23. doi: 10.1111/bph.16271. Epub ahead of print. PMID: 37872133.